Results 101 to 110 of about 5,729,125 (133)

The Src‐Family Kinases Hck, Fgr and Lyn Drive Immune Complex‐Mediated Glomerulonephritis Through the Syk Tyrosine Kinase

The FASEB Journal, Volume 40, Issue 16, 31 August 2026.
The study aimed to test the role of three Src‐family kinases, Hck, Fgr, and Lyn in immune complex glomerulonephritis. Hck, Fgr, and Lyn were overexpressed in human lupus nephritis and mouse nephrotoxic nephritis. Combined genetic deficiency of the three kinases practically completely protected mice from nephrotoxic nephritis.
Lukács S. Lesinszki, Dorottya Deli, Lili K. Boldizsár, Áron Pánczél, Attila Fintha, Michael G. Robson, Attila Mócsai   +6 more
wiley   +1 more source

Expression and clinical significance of Siglec-15 in elderly patients with laryngeal squamous cell carcinoma

Zhongguo linchuang yanjiu
Objective To investigate the expression pattern of sialic acid-binding immunoglobulin-like lectin 15 (Siglec- 15) in laryngeal squamous cell carcinoma (LSCC) and its correlation with clinical characteristics.
DU Qilong, YANG Junrong, XU Li, JIANG Lihua, YE Wei, MAO Yuan, HUANG Wen   +6 more
doaj   +1 more source

Chemical and Enzymatic Synthesis of DisialylGb5 and Other Sialosides for Glycan Array Assembly and Evaluation of Siglec-Mediated Immune Checkpoint Inhibition

Molecules
Aberrant glycosylation, especially sialylation, on cell surface is often associated with cancer progression and immunosuppression. Over-sialylation of stage-specific embryonic antigen-4 (SSEA-4) to generate disialylGb5 (DSGb5) was reported to trigger ...
Kuo-Shiang Liao, Yixuan Zhou, Cinya Chung, Chih-Chuan Kung, Chien-Tai Ren, Chung-Yi Wu, Yi-Wei Lou, Po-Kai Chuang, Balázs Imre, Yves S. Y. Hsieh, Chi-Huey Wong   +10 more
doaj   +1 more source

Sulfonylurea Bioisosteres of Sulfonic Acid in JFD 00458‐Based ST6GAL1 Inhibitors Enhance Membrane Permeability

ChemMedChem, Volume 21, Issue 16, 27 August 2026.
ST6GAL1 sialylates glycoconjugates in the Golgi, modulating immune recognition and enabling tumor immune evasion. To effectively reach ST6GAL1, inhibitors should demonstrate good membrane permeability. Based on nonpermeable hit JFD 00458, we developed sulfonylurea analogs achieving increased membrane permeability and potency.
Natan Koraj, Sushmaa Dangudubiyyam, Adelyn M. Betances‐Mora, Ema Faganeli, Anne Harduin‐Lepers, Jesús Angulo, Tan Khanh Nguyen, María Bort‐Griñó, Ramon Hurtado‐Guerrero, Marko Anderluh   +9 more
wiley   +1 more source

Siglec-1 (cd169) expresszió vizsgálata monocyta alosztályokon gyulladásos myopathiákban

Absztrakt Háttér: Az idiopathias inflammatorikus myopathiák (IIM) szisztémás autoimmun betegségek, különböző klinikai megjelenési formákkal és patomechanizmusokkal. Ezen betegségekben az interferon útvonal az egyik fontos terápiás célpontok egyike.
Kun, Zsuzsanna Bella
core  

Expression of SIGLEC15 correlates with tumor immune infiltration, molecular subtypes, and breast cancer progression.

PLoS ONE
Breast cancer (BRCA) is among the most prevalent cancers and is responsible for numerous patient fatalities. Immunotherapy has emerged as a promising approach to cancer treatment.
Huan Lai, Yiyang Liu, Yan Gong, Chuanyu Zong, Wei Zeng, Honglei Chen   +5 more
doaj   +1 more source

Siglec 15 as a biomarker or a druggable molecule for non-small cell lung cancer. [PDF]

J Cancer Res Clin Oncol, 2023
Moreira RS, da Silva MM, de Melo Vasconcelos CF, da Silva TD, Cordeiro GG, Mattos-Jr LAR, da Rocha Pitta MG, de Melo Rêgo MJB, Pereira MC.   +8 more
europepmc   +1 more source

Siglec-15 is a glyco-immune checkpoint in prostate cancer regulating immune evasion and metastasis

Prostate cancer is a leading cause of cancer-related mortality in men, and effective treatment options are limited for advanced and metastatic disease. The sialoglycan immune checkpoint Siglec-15 has emerged as a key mediator of tumour-associated immune ...
David B Sykes, Nicoll Matthews, Liancheng Lu, Richard Beatson, Matthew Fisher, Ziqian Peng, Ella P Dennis, Jennifer Munkley, Margarita Orozco-Moreno, Dallas B Flies, Feier Zeng, Libby Blencoe, Michelle A Lawson, Kirsty Hodgson, Shenglin Mei, Ning Wang   +15 more
core   +1 more source

Expression feature and prognostic function of a novel immune checkpoint Siglec-15 in human colorectal cancer [PDF]

Background. Sialic acid-bound immuno-globulin lectin 15 (Siglec-15) plays an important role in the development of cancer. However, the association between Siglec-15 expression and clinicopathological characteristics of colorectal cancer (CRC) has not ...
Xu, Li, Huang, Wen, Yang, Junrong, Zhou, Linyun, Zhu, Yidan, Ding, Run, Liang, Guodong, Fan, Yang   +7 more
core  

Tumor-associated macrophages: untapped molecular targets to improve T cell-based immunotherapy

Molecular Cancer
T cell responses are generally curtailed by suppressive mechanisms within the tumor microenvironment (TME) that prevent T cell infiltration and function.
Rui M. L. Coelho, Reno Debets, Dora Hammerl   +2 more
doaj   +1 more source