Results 31 to 40 of about 1,199,100 (293)
Journal of Pharmacological Sciences, 2013 Depression is associated with a substantial increase in the risk of developing heart failure and is independently associated with increased cardiovascular morbidity and mortality. Inversely, cardiovascular disease can lead to severe depression.
Md. Shenuarin Bhuiyan +2 more
doaj +1 more source
Sigma-1 Receptors in Depression: Mechanism and Therapeutic Development
Frontiers in Pharmacology, 2022 Depression is the most common type of neuropsychiatric illness and has increasingly become a major cause of disability. Unfortunately, the recent global pandemic of COVID-19 has dramatically increased the incidence of depression and has significantly ...
Peng Ren +7 more
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The cholinergic system, sigma-1 receptors and cognition [PDF]
Behavioural Brain Research, 2011 This article provides an overview of present knowledge regarding the relationship between the cholinergic system and sigma-1 receptors, and discusses potential applications of sigma-1 receptor agonists in the treatment of memory deficits and cognitive disorders.
Aren, van Waarde +7 more
openaire +2 more sources
An Evaluation of the Relationship between Sigma-1 and Sigma-2 Receptors and the Endocannabinoid System [PDF]
, 2016 Within the past two decades, sigma receptors have become a popular area for research. Although much has been learned about their structure, subtypes, and functions; there is still much to be learned.
Miller, Jenn
core +12 more sources
Pridopidine protects neurons from mutant-huntingtin toxicity via the sigma-1 receptor
Neurobiology of Disease, 2019 Huntington's disease (HD) is a neurodegenerative disease caused by a CAG repeat expansion in the Huntingtin gene (HTT), translated into a Huntingtin protein with a polyglutamine expansion.
Chelsy R. Eddings +5 more
doaj +1 more source
Fluvoxamine may prevent onset of psychosis: a case report of a patient at ultra-high risk of psychotic disorder [PDF]
, 2011 Background There is emerging evidence that antidepressants may be effective in preventing patients with non-specific and psychotic-like prodromal symptoms, defined as patients at ultra-high risk (UHR) of psychotic disorder, from transitioning to ...
Shigenori Tadokoro +4 more
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PLoS ONE, 2008 BackgroundSelective serotonin reuptake inhibitors (SSRIs) have been widely used and are a major therapeutic advance in psychopharmacology. However, their pharmacology is quite heterogeneous.
Tomoko Nishimura +3 more
doaj +1 more source
Frontiers in Pharmacology, 2019 Sigma receptors, including Sigma-1 receptors and Sigma-2 receptors, are highly expressed in the CNS. They are intracellular chaperone proteins. Sigma-1 receptors localize mainly at the mitochondria-associated endoplasmic reticulum (ER) membrane (MAM ...
Kai Yang +3 more
doaj +1 more source
Cocaine Effects on Dopaminergic Transmission Depend on a Balance between Sigma-1 and Sigma-2 Receptor Expression. [PDF]
, 2018 gma σ1 and σ2 receptors are targets of cocaine. Despite sharing a similar name, the two receptors are structurally unrelated and their physiological role is unknown. Cocaine increases the level of dopamine, a key neurotransmitter in CNS motor control and
Aguinaga Andrés, David +6 more
core +1 more source
Orexin-Corticotropin-Releasing Factor Receptor Heteromers in the Ventral Tegmental Area as Targets for Cocaine [PDF]
, 2015 Release of the neuropeptides corticotropin-releasing factor (CRF) and orexin-A in the ventral tegmental area (VTA) play an important role in stress-induced cocaine-seeking behavior.
Aguinaga, David +17 more
core +1 more source