Results 21 to 30 of about 1,199,100 (293)
Biochemical Pharmacology of the Sigma-1 Receptor [PDF]
Molecular Pharmacology, 2016 The sigma-1 receptor (S1R) is a 223 amino acid two transmembrane (TM) pass protein. It is a non-ATP-binding nonglycosylated ligand-regulated molecular chaperone of unknown three-dimensional structure. The S1R is resident to eukaryotic mitochondrial-associated endoplasmic reticulum and plasma membranes with broad functions that regulate cellular calcium
Uyen B, Chu, Arnold E, Ruoho
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Sigma-1 receptor agonists directly inhibit Nav1.2/1.4 channels.
PLoS ONE, 2012 (+)-SKF 10047 (N-allyl-normetazocine) is a prototypic and specific sigma-1 receptor agonist that has been used extensively to study the function of sigma-1 receptors.
Xiao-Fei Gao +4 more
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International Journal of Cardiology: Heart & Vasculature, 2020 Sigma-1 receptors are ligand-regulated chaperone proteins, involved in several cellular mechanisms. The aim of this systematic review was to examine the effects that the sigma-1 receptor has on the cardiovascular system.
Rebecca Lewis +4 more
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Scientific Reports, 2023 Sigma-1 Receptor has been shown to localize to sites of peripheral nerve injury and back pain. Radioligand probes have been developed to localize Sigma-1 Receptor and thus image pain source.
Ethan Schonfeld +6 more
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3D-QSAR and docking studies of pentacycloundecylamines at the sigma-1 (σ1) receptor [PDF]
, 2013 Pentacycloundecylamine (PCU) derived compounds have been shown to be promising lead structures for the development of novel drug candidates aimed at a variety of neurodegenerative and psychiatric diseases.
Ablordeppey +31 more
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Defining the ligand-dependent proximatome of the sigma 1 receptor
Frontiers in Cell and Developmental Biology, 2023 Sigma 1 Receptor (S1R) is a therapeutic target for a wide spectrum of pathological conditions ranging from neurodegenerative diseases to cancer and COVID-19. S1R is ubiquitously expressed throughout the visceral organs, nervous, immune and cardiovascular
Jing Zhao +16 more
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Sigma-1 Receptor Plays a Negative Modulation on N-type Calcium Channel
Frontiers in Pharmacology, 2017 The sigma-1 receptor is a 223 amino acids molecular chaperone with a single transmembrane domain. It is resident to eukaryotic mitochondrial-associated endoplasmic reticulum and plasma membranes.
Kang Zhang +7 more
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Molecules, 2020 The sigma receptors were classified into sigma-1 and sigma-2 receptor based on their different pharmacological profiles. In the past two decades, our understanding of the biological and pharmacological properties of the sigma-1 receptor is increasing ...
Kai Yang +5 more
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Regulating ankyrin dynamics: Roles of sigma-1 receptors [PDF]
Proceedings of the National Academy of Sciences, 2001 Ankyrin is a cytoskeletal adaptor protein that controls important cellular functions, including Ca 2+ efflux at inositol 1,4,5-trisphosphate receptors (IP 3 R) on the endoplasmic reticulum. The present study found that sigma-1 receptors (Sig-1R), unique endoplasmic reticulum proteins that
T, Hayashi, T P, Su
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Rapid reduction of sigma(1)-Receptor binding and F-18-FDG uptake in rat gliomas after in vivo treatment with doxorubicin [PDF]
, 2007 sigma-Receptors are strongly overexpressed in most rodent and human tumors and are proliferation markers. To evaluate the potential of a radiolabeled sigma(1)-ligand for therapy monitoring, we compared early changes of C-11-1-(3,4-dimethoxyphenethyl)-4 ...
de Jong, Johan R. +5 more
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