Results 31 to 40 of about 821,630 (331)
International Journal of Cardiology: Heart & Vasculature, 2020 Sigma-1 receptors are ligand-regulated chaperone proteins, involved in several cellular mechanisms. The aim of this systematic review was to examine the effects that the sigma-1 receptor has on the cardiovascular system.
Rebecca Lewis +4 more
doaj +1 more source
Biochemical Pharmacology of the Sigma-1 Receptor [PDF]
Molecular Pharmacology, 2016 The sigma-1 receptor (S1R) is a 223 amino acid two transmembrane (TM) pass protein. It is a non-ATP-binding nonglycosylated ligand-regulated molecular chaperone of unknown three-dimensional structure. The S1R is resident to eukaryotic mitochondrial-associated endoplasmic reticulum and plasma membranes with broad functions that regulate cellular calcium
Uyen B, Chu, Arnold E, Ruoho
openaire +2 more sources
Synthesis, radiolabelling, and evaluation of [11C]PB212 as a radioligand for imaging sigma-1 receptors using PET. [PDF]
Am J Nucl Med Mol Imaging, 2018 Spinelli F +8 more
europepmc +2 more sources
Allosteric Modulation of Sigma-1 Receptors Elicits Rapid Antidepressant Activity. [PDF]
CNS Neurosci Ther, 2016 Wang Y +5 more
europepmc +2 more sources
The endogenic neurosteroid system and its role in the pathogenesis and therapy of mental disorders
Research Results in Pharmacology, 2023 Introduction: Although neurosteroids have been relatively recently discovered, their significant role in the neurochemical processes and pathogenesis of a number of psychiatric and neurological disorders is now quite clear.
Sakeena P. Bairamova +7 more
doaj +1 more source
TMEM97 and PGRMC1 do not mediate sigma-2 ligand-induced cell death [PDF]
, 2019 Sigma-2 receptors have been implicated in both tumor proliferation and neurodegenerative diseases. Recently the sigma-2 receptor was identified as transmembrane protein 97 (TMEM97).
Hawkins, William G. +9 more
core +3 more sources
SIGMAR1/Sigma-1 receptor ablation impairs autophagosome clearance [PDF]
Autophagy, 2019 Autophagosome-lysosome fusion is a common critical step in various forms of macroautophagy/autophagy including mitophagy, the selective degradation of mitochondria. Regulations of this fusion process remain poorly defined. Here we have determined the role of SIGMAR1, a unique endoplasmic reticulum membrane protein.
Huan Yang +3 more
openaire +3 more sources
Sigma-1 Receptor Plays a Negative Modulation on N-type Calcium Channel
Frontiers in Pharmacology, 2017 The sigma-1 receptor is a 223 amino acids molecular chaperone with a single transmembrane domain. It is resident to eukaryotic mitochondrial-associated endoplasmic reticulum and plasma membranes.
Kang Zhang +7 more
doaj +1 more source
Regulating ankyrin dynamics: Roles of sigma-1 receptors [PDF]
Proceedings of the National Academy of Sciences, 2001 Ankyrin is a cytoskeletal adaptor protein that controls important cellular functions, including Ca 2+ efflux at inositol 1,4,5-trisphosphate receptors (IP 3 R) on the endoplasmic reticulum. The present study found that sigma-1 receptors (Sig-1R), unique endoplasmic reticulum proteins that
T, Hayashi, T P, Su
openaire +2 more sources
Sigma-1 receptor: The novel intracellular target of neuropsychotherapeutic drugs
Journal of Pharmacological Sciences, 2015 Sigma-1 receptor ligands have been long expected to serve as drugs for treatment of human diseases such as neurodegenerative disorders, depression, idiopathic pain, drug abuse, and cancer.
Teruo Hayashi
doaj +1 more source