Results 231 to 240 of about 34,646 (246)
Hrs, a Mammalian Master Molecule in Vesicular Transport and Protein Sorting, Suppresses the Degradation of ESCRT Proteins Signal Transducing Adaptor Molecule 1 and 2 [PDF]
Journal of Biological Chemistry, 2005 The degradation and sorting of cytoplasmic and cell-surface proteins are crucial steps in the control of cellular functions. We previously identified three mammalian Vps (vacuolar protein sorting) proteins, Hrs (hepatocyte growth factor-regulated tyrosine kinase substrate) and signal transducing adaptor molecule (STAM) 1 and -2, which are tyrosine ...
Nobuyuki Tanaka +2 more
exaly +3 more sources
Biological and Pharmaceutical Bulletin, 2008 Signal-transducing adaptor protein-2 (STAP-2) is a recently identified adaptor protein as a c-Fms/M-CSF receptor-interacting protein and constitutively expressed in macrophages. In our previous study, we examined the role of STAP-2 in the c-Fms/M-CSF receptor signaling using a murine macrophage tumor cells line, Raw264.7.
Yuichi Sekine +2 more
exaly +5 more sources
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Biochemical and Biophysical Research Communications, 2021
Graft-versus-host disease (GVHD) is the most frequent complication after allogeneic hematopoietic stem cell transplantation (HSCT), and is one of the major causes of non-relapse mortality. Transferred mature lymphocytes are thought to be responsible for GVHD based on the findings that mice transplanted with lymphocyte-depleted bone marrow (BM) cells ...
Hideaki Saito +2 more
exaly +3 more sources
Graft-versus-host disease (GVHD) is the most frequent complication after allogeneic hematopoietic stem cell transplantation (HSCT), and is one of the major causes of non-relapse mortality. Transferred mature lymphocytes are thought to be responsible for GVHD based on the findings that mice transplanted with lymphocyte-depleted bone marrow (BM) cells ...
Hideaki Saito +2 more
exaly +3 more sources
Signal-transducing adaptor protein-2 modulates T-cell functions
Exploration of ImmunologyImmune responses are orchestrated by controlling the initiation, magnitude, and duration of various signaling pathways. Adaptor proteins act as positive or negative regulators by targeting critical molecules of signaling cascades. Signal-transducing adaptor protein-2 (STAP-2) contains typical features of adaptor proteins, like a pleckstrin homology (PH)
Tadashi Matsuda +2 more
exaly +1 more source
ESCRT-0 Protein Hepatocyte Growth Factor-regulated Tyrosine Kinase Substrate (Hrs) Is Targeted to Endosomes Independently of Signal-transducing Adaptor Molecule (STAM) and the Complex Formation with STAM Promotes Its Endosomal Dissociation [PDF]
Journal of Biological Chemistry, 2014 The ESCRT-0 complex, consisting of the hepatocyte growth factor-regulated tyrosine kinase substrate (Hrs) and the signal-transducing adaptor molecule (STAM) proteins, recognizes ubiquitylated cargo during the initial step of endosomal sorting. The endosomal accumulation of overexpressed Hrs has been reported previously to be associated with endosome ...
Katsuhiko Kojima +2 more
exaly +4 more sources
The Journal of Immunology
Abstract Signal-transducing adaptor protein (STAP)-1 is an adaptor protein that is widely expressed in T cells. In this article, we show that STAP-1 upregulates TCR-mediated T cell activation and T cell–mediated airway inflammation. Using STAP-1 knockout mice and STAP-1–overexpressing Jurkat cells, we found that STAP-1 enhanced TCR ...
Kota Kagohashi +14 more
openaire +2 more sources
Abstract Signal-transducing adaptor protein (STAP)-1 is an adaptor protein that is widely expressed in T cells. In this article, we show that STAP-1 upregulates TCR-mediated T cell activation and T cell–mediated airway inflammation. Using STAP-1 knockout mice and STAP-1–overexpressing Jurkat cells, we found that STAP-1 enhanced TCR ...
Kota Kagohashi +14 more
openaire +2 more sources
STAP-2 Adaptor Protein Regulates Multiple Steps of Immune and Inflammatory Responses
Biological and Pharmaceutical Bulletin, 2021Tadashi Matsuda, Kenji Oritani
exaly
Adaptor Protein STAP-2 Modulates Cellular Signaling in Immune Systems
Biological and Pharmaceutical Bulletin, 2014Yuichi Sekine
exaly
Cloning of a Novel Signal-Transducing Adaptor Molecule Containing an SH3 Domain and ITAM
Biochemical and Biophysical Research Communications, 1996Toshikazu Takeshita +2 more
exaly