Pharmacological Research, 2023 Over the last decade, sigma-1 receptor (Sig1R) has been recognized as a valid target for the treatment of seizure disorders and seizure-related comorbidities.
Edijs Vavers +2 more
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The Sigma 2 receptor promotes and the Sigma 1 receptor inhibits mu-opioid receptor-mediated antinociception [PDF]
Molecular Brain, 2020 The Sigma-1 receptor (σ1R) has emerged as an interesting pharmacological target because it inhibits analgesia mediated by mu-opioid receptors (MOR), and also facilitates the development of neuropathic pain.
Pilar Sánchez-Blázquez +4 more
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Pharmacological and Pathological Implications of Sigma-1 Receptor in Neurodegenerative Diseases [PDF]
BiomedicinesOriginally identified as a potential receptor for opioids, the sigma-1 receptor is now recognized as an intracellular chaperone protein associated with mitochondria-associated membranes at the endoplasmic reticulum (ER).
Noah Drewes +3 more
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The sigma-1 receptor as a neurohomeostatic decision hub for GABARAP-mediated receptor trafficking and macroautophagy [PDF]
Frontiers in Molecular BiosciencesGamma-aminobutyric acid receptor-associated protein (GABARAP) is a multifunctional member of the autophagy-related (ATG8) protein family, playing key roles in two distinct cellular pathways: macroautophagy and plasma membrane protein trafficking.
Marius Wilhelm Baeken +4 more
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Viewpoints Sigma-1 receptor agonist fluvoxamine for multiple sclerosis [PDF]
Brain, Behavior, & Immunity - HealthAccumulating evidence suggests that the Epstein-Barr virus (EBV) plays a key role in the development of multiple sclerosis (MS). Additionally, depressive symptoms often precede the onset of MS.
Kenji Hashimoto
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Psychedelic N,N-dimethyltryptamine and 5-methoxy-N,N-dimethyltryptamine modulate innate and adaptive inflammatory responses through the sigma-1 receptor of human monocyte-derived dendritic cells. [PDF]
, 2014 The orphan receptor sigma-1 (sigmar-1) is a transmembrane chaperone protein expressed in both the central nervous system and in immune cells. It has been shown to regulate neuronal differentiation and cell survival, and mediates anti-inflammatory ...
Frecska, Ede +3 more
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Frontiers in Pharmacology, 2020 Sigma-1 and sigma-2 receptors are emerging therapeutic targets. Although the molecular identity of the sigma-2 receptor has recently been determined, receptor quantitation has used, and continues to use, the sigma-1 selective agents (+) pentazocine or ...
Haider Abbas +5 more
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Highly Specific Sigma Receptor Ligands Exhibit Anti-Viral Properties in SARS-CoV-2 Infected Cells
Pathogens, 2021 (1) Background: There is a strong need for prevention and treatment strategies for COVID-19 that are not impacted by SARS-CoV-2 mutations emerging in variants of concern.
David A. Ostrov +15 more
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Frontiers in Pharmacology, 2021 In traumatic spinal cord injury, the initial trauma is followed by a cascade of impairments, including excitotoxicity and calcium overload, which ultimately induces secondary damages. The sigma-1 receptor is widely expressed in the central nervous system
Alise Lattard +6 more
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TMEM97 and PGRMC1 do not mediate sigma-2 ligand-induced cell death [PDF]
, 2019 Sigma-2 receptors have been implicated in both tumor proliferation and neurodegenerative diseases. Recently the sigma-2 receptor was identified as transmembrane protein 97 (TMEM97).
Hawkins, William G. +9 more
core +3 more sources