Results 111 to 120 of about 15,861 (227)

Hippo Pathway–YAP/TAZ Signaling: Molecular Mechanisms, Biological Function, Diseases, and Therapeutic Targets

MedComm, Volume 7, Issue 10, October 2026.
The Hippo–YAP/TAZ–TEAD pathway integrates mechanical and biochemical cues to govern organ growth, regeneration, cancer, and fibrosis. This review dissects pathway physiology, TEAD structural pharmacology and ligandable pockets, and therapeutic strategies spanning palmitoylation‐pocket inhibitors, PROTAC degraders, and gene/RNA therapies, highlighting ...
Xiaodan Qu, Zhan‐you Wang
wiley   +1 more source

Host–Microbe Mechanisms of Fusobacterium nucleatum in Colorectal Cancer

Molecular Oral Microbiology, Volume 41, Issue 5, Page 258-265, October 2026.
Fusobacterium nucleatum and colorectal cancer. ABSTRACT The oral‐derived pathobiont Fusobacterium nucleatum has increasingly been implicated in colorectal cancer (CRC) progression through its ability to modulate inflammatory, immunological, and molecular pathways. F.
Hadda Lyzandra Austríaco Leite, Fernanda Ferreira Lopes   +1 more
wiley   +1 more source

Comprehensive identification of the genes involved in the expression of Siglec-15 ligands on osteoclast precursors

Cell Reports
Summary: Siglec-15 regulates osteoclast differentiation. The cellular pathways contributing to the expression of Siglec-15 ligand on osteoclast precursors are incompletely understood.
Huei-Syuan Jiang, Suh-Yuen Liang, Yu-Chi Chou, Takashi Angata   +3 more
doaj   +1 more source

Seminal Extracellular Vesicles as Molecular Modulators of Male Reproductive Function

Reproduction in Domestic Animals, Volume 61, Issue S3, October 2026.
ABSTRACT Extracellular vesicles (sEVs) contained in seminal plasma (SP) maintain, in concert with free SP‐components (proteins, hormones, cytokines, metabolites and antioxidants) under an endocrine umbrella the functional in vivo homeostasis of ejaculated spermatozoa. The sEVs define a generic mixture of nanovesicles delivered by male epithelial cells,
Heriberto Rodriguez‐Martinez, Jordi Roca, Fernando Peña Vega, Emilio A. Martinez   +3 more
wiley   +1 more source

Identification of therapeutic targets and prognostic biomarkers in the Siglec family of genes in tumor immune microenvironment of sarcoma

Scientific Reports
Sarcomas (SARC) are a highly heterogeneous cancer type that is prone to recurrence and metastasis. Numerous studies have confirmed that Siglecs are involved in immune signaling and play a key role in regulating immune responses in inflammatory diseases ...
Lili Qi, Kuiying Jiang, Fei-fei Zhao, Ping Ren, Ling Wang   +4 more
doaj   +1 more source

Expression and Function of Siglec-8 in Human Eosinophils, Basophils, and Mast Cells

, 2009
Siglec-8, the eighth member of the sialic acid-binding, immunoglobulin [Ig]-like lectin family, was initially discovered as a cell surface protein selectively expressed on human eosinophils. It is now know to also be expressed by mast cells and basophils.
Bochner, Bruce S, von Gunten, Stephan
core   +1 more source

Natural anti-Siglec autoantibodies mediate potential immunoregulatory mechanisms: implications for the clinical use of intravenous immunoglobulins (IVIg)

, 2008
Human intravenous immunoglobulins (IVIg) contain natural autoantibodies against the inhibitory lectin-receptors Siglec-8 and Siglec-9. These two members of the Siglec family are known to mediate both inhibitory and death signals.
Simon, Hans-Uwe, Hans-Uwe Simon, Stephan von Gunten, von Gunten, Stephan   +3 more
core   +1 more source

Targeting Siglec-E facilitates tumor vaccine-induced antitumor immunity in renal carcinoma

Journal for ImmunoTherapy of Cancer
Background Siglec-E is an immune checkpoint inhibitory molecule. Expression of Siglec-E on the immune cells has been shown to promote tumor regression.
Yuchen Zhang, Junnian Zheng, Li Sun, Guangya Zhao, Yingxiang Shao, Bowen Lu, Jiage Ding, Yanyan Zheng, Renjin Chen, Dafei Chai, Jiawei Wang, Zichun Zhang, Xiaohui Xie   +12 more
doaj   +1 more source

Siglec-7 inhibits TLR3-induced pro-inflammatory cytokine production from human monocytes and macrophages

Frontiers in Immunology
Immune checkpoint receptors, including Sialic-acid-binding immunoglobulin-like lectins (Siglecs), are critical regulators of immune homeostasis. Siglecs can serve as negative regulators of Toll-like receptor (TLR) signaling, promoting the resolution of ...
Justin N. Keeney, Justin N. Keeney, Janina Schwarte, Bo Yang, Hendrik Wesseling, Bailin Zhang, Andrew J. McKnight, Subramanya Hegde, Guoxing Wang   +8 more
doaj   +1 more source

Siglec-1 (cd169) expresszió vizsgálata monocyta alosztályokon gyulladásos myopathiákban

Absztrakt Háttér: Az idiopathias inflammatorikus myopathiák (IIM) szisztémás autoimmun betegségek, különböző klinikai megjelenési formákkal és patomechanizmusokkal. Ezen betegségekben az interferon útvonal az egyik fontos terápiás célpontok egyike.
Kun, Zsuzsanna Bella
core