Results 11 to 20 of about 821,630 (331)
Role of sigma-1 receptors in neurodegenerative diseases
Journal of Pharmacological Sciences, 2015 Neurodegenerative diseases with distinct genetic etiologies and pathological phenotypes appear to share common mechanisms of neuronal cellular dysfunction, including excitotoxicity, calcium dysregulation, oxidative damage, ER stress and mitochondrial ...
Linda Nguyen +6 more
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Frontiers in Pharmacology, 2019 Sigma receptors, including Sigma-1 receptors and Sigma-2 receptors, are highly expressed in the CNS. They are intracellular chaperone proteins. Sigma-1 receptors localize mainly at the mitochondria-associated endoplasmic reticulum (ER) membrane (MAM ...
Kai Yang +3 more
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The cholinergic system, sigma-1 receptors and cognition [PDF]
Behavioural Brain Research, 2011 This article provides an overview of present knowledge regarding the relationship between the cholinergic system and sigma-1 receptors, and discusses potential applications of sigma-1 receptor agonists in the treatment of memory deficits and cognitive disorders.
Aren, van Waarde +7 more
openaire +4 more sources
Endoplasmic reticulum stress, autophagy, neuroinflammation, and sigma 1 receptors as contributors to depression and its treatment [PDF]
Neural Regeneration ResearchThe etiological factors contributing to depression and other neuropsychiatric disorders are largely undefined. Endoplasmic reticulum stress pathways and autophagy are well-defined mechanisms that play critical functions in recognizing and resolving ...
Chika Fujii +2 more
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Psychedelics and immunomodulation: Novel approaches and therapeutic opportunities [PDF]
Frontiers in Immunology, 2015 Classical psychedelics are psychoactive substances, which, besides their psychopharmacological activity, have also been shown to exert significant modulatory effects on immune responses by altering signaling pathways involved in inflammation, cellular ...
Attila eSzabo
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Fluvoxamine monotherapy for psychotic depression: the potential role of sigma-1 receptors [PDF]
Annals of General Psychiatry, 2009 Background Psychotic depression is a clinical subtype of major depressive disorder. A number of clinical studies have demonstrated the efficacy of the combination of an antidepressant (for example, a tricyclic antidepressant or selective serotonin ...
Hashimoto Kenji, Furuse Tsutomu
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The Sigma 2 receptor promotes and the Sigma 1 receptor inhibits mu-opioid receptor-mediated antinociception [PDF]
Molecular Brain, 2020 The Sigma-1 receptor (σ1R) has emerged as an interesting pharmacological target because it inhibits analgesia mediated by mu-opioid receptors (MOR), and also facilitates the development of neuropathic pain.
Pilar Sánchez-Blázquez +4 more
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Orphan receptor and chaperon functions of sigma-1 receptor
Folia Pharmacologica Japonica, 2014 Kohji Fukunaga
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The pharmacology of sigma-1 receptors. [PDF]
Pharmacol Ther, 2009 Originally considered an enigmatic protein, the sigma-1 receptor has recently been identified as a unique ligand-regulated molecular chaperone in the endoplasmic reticulum of cells. This discovery causes us to look back at the many proposed roles of this receptor, even before its molecular function was identified, in many diseases such as ...
Maurice T, Su TP.
europepmc +4 more sources
Sigma-1 Receptors Fine-Tune the Neuronal Networks. [PDF]
Adv Exp Med Biol, 2017 The endoplasmic reticular (ER) protein sigma-1 receptor (Sig-1R) has been implicated in CNS disorders including but not limited to neurodegenerative diseases, depression , amnesia, and substance abuse. Sig-1Rs are particularly enriched in the specific domain where ER membranes make contacts with the mitochondria (MAM).
Tsai SA, Su TP.
europepmc +4 more sources