Results 41 to 50 of about 5,729,125 (133)

Siglec-9⁺ CD56^dim cells exhibit lower cytotoxicity towards K562 cancer cells compared to Siglec-9^- CD56^dim.

, 2021
Cytotoxicity was assessed using NK degranulation and IFNγ production (E: T = 4:1). Total NK cells were gated on Siglec-9+ or Siglec-9- CD56dim NK cell subsets.
Han Xiao (373894), Opeyemi S. Adeniji (11682034), Ziyang Xu (1322553), Glen M. Chew (7122281), Costin Tomescu (606955), Ashley F. George (11682037), Mohamed Abdel-Mohsen (283492), Leticia Kuri-Cervantes (7382828), Chenfei Yu (1586326), Lishomwa C. Ndhlovu (7122293), David B. Weiner (9579320), Michelle Ho (6311882), Qin Liu (59805), Michael R. Betts (11682040), Nadia R. Roan (1320618), Kar Muthumani (504713), Cecilia Shikuma (22963)   +16 more
core   +1 more source

Siglec-7 restores β-cell function and survival and reduces inflammation in pancreatic islets from patients with diabetes.

, 2017
Chronic inflammation plays a key role in both type 1 and type 2 diabetes. Cytokine and chemokine production within the islets in a diabetic milieu results in β-cell failure and diabetes progression.
G Dharmadhikari (21879041), NG Morgan (21853058), A Varki (21879047), K Stolz (21879044), K Maedler (21879056), M Hauke (20714723), S Kelm (21879053), E de Koning (21879050)   +7 more
core   +6 more sources

Anti-Tumor Activities of Anti-Siglec-15 Chimeric Heavy-Chain Antibodies. [PDF]

Int J Mol Sci
Immune checkpoint inhibitors like programmed cell death 1 (PD-1) antibodies have revolutionized cancer treatment, but patient response rates remain limited.
Cheng K, Guo J, Li Y, Kang Q, Wang R, Luo L, Wang W, Lu J.   +7 more
europepmc   +2 more sources

Long Noncoding RNA TUG1 Inhibits Tumor Progression through Regulating Siglec-15-Related Anti-Immune Activity in Hepatocellular Carcinoma

Journal of Immunology Research, 2022
Background. Hepatocellular carcinoma (HCC) is the second leading cause of cancer-related death, and its biology remains poorly understood, especially in regards to the immunosuppression induced by immune checkpoints, such as Siglec-15.
Yanyi Ren, Jiayi Lyu, Yaoguang Guo, Yuan Yao, Lin Hu   +4 more
doaj   +1 more source

Carbohydrate‐Directed Labeling Probes for UV‐Independent Chemoproteomic Profiling of Carbohydrate–Protein Interactions

Angewandte Chemie, EarlyView.
Modular carbohydrate‐directed labeling probes (CDLPs) convert weak carbohydrate–protein interactions into durable covalent tags in live cells without the need for multivalency or UV irradiation. Ligand binding triggers proximity‐enabled, glycan‐releasing acyl transfer to install a click handle for protein tagging and chemoproteomic profiling.
Matthew C. Russolillo, Wariya Nirachonkul, Nora Ross, Rahul M. Hedau, Zachary Clark, Michaella J. Rekowski, Michael P. Washburn, Mark P. Farrell   +7 more
wiley   +2 more sources

Additional file 2 of Siglec-15-induced autophagy promotes invasion and metastasis of human osteosarcoma cells by activating the epithelial–mesenchymal transition and Beclin-1/ATG14 pathway

, 2022
Additional file 2: FigureS2. Effect of Siglec-15 expressionrecovery on migration, invasion and autophagy of osteosarcoma cells. (a) Westernblots were used to detect the expression of EMT and autophagy-related proteinsin shSiglec-15-KHOS cells recovering ...
Chuanli Zhou (439175), Peng Yan (465646), Wenfang Chen (331226), Wei Guo (86150), Bin Yue (13111285), Lingling Sun (310915), Chongmin Ren (13111282), Yan Qu (682614), Keliang Song (13111279), Yang Gao (18005), Bingxin Zheng (4831539)   +10 more
core   +1 more source

Die Rolle von Siglec-15 auf Osteoklasten und in Arthritis-Mausmodellen [PDF]

, 2022
Das Sialinsäure-bindende Immunglobulin-ähnliche Lektin 15 (Siglec-15) ist ein aktivierender Regulator der Osteoklastogenese und ist am physiologischen Knochenumbauprozess beteiligt. Diese Rolle von Siglec-15 konnte im Rahmen dieser Arbeit mit laborintern-
Korn, Marina
core   +1 more source

Image_1_Sialic Acid-Siglec-E Interactions During Pseudomonas aeruginosa Infection of Macrophages Interferes With Phagosome Maturation by Altering Intracellular Calcium Concentrations.TIF

, 2020
Pseudomonas aeruginosa (PA) is commonly associated with nosocomial and chronic infections of lungs. We have earlier demonstrated that an acidic sugar, sialic acid, is present in PA which is recognized and bound by sialic acid binding immunoglobulin type ...
Chitra Mandal (148111), Kaustuv Mukherjee (5277620), Biswajit Khatua (8504463)   +2 more
core   +1 more source

Nanomaterials for Allergy Diagnosis and Treatment: Advances, Opportunities and Translational Challenges

Advanced Science, EarlyView.
Nanomaterials offer dual applications in allergy management. For diagnosis, nanomaterials enhance analytical sensitivity and improve detection in specific IgE and functional assays such as the basophil activation test (BAT). For allergen‐specific immunotherapy, nanomaterials enable allergen masking and controlled release, and effectively modulate the ...
Madiha Habib, Shan Jiang, Joyce ZX Lee, CW Lim, HL Yeung, Nicki YH Leung, Patrick SC Leung, Ting F Leung, Christine YY Wai   +8 more
wiley   +1 more source

Siglecs as Therapeutic Targets in Cancer

Biology, 2021
Hypersialylation is a common post-translational modification of protein and lipids found on cancer cell surfaces, which participate in cell-cell interactions and in the regulation of immune responses. Sialic acids are a family of nine-carbon α-keto acids
Jackwee Lim, Duygu Sari-Ak, Tanaya Bagga
doaj   +1 more source