Results 31 to 40 of about 5,729,125 (133)

Transcriptional Regulation of Siglec-15 by ETS-1 and ETS-2 in Hepatocellular Carcinoma Cells. [PDF]

Int J Mol Sci, 2023
Sialic acid-binding immunoglobulin-like lectin 15 (Siglec-15) has been identified as a crucial immune suppressor in human cancers, comparable to programmed cell death 1 ligand (PD-L1).
Sheng K, Wu Y, Lin H, Fang M, Xue C, Lin X, Lin X.   +6 more
europepmc   +2 more sources

Sialic acid-binding immunoglobulin-like lectin-15 expression on peritumoral macrophages is a favorable prognostic factor for primary central nervous system lymphoma patients

Scientific Reports, 2021
Sialic acid-binding immunoglobulin-like lectin-15 (Siglec-15) is a new immune checkpoint molecule and its role of primary central nervous system lymphoma (PCNSL) tumor microenvironment has been unclear.
Hirotaka Fudaba, Yasutomo Momii, Taisei Hirakawa, Kouhei Onishi, Daigo Asou, Wataru Matsushita, Yukari Kawasaki, Kenji Sugita, Minoru Fujiki   +8 more
doaj   +1 more source

Siglec-9 blocking antibody characterization.

, 2021
(A) Binding ELISA of anti-Siglec-9 antibody. Recombinant human Siglec-9 protein was used in ELISA to assess the antigen-specific binding of the Siglec-9 blocking antibody. His-tag protein was used as a negative control.
Han Xiao (373894), Opeyemi S. Adeniji (11682034), Ziyang Xu (1322553), Glen M. Chew (7122281), Costin Tomescu (606955), Ashley F. George (11682037), Mohamed Abdel-Mohsen (283492), Leticia Kuri-Cervantes (7382828), Chenfei Yu (1586326), Lishomwa C. Ndhlovu (7122293), David B. Weiner (9579320), Michelle Ho (6311882), Qin Liu (59805), Michael R. Betts (11682040), Nadia R. Roan (1320618), Kar Muthumani (504713), Cecilia Shikuma (22963)   +16 more
core   +1 more source

Siglec-9⁺ CD56^dim NK cells exhibit higher cytotoxicity towards HIV+ cells compared to Siglec-9^- CD56^dim NK cells.

, 2021
(A) A representative example of depletion of Siglec-9+ NK cells. (B) Siglec-9depleted NK cells exhibit lower cytotoxicity towards HIV-infected HUT78/SF2 targets compared to total NK cells. Cytotoxicity was assessed using NK degranulation, left panel (n =
Han Xiao (373894), Opeyemi S. Adeniji (11682034), Ziyang Xu (1322553), Glen M. Chew (7122281), Costin Tomescu (606955), Ashley F. George (11682037), Mohamed Abdel-Mohsen (283492), Leticia Kuri-Cervantes (7382828), Chenfei Yu (1586326), Lishomwa C. Ndhlovu (7122293), David B. Weiner (9579320), Michelle Ho (6311882), Qin Liu (59805), Michael R. Betts (11682040), Nadia R. Roan (1320618), Kar Muthumani (504713), Cecilia Shikuma (22963)   +16 more
core   +1 more source

Siglec-15: a potential regulator of osteoporosis, cancer, and infectious diseases

Journal of Biomedical Science, 2020
Siglec-15 is a member of the Siglec family of glycan-recognition proteins, primarily expressed on a subset of myeloid cells. Siglec-15 has been known to be involved in osteoclast differentiation, and is considered to be a potential therapeutic target for
Takashi Angata
doaj   +1 more source

Siglec-9⁺ CD56^dim NK cells express CD7.

, 2021
Fresh human PBMCs from an HIV-negative donor were stained for CD3, CD56, CD7, and Siglec-9. The majority of Siglec-9+ CD56dim NK cells express CD7, decreasing the chance that these cells are monocytes. FMO = Fluorescence Minus One. (EPS)
Han Xiao (373894), Opeyemi S. Adeniji (11682034), Ziyang Xu (1322553), Glen M. Chew (7122281), Costin Tomescu (606955), Ashley F. George (11682037), Mohamed Abdel-Mohsen (283492), Leticia Kuri-Cervantes (7382828), Chenfei Yu (1586326), Lishomwa C. Ndhlovu (7122293), David B. Weiner (9579320), Michelle Ho (6311882), Qin Liu (59805), Michael R. Betts (11682040), Nadia R. Roan (1320618), Kar Muthumani (504713), Cecilia Shikuma (22963)   +16 more
core   +1 more source

Research progress and prospect of Siglec in innate immune cells in tumor [PDF]

Zhongguo aizheng zazhi, 2022
Immunotherapy brings hope to those patients suffering from malignant tumor. However, common immunotherapy targets, such as cytotoxic T lymphocyte-associated antigen-4 (CTLA-4) and programmed death ligand-1 (PD-L1), have low positive expression rate in ...
Zhaoyang GUO, Jingzhou HU
doaj   +2 more sources

An antibody against Siglec-15 promotes bone formation and fracture healing by increasing TRAP+ mononuclear cells and PDGF-BB secretion

Bone Research, 2021
Osteoporosis (OP) is a common age-related disease characterized by a deterioration of bone mass and structure that predisposes patients to fragility fractures.
Gehua Zhen, Yang Dan, Ruomei Wang, Ce Dou, Qiaoyue Guo, Melissa Zarr, Linda N. Liu, Lieping Chen, Ruoxian Deng, Yusheng Li, Zengwu Shao, Xu Cao   +11 more
doaj   +1 more source

Pseudaminic acid on Campylobacter jejuni flagella modulates dendritic cell IL-10 expression via Siglec-10 receptor: a novel flagellin-host interaction. [PDF]

, 2014
INTRODUCTION: Campylobacter jejuni is a leading cause of bacterial gastroenteritis worldwide. At present the identity of host-pathogen interactions that promote successful bacterial colonisation remain ill defined.
Crocker, Paul R., Stephenson, Holly N, Escors, David, Copland, Alastair, Crocker, Paul R, Wren, Brendan W, Dorrell, Nick, Jones, Hannah, Stephenson, Holly N., Wren, Brendan W., Mills, Dominic C, Milioris, Enea, Mills, Dominic C., Bajaj-Elliott, Mona   +13 more
core   +1 more source

Siglec-E promotes β2-integrin-dependent NADPH oxidase activation to suppress neutrophil recruitment to the lung [PDF]

, 2014
Siglec-E is a sialic acid-binding Ig-like lectin expressed on murine myeloid cells. It has recently been shown to function as a negative regulator of ß2-integrin-dependent neutrophil recruitment to the lung following exposure to lipopolysaccharide (LPS).
Hegde, Vikas, Crocker, Paul R., Sarah J. McMillan, Ritu S. Sharma, Vikas Hegde, Paul R. Crocker, McMillan, Sarah J., Sharma, Ritu S., Richards, Hannah E., Hannah E. Richards   +9 more
core   +1 more source