Results 11 to 20 of about 204,284 (265)

An “acquired” hemoglobin J variant in a sickle cell disease patient

Therapeutics and Clinical Risk Management, 2008
Nawwar Swedan1, Kathleen Nicol2, Phylis Moder2, Samir Kahwash21Fellow in Transfusion Medicine, Ohio State University, Columbus, Ohio; 2Department of Laboratory Medicine, Nationwide Children’s Hospital, Columbus, OhioAbstract: We report the case
Nawwar Swedan, Kathleen Nicol, Phylis Moder, Samir Kahwash   +3 more
doaj   +1 more source

Feasibility and utility of a sickle cell disease registry for research and patient management [PDF]

, 2009
This thesis was submitted for the degree of Doctor of Philosophy and awarded by Brunel University.This thesis aimed to evaluate the feasibility and utility of a sickle cell disease registry for clinical patient management and research.
Gilmore, Annette
core   +7 more sources

Knowledge and Attitudes towards Sickle Cell Disease Screening: A Study of Members of the UK Sickle Cell Society [PDF]

, 2006
Over the past fifty years there has been an increase in the number of people in the UK who have a Sickle Cell Disorder (SCD) or are carriers. This increase has led to an expansion in research in this area; however one particular area that has not been ...
Millan, Jenny, van Teijlingen, Edwin, Eboh, Win   +2 more
core   +9 more sources

Sickle Hemoglobin: A Specific Radioimmunoassay [PDF]

Blood, 1974
Abstract For the quantitation of hemoglobin S, a radioimmunoassay has been developed which is specific and highly sensitive. Hemoglobin S was purified by column chromatography and injected with complete Freund’s adjuvant into goats.
P T, Rowley, R A, Doherty, C, Rosecrans, E, Cernichiari   +3 more
openaire   +2 more sources

Hematologic and hemorheological determinants of resting and exercise-induced hemoglobin oxygen desaturation in children with sickle cell disease

Haematologica, 2013
The aim of the study was to determine the factors associated with resting and exercise-induced hemoglobin oxygen desaturation. The well-established six-minute walk test was conducted in 107 sickle cell children (50 with sickle hemoglobin C disease and 57
Xavier Waltz, Marc Romana, Marie-Laure Lalanne-Mistrih, Roberto F. Machado, Yann Lamarre, Vanessa Tarer, Marie-Dominique Hardy-Dessources, Benoît Tressières, Lydia Divialle-Doumdo, Marie Petras, Frederic Maillard, Maryse Etienne-Julan, Philippe Connes   +12 more
doaj   +1 more source

Study on HemoTypeSC™ test for the rapid screening of sickle cell disease patients in Government Medical College and Hospital, Ambikapur

Asian Journal of Medical Sciences, 2022
Background: Sickle cell disease (SCD), also known as sickle cell anemia, is a dangerous disease in which the body produces an abnormal form of hemoglobin, the protein in red blood cells that transport oxygen throughout the body. The body produces sickle-
Salma Mahaboob R , Obulesu G , Rajesh Kumar Srivastava , Murthy R , Parmanand Agarwal , Arya R C   +5 more
doaj   +1 more source

Nutritional status, hospitalization and mortality among patients with sickle cell anemia in Tanzania. [PDF]

, 2011
BACKGROUND: Reduced growth is common in children with sickle cell anemia, but few data exist on associations with long-term clinical course. Our objective was to determine the prevalence of malnutrition at enrollment into a hospital-based cohort and ...
Soka, Deogratius, Prentice, AM, Komba, Albert N, Prentice, Andrew M, C. R. Newton, A. M. Prentice, Komba, AN, Williams, TN, Fulford, AJ, Makani, J, Newton, Charles R, S. E. Cox, D. Soka, Newton, CR, A. N. Komba, Soka, D, Marsh, K, Cox, SE, Fulford, Anthony J, K. Marsh, Williams, Thomas N, J. Makani, Cox, Sharon E, Williams, Thomas, Makani, Julie, Marsh, Kevin, T. N. Williams, A. J. Fulford   +27 more
core   +1 more source

Perspective: A novel prognostic for sickle cell disease

Saudi Journal of Medicine and Medical Sciences, 2018
Sickle hemoglobin (α2βS2) polymerization drives disease pathophysiology in sickle cell anemia. Fetal hemoglobin (α2γ2) restricts disease severity by inhibiting the polymerization of sickle hemoglobin in a concentration-dependent manner. Clinical decision-
Brian M Mozeleski, Abdullah Al-Rubaish, Amein Al-Ali, Jose Romero   +3 more
doaj   +1 more source

Genetic association of fetal-hemoglobin levels in individuals with sickle cell disease in Tanzania maps to conserved regulatory elements within the MYB core enhancer. [PDF]

, 2015
BACKGROUND: Common genetic variants residing near upstream regulatory elements for MYB, the gene encoding transcription factor cMYB, promote the persistence of fetal hemoglobin (HbF) into adulthood. While they have no consequences in healthy individuals,
Soka, Deogratius, Harvest Mariki, Menzel, Stephan, Jeffrey C Barrett, Mariki, Harvest, Helen Rooks, Bruno Mmbando, Menzel, Stephan; id_orcid, Mmbando, Bruno, Tarjinder Singh, Stephan Menzel, Barrett, Jeffrey C., Sharon E Cox, Singh, Tarjinder, Mtatiro, Siana N, Barrett, Jeffrey C, Thein, Swee Lay, Deogratius Soka, Swee Lay Thein, Julie Makani, Mtatiro, Siana N., Siana N Mtatiro, Cox, Sharon E, Rooks, Helen, Mgaya, Josephine, Makani, Julie, Josephine Mgaya, Cox, Sharon E.   +27 more
core   +2 more sources

The Growth of Sickle Hemoglobin Polymers [PDF]

Biophysical Journal, 2011
The measurement of polymer growth is an essential element in characterization of assembly. We have developed a precise method of measuring the growth of sickle hemoglobin polymers by observing the time required for polymers to traverse a photolytically produced channel between a region in which polymers are created and a detection region.
Aprelev, Alexey, Liu, Zenghui, Ferrone, Frank A.   +2 more
openaire   +2 more sources