Results 81 to 90 of about 5,729,125 (133)

Genetic risk variants implicate impaired maintenance and repair of periodontal tissues as causal for periodontitis—A synthesis of recent findings

Periodontology 2000, EarlyView.
AbstractPeriodontitis is a complex inflammatory disease in which the host genome, in conjunction with extrinsic factors, determines susceptibility and progression. Genetic predisposition is the strongest risk factor in the first decades of life. As people age, chronic exposure to the periodontal microbiome puts a strain on the proper maintenance of ...
Arne S. Schaefer, Luigi Nibali, Noha Zoheir, Niki M. Moutsopoulos, Bruno G. Loos   +4 more
wiley   +1 more source

Protein O‐Glycosylation Shapes Lymphatic Endothelia and Lymph Node Macrophage Populations

The FASEB Journal, Volume 40, Issue 18, 30 September 2026.
To study the functional roles of O‐glycans on lymphatic endothelia, we deleted Cosmc, the chaperone required for core‐1 O‐glycan synthesis. Loss of core‐1 O‐glycans entailed major changes in glycoprotein composition of lymphatic endothelial cells (LEC), including reduced podoplanin (Pdpn), CD44, and Lyve‐1, and increased ICAM‐1; reduced CD44 was caused
Jasmin Frey, Annkathrin Ratter, Finn Brigger, Louie Cielen, Pascal Kunz, Ea Tulin, Kinga Mikos, Lothar Dieterich, Marco D'Addio, Cornelia Halin, Richard D. Cummings, Vivianne I. Otto   +11 more
wiley   +1 more source

Placental Site Trophoblastic Tumor Acquires Immune Functions by Incorporating Host Maternal Genes

Advanced Science, Volume 13, Issue 50, 7 September 2026.
PSTT cells, through cell fusion with B cells, incorporate abundant non‐inherited maternal genes that are detectable by DNIMA. These hybrid cells acquire immunotherapy‐resistant genetic changes and increase the expression of B cell‐derived immune‐related molecules such as Ig, HLA, LILRB, SIGLEC10, and so on, creating an immunotolerant environment around
Kyosuke Kagami, Masanori Ono, Yasunari Mizumoto, Tatsuhito Kanda, Takashi Iizuka, Takiko Daikoku, Shin‐ichi Horike, Akira Hattori, Akihito Horie, Sachiko Minamiguchi, Tomoko Fujiwara, Kazuyoshi Hosomichi, Atsushi Tajima, Hirokazu Usui, Kaoru Abiko, Hiroshi Fujiwara   +15 more
wiley   +1 more source

Role of macrophage sialoadhesin in host defense against the sialylated pathogen group B Streptococcus [PDF]

, 2014
Several bacterial pathogens decorate their surfaces with sialic acid (Sia) residues within cell wall components or capsular exopolysaccharides. Sialic acid expression can promote bacterial virulence by blocking complement activation or by engagement of ...
Joshua Olson, Louie, Aaron, Crocker, Paul R., Victor Nizet, Aaron Louie, Ajit Varki, Paul R. Crocker, Varki, Ajit, Nizet, Victor, Yung-Chi Chang, Chang, Yung-Chi, Olson, Joshua   +11 more
core   +1 more source

Anti-Siglec-15 antibody suppresses bone resorption by inhibiting osteoclast multinucleation without attenuating bone formation [PDF]

Tsukazaki H., Kikuta J., Ao T., et al. Anti-Siglec-15 antibody suppresses bone resorption by inhibiting osteoclast multinucleation without attenuating bone formation.
Kikuta, Junichi, Tsuda, Eisuke, Minoshima, Masafumi, Ao, Tomoka, Fukuda, Chie, Ishii, Masaru, Kikuchi, Kazuya, Tsukazaki, Hiroyuki, Kaito, Takashi, Morimoto, Akito   +9 more
core   +2 more sources

Engineering Antibodies into Targeted Chimeras: From Recognition Modules to Programmable Degraders

Advanced Science, Volume 13, Issue 50, 7 September 2026.
Antibody can be engineered into diverse lysosome‐targeting chimeras that convert target recognition into active degradation. By coupling antibody binding with recruited receptors, encoded domains, conjugated ligands, or nanoparticle scaffolds, these antibody‐associated targeted chimeras (AbTACs) platforms direct extracellular and membrane proteins ...
Kaige Chen, Quanyin Hu
wiley   +1 more source

A Multifaceted Interplay Among Hemophagocytosis, Interleukin‐18, and Type I Interferon Distinguishes Still Disease From Other Autoinflammatory Diseases

Arthritis &Rheumatology, Volume 78, Issue 9, Page 1961-1974, September 2026.
Objective The unknown pathophysiology and the lack of specific features for systemic juvenile idiopathic arthritis and adult‐onset Still disease (collectively known as Still disease; SD) delay diagnosis and appropriate treatment. The goal of this study was to identify features and mechanisms that distinguish SD from other systemic autoinflammatory ...
Yvonne M. Mueller, Charlotte Girard, Harmen J. G. van de Werken, Stefan J. Erkeland, Dwin G. B. Grashof, Laurie Vaillant, Renske J. H. den Dekker, Iris van Zuijen, Sharon Veenbergen, Fanny Coffin, Eric Bindels, Yvan Jamilloux, Katerina Laskari, Vassili Soumelis, Bruno Fautrel, Cem Gabay, Peter D. Katsikis   +16 more
wiley   +1 more source

Microglia and neuroinflammation: An in‐depth analysis from functional diversity to disease mechanisms

Clinical and Translational Medicine, Volume 16, Issue 9, September 2026.
1. Microglial functions arise from dynamic, context‐dependent programs rather than fixed M1/M2 phenotypes. 2. Inflammatory, interferon‐responsive, phagocytic/lipid‐metabolic and repair‐associated programs coexist across disease stages and brain regions. 3.
Jie Chen, Wangzheqi Zhang, Lizhou Song, Yan Liao, Haoling Zhang, Yiyang Xia, Derong Cui   +6 more
wiley   +1 more source

SHIP1 Restrains Hypoxia/Reoxygenation‐Induced Cytokine Secretion in Mouse Bone Marrow–Derived Mast Cells

European Journal of Immunology, Volume 56, Issue 9, September 2026.
(A) BMMCs are substantially more resistant to oxygen deprivation than neurons, microglia, oligodendrocytes, astrocytes, and fibroblasts. (B) Role of SHIP‐1 in primary mouse bone marrow mast cells’ hypoxia response. Under hypoxia, SHIP‐1 induces cytokine release. SHIP1 restrains hypoxia/reoxygenation‐induced cytokine secretion in BMMCs via the RAS/ RAF,
Lara Gubeljak, Jonas Pes, Eren Arik, Aaron T. Fehr, Mara Schietinger, Thomas Wilhelm, Sandro Capellman, Michael Huber, Pardes Habib   +8 more
wiley   +1 more source

The C‐Type Lectin Mincle Serves as a Pattern Recognition Receptor for the Lipid Envelope of Human Cytomegalovirus

European Journal of Immunology, Volume 56, Issue 9, September 2026.
Whether viral lipids can directly interact with pattern recognition receptors to modulate antiviral immune responses remains unclear. We show that Mincle‐dependent recognition of HCMV viral particles induces proinflammatory cytokine production in primary human macrophages.
Vladimir Bokun, Wengang Chai, Robert Buchanan, Elliot Murphy, Yan Liu, Beth Holder, Alexiane Decout   +6 more
wiley   +1 more source