Results 11 to 20 of about 1,199,100 (293)
SIGMAR1/Sigma-1 receptor ablation impairs autophagosome clearance [PDF]
Autophagy, 2019 Autophagosome-lysosome fusion is a common critical step in various forms of macroautophagy/autophagy including mitophagy, the selective degradation of mitochondria. Regulations of this fusion process remain poorly defined. Here we have determined the role of SIGMAR1, a unique endoplasmic reticulum membrane protein.
Huan Yang, Lian-Wang Guo
exaly +4 more sources
Journal of Pharmacological Sciences, 2015 Endoplasmic reticulum (ER) protein sigma-1 receptor represents unique chaperone activity in the central nervous system, and it exerts a potent influence on a number of neurotransmitter systems. Several lines of evidence suggest that activation of sigma-1
Kenji Hashimoto
doaj +3 more sources
Sigma-1 receptor: The novel intracellular target of neuropsychotherapeutic drugs
Journal of Pharmacological Sciences, 2015 Sigma-1 receptor ligands have been long expected to serve as drugs for treatment of human diseases such as neurodegenerative disorders, depression, idiopathic pain, drug abuse, and cancer.
Teruo Hayashi
doaj +3 more sources
Allosteric Modulators of Sigma-1 Receptor: A Review [PDF]
Frontiers in Pharmacology, 2019 Allosteric modulators of sigma-1 receptor (Sig1R) are described as compounds that can increase the activity of some Sig1R ligands that compete with (+)-pentazocine, one of the classic prototypical ligands that binds to the orthosteric Sig1R binding site.
Edijs Vavers +3 more
doaj +3 more sources
Sigma-1 Receptor-Modulated Neuroinflammation in Neurological Diseases [PDF]
Frontiers in Cellular Neuroscience, 2018 A large body of evidence indicates that sigma-1 receptors (Sig-1R) are important drug targets for a number of neuropsychiatric disorders. Sig-1Rs are enriched in central nervous system (CNS). In addition to neurons, both cerebral microglia and astrocytes
Jia Jia +3 more
doaj +3 more sources
Sigma 1 Receptor, Cholesterol and Endoplasmic Reticulum Contact Sites [PDF]
Contact, 2021 Recent studies indicated potential importance of membrane contact sites (MCS) between the endoplasmic reticulum (ER) and other cellular organelles. These MCS have unique protein and lipid composition and serve as hubs for inter-organelle communication ...
Vladimir Zhemkov +2 more
doaj +3 more sources
The Sigma-1 Receptor in Cellular Stress Signaling [PDF]
Frontiers in Neuroscience, 2019 After decades of research, the sigma-1 receptor (Sig-1R)’s structure, and molecular functions are being unveiled. Sig-1R is an integral endoplasmic reticulum (ER) membrane protein which forms an oligomer and binds a variety of psychotropic drugs.
Teruo Hayashi
doaj +3 more sources
Cocaine inhibits dopamine D2 receptor signaling via sigma-1-D2 receptor heteromers.
PLoS ONE, 2013 Under normal conditions the brain maintains a delicate balance between inputs of reward seeking controlled by neurons containing the D1-like family of dopamine receptors and inputs of aversion coming from neurons containing the D2-like family of dopamine
Gemma Navarro +13 more
doaj +5 more sources
The pharmacology of sigma-1 receptors [PDF]
Pharmacology & Therapeutics, 2009 Originally considered an enigmatic protein, the sigma-1 receptor has recently been identified as a unique ligand-regulated molecular chaperone in the endoplasmic reticulum of cells. This discovery causes us to look back at the many proposed roles of this receptor, even before its molecular function was identified, in many diseases such as ...
Tangui, Maurice, Tsung-Ping, Su
openaire +2 more sources
Sigma-1 Receptor Chaperones and Diseases [PDF]
Central Nervous System Agents in Medicinal Chemistry, 2009 Chaperones are proteins that assist the correct folding of other protein clients either when the clients are being synthesized or at their functional localities. Chaperones are responsible for certain diseases. The sigma-1 receptor is recently identified as a receptor chaperone whose activity can be activated/deactivated by specific ligands.
Shang-Yi, Tsai +3 more
openaire +2 more sources