Results 131 to 140 of about 46,454 (250)

Michael Acceptor Compounds as Hemoglobin Oxygen Affinity Modulators for Reversing Sickling of Red Blood Cells

Pharmaceuticals
Background/Objectives: Sickle cell disease (SCD) is caused by a β-globin gene mutation (βGlu6Val) that produces sickle hemoglobin (HbS). When deoxygenated, HbS polymerizes, leading to red blood cell (RBC) sickling; therefore, hemoglobin is a central ...
Khadijah A. Mohammad, Asala H. Naghi, Mohini S. Ghatge, Benita Balogun, Mariana Macias, Salma Roland, Albert Opare, Osheiza Abdulmalik, Martin K. Safo, Abdelsattar M. Omar, Moustafa E. El-Araby   +10 more
doaj   +1 more source

Inherited hemolytic disorders with high occurrence of b-thalassemia in Sindhi community of Jabalpur town in Madhya Pradesh, India [PDF]

, 2010
Hereditary hemolytic disorders such as hemoglobin disorders, β-thalassemia syndrome, G6PD deficiency, and ABO and Rhesus blood groups are the most common public health problems in India.
Balgir, RS
core   +1 more source

A rare case of pediatric autoimmune pancreatitis and autoimmune hepatitis in a patient with sickle cell disease

JPGN Reports, Volume 7, Issue 1, Page 142-146, February 2026.
Abstract Concurrent pediatric autoimmune pancreatitis (AIP) and autoimmune hepatitis (AIH) are rarely reported, and no established pediatric‐specific guidelines are available to guide the diagnosis and management of these conditions in children. While AIP and AIH share an underlying autoimmune mechanism of injury, marked by chronic inflammatory changes
Sasha‐Jane Abi‐Aad, Michelle Edward, David Germain, Rene Gomez‐Esquivel, Racha Khalaf   +4 more
wiley   +1 more source

Radiologic Evaluation of Paranasal Sinuses in Sickle Cell Anemia and Thalassemia: Case–Control Study

Laryngoscope Investigative Otolaryngology
Background Sickle cell disease and thalassemia are inherited hematological disorders that are common worldwide. These patients suffer from chronic hemolytic anemia, which can result in bone marrow dysfunction and, in rare cases, extramedullary ...
Maha A. Alharbi, Ayat AlDarwish, Reem M. Alamier, Nawal E. Omer, Mahmoud A. Alabbad, Abdulmohsin M. Aljassem, Qasem M. ALalwan, Danah H. Althomaly, Hussain Abdullali Albaharna   +8 more
doaj   +1 more source

Tocilizumab provides a potential therapeutic option for the management of hyperhaemolysis syndrome in sickle cell disease: A case series and brief narrative overview of the literature

Transfusion Medicine, Volume 36, Issue 1, Page 66-71, February 2026.
Abstract Background and Objectives Hyperhaemolysis syndrome is a life‐threatening complication of transfusion, potentially triggered by macrophage activation, with limited treatment options. Tocilizumab, an anti‐IL6 monoclonal antibody, has mechanistic rationale for use and has been shown to be effective in a small number of cases.
S. Wolf, B. Singh, A. Zaidi, P. Greaves, F. Oyesanya, S. Bennett, B. Kaya, F. Barroso, P. Telfer   +8 more
wiley   +1 more source

Drugs for preventing red blood cell dehydration in people with sickle cell disease. [PDF]

, 2018
BACKGROUND: Sickle cell disease is an inherited disorder of hemoglobin, resulting in abnormal red blood cells. These are rigid and may block blood vessels leading to acute painful crises and other complications.
Ballas, Samir K., Nagalla, Srikanth
core   +1 more source

Detecting sickle hemoglobin. [PDF]

BMJ, 1972
openaire   +2 more sources

Mechanistic Consequences of Piezo1 Gain‐of‐Function Variants for Decreased Red Cell Survival in Hereditary Xerocytosis

American Journal of Hematology, Volume 101, Issue 3, Page 619-622, March 2026.
Asya Makhro, Rick Huisjes, Elena Seiler, Min Qiao, Marije Bartels, Inga Hegemann, Patrick Eppenberger, Nicole Bender, Isabel Dorn, Anna Bogdanova, Richard van Wijk, Lars Kaestner   +11 more
wiley   +1 more source

An audit of platelet transfusions at a tertiary care center: New opportunities for patient blood management with the 2025 AABB/ICTMG platelet guidelines

Transfusion, Volume 66, Issue 2, Page 352-361, February 2026.
Abstract Background Platelet transfusions are an important tool to prevent and stop bleeding. Thresholds for pretransfusion platelet counts have been studied in various patient populations, yielding evidence‐based guidelines. The Association for the Advancement of Blood and Biotherapies (AABB) collaborated with the International Collaboration for ...
Rylee Yakymi, Claudia S. Cohn
wiley   +1 more source

Cost‐effectiveness of a hypothetical assay to evaluate stored blood quality prior to transfusion

Vox Sanguinis, Volume 121, Issue 2, Page 142-151, February 2026.
Abstract Background and Objectives Unsuccessful red blood cell (RBC) transfusion, necessitating unscheduled repeat transfusion, is common and costly. Several technologies have been developed to assess stored blood quality, but the potential cost‐effectiveness of pretransfusion testing versus no testing to prevent unscheduled re‐transfusion is unknown ...
Melissa C. Caughey, Tara Templin, Nareg H. Roubinian, Matthew S. Karafin   +3 more
wiley   +1 more source