Results 41 to 50 of about 1,199,100 (293)
Sigma 1 Receptor Co-Localizes with NRF2 in Retinal Photoreceptor Cells
Antioxidants, 2021 Sigma 1 receptor (Sig1R), a modulator of cell survival, has emerged as a novel target for retinal degenerative disease. Studies have shown that activation of Sig1R, using the high affinity ligand (+)-pentazocine ((+)-PTZ), improves cone function in a ...
Shannon R. Barwick +6 more
doaj +1 more source
Sigma-2 ligands induce tumour cell death by multiple signalling pathways [PDF]
, 2012 BACKGROUND: The sigma-2 receptor has been identified as a biomarker of proliferating cells in solid tumours. In the present study, we studied the mechanisms of sigma-2 ligand-induced cell death in the mouse breast cancer cell line EMT-6 and the human ...
Chang, Katherine +9 more
core +2 more sources
Analgesia induced by the epigenetic drug, L-acetylcarnitine, outlasts the end of treatment in mouse models of chronic inflammatory and neuropathic pain [PDF]
, 2017 Background: L-acetylcarnitine, a drug marketed for the treatment of chronic pain, causes analgesia by epigenetically up-regulating type-2 metabotropic glutamate (mGlu2) receptors in the spinal cord.
Battaglia, Giuseppe +10 more
core +1 more source
Psychopharmacology, 2014 Sigma-1 (σ1) receptor inhibition ameliorates neuropathic pain by inhibiting central sensitization. However, it is unknown whether σ1 receptor inhibition also decreases inflammatory hyperalgesia, or whether peripheral σ1 receptors are involved in this process.The purpose of this study was to determine the role of σ1 receptors in carrageenan-induced ...
Tejada, Miguel Ángel +6 more
openaire +3 more sources
Inhibition of alpha oscillations through serotonin-2A receptor activation underlies the visual effects of ayahuasca in humans [PDF]
, 2016 Ayahuasca is an Amazonian psychotropic plant tea typically obtained from two plants, Banisteriopsis caapi and Psychotria viridis. It contains the psychedelic 5-HT2A and sigma-1 agonist N,N-dimethyltryptamine (DMT) plus ß-carboline alkaloids with ...
Alonso, Joan Francesc +12 more
core +3 more sources
Sigma‐1 receptor modulation of opioid receptor signaling
The FASEB Journal, 2006 Sigma‐1 receptors (S1R) have been linked to numerous, diverse biological phenomena. However, current knowledge of S1R biology remains largely descriptive, and no clear molecular mechanisms of S1R action have been established. Previous work from our laboratory showed that S1R peptide ligands could modulate opiate analgesia in vivo. Opioid receptors have
Felix J Kim +2 more
openaire +1 more source
Frontiers in Pharmacology, 2017 Drug addiction is a chronic, debilitating disease that affects millions of people around the world causing a substantial societal burden. Despite decades of research efforts, treatment possibilities remain limited and relapse represents the most ...
Anna M. Klawonn +7 more
doaj +1 more source
Quinolones modulate ghrelin receptor signaling: potential for a novel small molecule scaffold in the treatment of cachexia [PDF]
, 2018 Cachexia is a metabolic wasting disorder characterized by progressive weight loss, muscle atrophy, fatigue, weakness, and appetite loss. Cachexia is associated with almost all major chronic illnesses including cancer, heart failure, obstructive ...
Cano, Rafael +8 more
core +3 more sources
Mediators of Inflammation, 2015 Previous studies have demonstrated that sigma-1 receptor plays important roles in the induction phase of rodent neuropathic pain; however, whether it is involved in bone cancer pain (BCP) and the underlying mechanisms remain elusive.
Shanshan Zhu +5 more
doaj +1 more source
Sigma-1 Receptors Fine-Tune the Neuronal Networks [PDF]
, 2017 The endoplasmic reticular (ER) protein sigma-1 receptor (Sig-1R) has been implicated in CNS disorders including but not limited to neurodegenerative diseases, depression , amnesia, and substance abuse. Sig-1Rs are particularly enriched in the specific domain where ER membranes make contacts with the mitochondria (MAM).
Shang-Yi Anne, Tsai, Tsung-Ping, Su
openaire +2 more sources