Results 301 to 310 of about 821,630 (331)

Focus on Molecules: the Sigma-1 Receptor

Experimental Eye Research, 2005
The Sigma-1 receptor (accession number NP 005857) has no known homology with other receptors and in fact most closely resembles a C-8,7 sterol isomerase found in fungi (Hayashi and Su, 2003). The gene encodes a protein consisting of 223 amino acids with two transmembrane spanning domains and a typical argenine-argenine (R–R) endoplasmic reticulum (ER ...
Duncan, George, Wang, Lixin
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Sigma-1 Receptor in Motoneuron Disease

2017
Amyotrophic Lateral Sclerosis (ALS ) is a neurodegenerative disease affecting spinal cord and brain motoneurons , leading to paralysis and early death. Multiple etiopathogenic mechanisms appear to contribute in the development of ALS , including glutamate excitotoxicity, oxidative stress , protein misfolding, mitochondrial defects, impaired axonal ...
Mancuso, Renzo, Navarro, Xavier
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Structural Perspectives on Sigma-1 Receptor Function

2017
The sigma-1 receptor is an enigmatic ER-resident transmembrane protein linked to a variety of human diseases. Although the receptor was first cloned 20 years ago, the molecular structure of the protein and the mechanistic basis for its interaction with drug-like small molecules have remained unclear until recently.
Assaf, Alon, Hayden, Schmidt, Sanduo, Zheng, Andrew C, Kruse   +3 more
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Structural Features Important for .sigma.1 Receptor Binding

Journal of Medicinal Chemistry, 1994
Two problems that have hampered sigma receptor research are (i) a lack of high-affinity agents and (ii) the recent identification of multiple populations of sigma receptors (i.e., sigma 1 and sigma 2 sites). Recently, several high-affinity sigma ligands have been identified, and the term superpotent sigma ligands has been coined to describe agents with
R A, Glennon, S Y, Ablordeppey, A M, Ismaiel, M B, el-Ashmawy, J B, Fischer, K B, Howie   +5 more
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Sigma-1 receptor and amyotrophic lateral sclerosis

Neurology, 2018
Sigma-1 receptor (Sig-1R, σ1R, also referred to as sigma receptor 1, SigR1) is an endoplasmic reticulum (ER) protein that is specifically located at the mitochondria-associated ER membrane (MAM), which interfaces between the ER and mitochondria. At the level of MAM, Sig-1R functions as a molecular chaperone that ensures proper calcium (Ca2+) transfer ...
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Sigma-1 Receptor and Neuronal Excitability

2017
The sigma-1 receptor (Sig-1R), via interaction with various proteins, including voltage-gated and ligand-gated ion channels (VGICs and LGICs), is involved in a plethora of neuronal functions. This capability to regulate a variety of ion channel targets endows the Sig-1R with a powerful capability to fine tune neuronal excitability, and thereby the ...
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Sigma-1 Receptors Modulate NMDA Receptor Function

2013
The sigma-1 receptor (σ-1R) is an endoplasmic reticulum (ER) protein that modulates a number of ion channels. It is hypothesized that σ-1Rs activated with agonist translocate to the plasma membrane. The σ-1R potentiates N-methyl-D-aspartate Receptors (NMDARs), important constituents of synaptic plasticity.
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The Sigma-1 Receptor—Orphan No More

Science Signaling, 2009
An endogenous compound is a ligand for a ubiquitously expressed receptor that binds many synthetic drugs and has been implicated in psychiatric disease.
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Targeting Sigma 1 receptor in Alzheimer's disease

2023
The broad, long-term objective of this grant application is to understand the mechanisms involved in neuroprotective action of sigma 1 receptor (S1R) agonists Alzheimer’s disease (AD).   Recent clinical and preclinical data suggest that activation of S1R may promote neuronal resilience and result in synaptoprotective and neuroprotective effects within ...
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Sigma-1 (σ1) Receptor in Memory and Neurodegenerative Diseases

2017
The sigma-1 (σ1) receptor has been associated with regulation of intracellular Ca2+ homeostasis, several cellular signaling pathways, and inter-organelle communication, in part through its chaperone activity. In vivo, agonists of the σ1 receptor enhance brain plasticity, with particularly well-described impact on learning and memory. Under pathological
Maurice, Tangui, Goguadze, Nino
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