Results 11 to 20 of about 25,303 (208)
Frontiers in Medicine, 2022 Sickle cell disease (SCD) is a heterogeneous group of inherited disorders characterized by the production of sickle hemoglobin which is less soluble than an adult or fetal hemoglobin.
Awni Alshurafa, Mohamed A. Yassin
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Sickle Hemoglobin: A Specific Radioimmunoassay [PDF]
Blood, 1974 Abstract For the quantitation of hemoglobin S, a radioimmunoassay has been developed which is specific and highly sensitive. Hemoglobin S was purified by column chromatography and injected with complete Freund’s adjuvant into goats.
P T, Rowley +3 more
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Haematologica, 2013 The aim of the study was to determine the factors associated with resting and exercise-induced hemoglobin oxygen desaturation. The well-established six-minute walk test was conducted in 107 sickle cell children (50 with sickle hemoglobin C disease and 57
Xavier Waltz +12 more
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Asian Journal of Medical Sciences, 2022 Background: Sickle cell disease (SCD), also known as sickle cell anemia, is a dangerous disease in which the body produces an abnormal form of hemoglobin, the protein in red blood cells that transport oxygen throughout the body. The body produces sickle-
Salma Mahaboob R +5 more
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Perspective: A novel prognostic for sickle cell disease
Saudi Journal of Medicine and Medical Sciences, 2018 Sickle hemoglobin (α2βS2) polymerization drives disease pathophysiology in sickle cell anemia. Fetal hemoglobin (α2γ2) restricts disease severity by inhibiting the polymerization of sickle hemoglobin in a concentration-dependent manner. Clinical decision-
Brian M Mozeleski +3 more
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The Growth of Sickle Hemoglobin Polymers [PDF]
Biophysical Journal, 2011 The measurement of polymer growth is an essential element in characterization of assembly. We have developed a precise method of measuring the growth of sickle hemoglobin polymers by observing the time required for polymers to traverse a photolytically produced channel between a region in which polymers are created and a detection region.
Aprelev, Alexey +2 more
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Targeting sickle cell disease root-cause pathophysiology with small molecules
Haematologica, 2019 The complex, frequently devastating, multi-organ pathophysiology of sickle cell disease has a single root cause: polymerization of deoxygenated sickle hemoglobin.
Yogen Saunthararajah
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The Scientific World Journal, 2008 The root cause of sickle cell disease is a single β-globin gene mutation coding for the sickle β-hemoglobin chain. Sickle hemoglobin tetramers polymerize when deoxygenated, damaging the sickle erythrocyte.
Martin H. Steinberg
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Advances in Hematology, 2021 Sickle cell disease is a hereditary disease that predominantly affects black people. It is very widespread in sub-Saharan Africa, particularly at the Lehmann “sickle belt” level, where the prevalence of the hemoglobin S involves at least 10% of the ...
Jeannette Bassimbié Kakou Danho +4 more
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Prevalence of Haemoglobine s in Araraquara-SP Population.
Revista Brasileira Multidisciplinar - ReBraM /Brazilian Multidisciplinay Journal, 2015 The Sickle Cell Anemia is a genetic hemoglobionopathy, characterized by an alteration in the hemoglobin molecule struture (HbA1), called hemoglobin S (HbS), which causes a distortion in the erythocytes structure, changing from spherical shape to sickle ...
Bruno Rocha de Jesus +4 more
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