Non-spatial and spatial heterogeneity revealed a suppressive immune feature of Siglec-15 in lung adenocarcinomas [PDF]
Journal of Translational Medicine, 2023 Background Sialic acid-binding immunoglobulin-like lectin-15 (Siglec-15) has emerged as a novel immunotherapy candidate, which deserves a comprehensive investigation in lung adenocarcinoma (LUAD). Methods Multiplex fluorescence‐based immunohistochemistry
Baihui Li +6 more
doaj +3 more sources
Siglec-15 as a New Perspective Therapy Target in Human Giant Cell Tumor of Bone [PDF]
Current Oncology, 2022 The main features of a giant cell tumor of bone (GCTB) are frequent recurrence and aggressive osteolysis, which leads to a poor prognosis in patients.
Mengke Fan +5 more
doaj +3 more sources
Dynamic change in Siglec-15 expression in peritumoral macrophages confers an immunosuppressive microenvironment and poor outcome in glioma [PDF]
Frontiers in Immunology, 2023 BackgroundSialic acid-binding immunoglobulin-like lectin-15 (Siglec-15) was reported to be a novel immune checkpoint molecule comparable to programmed cell death 1 ligand 1 (PD-L1).
Quan Chen +9 more
doaj +2 more sources
Analysis of a novel immune checkpoint, Siglec‐15, in pancreatic ductal adenocarcinoma [PDF]
The Journal of Pathology: Clinical Research, 2022 Siglec‐15, a novel immune checkpoint, is an emerging target for next‐generation cancer immunotherapy. However, the role of Siglec‐15 in pancreatic ductal adenocarcinoma (PDAC) remains poorly understood. We investigated the expression of Siglec‐15 and its
Xianlong Chen +6 more
doaj +2 more sources
Significance of Siglec‐15 expression in colorectal cancer: association with advanced disease stage and fewer tumor‐infiltrating lymphocytes [PDF]
The Journal of Pathology: Clinical Research, 2023 Siglec‐15, a novel immune suppressor, is upregulated in many human cancers. The aim of this study was to explore the expression of Siglec‐15 in colorectal cancer (CRC), and investigate whether Siglec‐15 could be a potential target for cancer ...
Zhao Lu +7 more
doaj +2 more sources
Prognostic value of Siglec-15 expression in patients with solid tumors: A meta-analysis [PDF]
Frontiers in Oncology, 2023 BackgroundSiglec-15 is expressed in a variety of cancers. However, the role of Siglec-15 in the prognosis of cancer patients remains controversial. Therefore, we conducted a meta-analysis to clarify the potential prognostic value of Siglec-15 in solid ...
Kui-Ying Jiang +5 more
doaj +2 more sources
Structural insights into Siglec-15 reveal glycosylation dependency for its interaction with T cells through integrin CD11b [PDF]
Nature Communications, 2023 Sialic acid-binding Ig-like lectin 15 (Siglec-15) is an immune modulator and emerging cancer immunotherapy target. However, limited understanding of its structure and mechanism of action restrains the development of drug candidates that unleash its full ...
Maria Pia Lenza +21 more
doaj +2 more sources
Prognostic value of PD-L1 and Siglec-15 expression in patients with nasopharyngeal carcinoma [PDF]
Scientific Reports, 2022 Sialic acid-binding immunoglobulin-like lectin 15 (Siglec-15) might be involved in the activation of important pathways related to tumor immune escape, along with programmed death-ligand 1 (PD-L1).
Ju Zhao +12 more
doaj +2 more sources
Siglec-15 Promotes Tumor Progression in Osteosarcoma via DUSP1/MAPK Pathway [PDF]
Frontiers in Oncology, 2021 Recurrence and metastasis are important features of osteosarcoma (OS) that cause its poor prognosis. Aberrant expression of Sialic acid-binding immunoglobulin-like lectin 15 (Siglec-15) has been reported in various kinds of cancers.
Meng-ke Fan +8 more
doaj +2 more sources
Siglec-15-induced autophagy promotes invasion and metastasis of human osteosarcoma cells by activating the epithelial–mesenchymal transition and Beclin-1/ATG14 pathway [PDF]
Cell & Bioscience, 2022 Background Pulmonary metastasis is the main cause of poor prognosis in osteosarcoma. Sialic acid-bound immunoglobulin lectin 15 (Siglec-15) has been demonstrated to be obviously correlated with pulmonary metastasis in osteosarcoma patients.
Bingxin Zheng +10 more
doaj +2 more sources