Results 61 to 70 of about 98,754 (272)
Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions
FEBS Letters, EarlyView.Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf +6 more
wiley +1 more source
Structural and functional heterogeneity in phloem loading and transport
Frontiers in Plant Science, 2013 The phloem is often regarded as a relatively straightforward transport system composed of loading (collection), long-distance (transport) and unloading zones.
Thomas L. Slewinski +2 more
doaj +1 more source
Sieve-element differentiation and phloem sap contamination
Current Opinion in Plant Biology, 2018 Sieve elements (SEs) degrade selected organelles and cytoplasmic structures when they differentiate. According to classical investigations, only smooth ER, mitochondria, sieve element plastids, and, in most cases, P-proteins remain in mature SEs. More recent proteomics and immuno-histochemical studies, however, suggested that additional components ...
Michael, Knoblauch +4 more
openaire +3 more sources
Streaming Robust Submodular Maximization: A Partitioned Thresholding Approach [PDF]
, 2017 We study the classical problem of maximizing a monotone submodular function subject to a cardinality constraint k, with two additional twists: (i) elements arrive in a streaming fashion, and (ii) m items from the algorithm's memory are removed after the ...
Bogunovic, Ilija +4 more
core +1 more source
FEBS Letters, EarlyView.Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes +4 more
wiley +1 more source
Resin-embedded Thin-section Immunohistochemistry Coupled with Triple Cellular Counterstaining
Bio-Protocol, 2017 This protocol was developed to study protein localisation within the vascular bundles of developing tomato fruit however, it can be applied to any resin embedded plant tissue.
William Palmer +2 more
doaj +1 more source
SEORious business: structural proteins in sieve tubes and their involvement in sieve element occlusion [PDF]
Journal of Experimental Botany, 2014 The phloem provides a network of sieve tubes for long-distance translocation of photosynthates. For over a century, structural proteins in sieve tubes have presented a conundrum since they presumably increase the hydraulic resistance of the tubes while no potential function other than sieve tube or wound sealing in the case of injury has been suggested.
Knoblauch, Michael +3 more
openaire +3 more sources
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source
A Note on the Sparing Number of the Sieve Graphs of Certain Graphs [PDF]
, 2015 Let $\mathbb{N}_0$ denote the set of all non-negative integers and $\mathcal{P}(\mathbb{N}_0)$ be its power set. An integer additive set-indexer (IASI) of a given graph $G$ is an injective function $f:V(G)\to \mathcal{P}(\mathbb{N}_0)$ such that the ...
Germina, Augustine, Sudev, Naduvath
core +2 more sources