Results 21 to 30 of about 11,185,234 (160)

Anti-Tumor Activities of Anti-Siglec-15 Chimeric Heavy-Chain Antibodies. [PDF]

Int J Mol Sci
Immune checkpoint inhibitors like programmed cell death 1 (PD-1) antibodies have revolutionized cancer treatment, but patient response rates remain limited.
Cheng K, Guo J, Li Y, Kang Q, Wang R, Luo L, Wang W, Lu J.   +7 more
europepmc   +3 more sources

Prognostic significance of tumoral Siglec-15 expression in solid tumors: a systematic review and meta-analysis [PDF]

Frontiers in Immunology
BackgroundSiglec-15 has emerged as a novel immune checkpoint molecule and a potential therapeutic target in solid tumors. Previous studies reported inconsistent prognostic significance of tumoral Siglec-15 expression across cancer types.
Ningning Zhang, Yuan He, Zemin Qin, Junyan Yu, Wei Guo   +4 more
doaj   +3 more sources

Anti‐Siglec‐15 Antibody Prevents Marked Bone Loss after Acute Spinal Cord Injury‐Induced Immobilization in Rats [PDF]

JBMR Plus, 2023
Rapid and extensive sublesional bone loss after spinal cord injury (SCI) is a difficult medical problem that has been refractory to available interventions except the antiresorptive agent denosumab (DMAB). While DMAB has shown some efficacy in inhibiting
Yuanzhen Peng, Solomon Langermann, Priyanka Kothari, Linda Liu, Wei Zhao, Yizhong Hu, Zihao Chen, Mariana Moraes de Lima Perini, Jiliang Li, Jay Cao, X. Edward Guo, Lieping Chen, William A. Bauman, Weiping Qin   +13 more
doaj   +3 more sources

Transcriptional Regulation of Siglec-15 by ETS-1 and ETS-2 in Hepatocellular Carcinoma Cells. [PDF]

Int J Mol Sci, 2023
Sialic acid-binding immunoglobulin-like lectin 15 (Siglec-15) has been identified as a crucial immune suppressor in human cancers, comparable to programmed cell death 1 ligand (PD-L1).
Sheng K, Wu Y, Lin H, Fang M, Xue C, Lin X, Lin X.   +6 more
europepmc   +3 more sources

Siglec-15 is a putative receptor for porcine epidemic diarrhea virus infection. [PDF]

Cell Mol Life Sci
Porcine epidemic diarrhea virus (PEDV) has caused significant losses in the pork industry, but the mechanism of PEDV infection is still unclear.
Feng Z, Fu Y, Yang S, Zhao H, Lin M, Liu C, Huang W, He X, Chen Y, Chen J, Shen Y, Li Z, Chen Q.   +12 more
europepmc   +2 more sources

Bispecific Siglec-15/T cell antibody (STAB) activates T cells and suppresses pancreatic ductal adenocarcinoma and non-small cell lung tumors in vivo. [PDF]

Theranostics
Rationale: Siglec-15 (S15) is a membrane-associated antigen overexpressed across various cancer types, and also induces immunosuppression. We believe this makes S15 a promising target for cellular immunotherapy of solid tumors characterized by an ...
Shen L, Schaefer A, Huckaby J, Wolf W, Lai SK.   +4 more
europepmc   +2 more sources

AhR-Siglec-15 axis regulates lysosomal Ca2+ release for sonic hedgehog medulloblastoma growth via TRPML1. [PDF]

Protein Cell
Sonic hedgehog subgroup medulloblastoma (SHH-MB), an aggressive pediatric brain tumor that originates from granule neuron precursors, faces the challenge of poor treatment owing to its unclear molecular mechanisms.
Wang Z, Li S, Sun X, Wang D, Zhou Y, Zhou L, Chen J, Zhou N, Zhu Q, Liu J, Zhang G, Tong WM, Lv J, Huang B.   +13 more
europepmc   +2 more sources

Significance of Siglec‐15 expression in colorectal cancer: association with advanced disease stage and fewer tumor‐infiltrating lymphocytes [PDF]

The Journal of Pathology: Clinical Research, 2023
Siglec‐15, a novel immune suppressor, is upregulated in many human cancers. The aim of this study was to explore the expression of Siglec‐15 in colorectal cancer (CRC), and investigate whether Siglec‐15 could be a potential target for cancer ...
Zhao Lu, Pu Cheng, Fei Huang, Jiyun Li, Bingzhi Wang, Shuangmei Zou, Zhaoxu Zheng, Chunwei Peng   +7 more
doaj   +2 more sources

Siglec-15 on macrophages suppress the immune microenvironment in patients with PD-L1 negative non-metastasis lung adenocarcinoma. [PDF]

Cancer Gene Ther, 2023
Sialic acid-binding immunoglobulin-like lectin 15 (Siglec-15) is an immune checkpoint molecule with sequence homology to programmed cell death ligand 1 (PD-L1), which is mainly expressed on macrophages and tumor cells.
Huang Z, Guo Y, Li B, Shen M, Yi Y, Li L, Zhao X, Yang L.   +7 more
europepmc   +2 more sources

Siglec-15/sialic acid axis as a central glyco-immune checkpoint in breast cancer bone metastasis. [PDF]

Proc Natl Acad Sci U S A
Significance The glycocalyx, a network of glycolipids and glycoproteins on cell surfaces, plays a pivotal role in immune modulation. Hypersialylated glycans have been identified as an immune suppressive marker, are exploited by tumors to evade immune ...
Wang Y, Xu Z, Wu KL, Yu L, Wang C, Ding H, Gao Y, Sun H, Wu YH, Xia M, Chen Y, Xiao H.   +11 more
europepmc   +2 more sources