Results 21 to 30 of about 517,159 (303)

Novel Signal Amplification Technology with Applications in DNA and Protein Detection Systems

BioTechniques, 2001
A non-enzymatic approach to signal amplification has practical advantages over conventional target amplification methods. We have designed a simple, cost-efficient signal amplification system that can be used to enhance the detection of nucleic acids or ...
C.M. Lisle, S. Bortolin, A.S. Benight, R.A. Janeczko, R.L. Zastawny   +4 more
doaj   +1 more source

Signal amplification by rolling circle amplification on DNA microarrays [PDF]

Nucleic Acids Research, 2001
While microarrays hold considerable promise in large-scale biology on account of their massively parallel analytical nature, there is a need for compatible signal amplification procedures to increase sensitivity without loss of multiplexing. Rolling circle amplification (RCA) is a molecular amplification method with the unique property of product ...
G, Nallur, C, Luo, L, Fang, S, Cooley, V, Dave, J, Lambert, K, Kukanskis, S, Kingsmore, R, Lasken, B, Schweitzer   +9 more
openaire   +2 more sources

MiRNA Detection Using a Rolling Circle Amplification and RNA-Cutting Allosteric Deoxyribozyme Dual Signal Amplification Strategy

Biosensors, 2021
A microRNA (miRNA) detection platform composed of a rolling circle amplification (RCA) system and an allosteric deoxyribozyme system is proposed, which can detect miRNA-21 rapidly and efficiently.
Chenxin Fang, Ping Ouyang, Yuxing Yang, Yang Qing, Jialun Han, Wenyan Shang, Yubing Chen, Jie Du   +7 more
doaj   +1 more source

Electrochemical Signal Amplification Strategies and Their Use in Olfactory and Taste Evaluation

Biosensors, 2022
Biosensors are powerful analytical tools used to identify and detect target molecules. Electrochemical biosensors, which combine biosensing with electrochemical analysis techniques, are efficient analytical instruments that translate concentration ...
Xinqian Wang, Dingqiang Lu, Yuan Liu, Wenli Wang, Ruijuan Ren, Ming Li, Danyang Liu, Yujiao Liu, Yixuan Liu, Guangchang Pang   +9 more
doaj   +1 more source

Laser Enhanced Ionization of Mercury Atoms in an Inert Atmosphere with Avalanche Amplification of the Signal. [PDF]

, 1997
A new method for laser enhanced ionization detection of mercury atoms in an inert gas atmosphere is described. The method, which is based on the avalanche amplification of the signal resulting from the ionization from a selected Tydberg level reached by ...
Winefordner, J.D., MATVEEV Oleg, SMITH B.W., CABREDO Susana, CLEVENGER W.L., Cabredo, S. [0000-0002-8828-4700], OMENETTO Nicolo', SMITH B. W., WINEFORDNER James, Smith, B.W. [0000-0003-1215-4093], Omenetto, N., Clevenger, W.L., Matveev, O.I.   +12 more
core   +1 more source

SARS-CoV-2 RNA Detection with Duplex-Specific Nuclease Signal Amplification

Micromachines, 2021
The emergence of the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), a zoonotic pathogen, has led to the outbreak of coronavirus disease 2019 (COVID-19) pandemic and brought serious threats to public health worldwide.
Meiqing Liu, Haoran Li, Yanwei Jia, Pui-In Mak, Rui P. Martins   +4 more
doaj   +1 more source

Phosphorelays provide tunable signal processing capabilities for the cell [PDF]

, 2013
Achieving a complete understanding of cellular signal transduction requires deciphering the relation between structural and biochemical features of a signaling system and the shape of the signal-response relationship it embeds.
Luca Cardelli, Elisenda Feliu (481165), Carsten Wiuf (40596), Soyer, Orkun S, Orkun S. Soyer (242985), Varun B. Kothamachu (481164), Cardelli Luca, Orkun S. Soyer, Feliu Elisenda, Wiuf Carsten, Kothamachu, Varun B., Cardelli, Luca, Soyer, Orkun S., Luca Cardelli (191712), Elisenda Feliu, Varun B Kothamachu, Carsten Wiuf, Kothamachu, Varun B, Varun B. Kothamachu, Soyer Orkun S., Orkun S Soyer, Kothamachu Varun B., Feliu, Elisenda, Wiuf, Carsten   +23 more
core   +1 more source

Amplification Characteristics of a Coumarin 460-Based Tunable Amplifier

IEEE Photonics Journal, 2020
We studied the optical signal amplification properties of coumarin 460 (C460) in solution. An optical signal amplification experiment was performed using a side-pumping setup.
Jianping Shen, Wei Wang, Siwei Zhang
doaj   +1 more source

Signal amplification in the KEAP1-NRF2-ARE antioxidant response pathway

Redox Biology, 2022
The KEAP1-NRF2-ARE signaling pathway plays a central role in mediating the adaptive cellular stress response to oxidative and electrophilic chemicals. This canonical pathway has been extensively studied and reviewed in the past two decades, but rarely ...
Shengnan Liu, Jingbo Pi, Qiang Zhang
doaj   +1 more source

Efficient binary phase quantizer based on phase sensitive four wave mixing [PDF]

, 2014
We experimentally demonstrate an efficient binary phase quantizer operating at low pump powers. Phase-sensitive operation is obtained by polarization mixing the phase-locked signal/idler pair in a degenerate dual-pump vector parametric ...
Horak, P., P. Horak, Hesketh, G., D. J. Richardson, Parmigiani, F., Slavík, R., Petropoulos, P., F. Parmigiani, Richardson, D.J., P. Petropoulos, G. Hesketh, R. Slavik   +11 more
core   +1 more source