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Signal transducer and activator of transcription 3 signaling in tumor immune evasion
Pharmacology & Therapeutics, 2022The underlying mechanism of tumor immune evasion is a highly concerning subject for researchers. Increasing evidences reveal that the over-activated signal transducer and activator of transcription 3 (STAT3) is a crucial molecular hub in malignant tumors.
Zhang, Luying +8 more
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Signal transducer and activator of transcription proteins in leukemias
Blood, 2003AbstractSignal transducer and activator of transcription (STAT) proteins are a 7-member family of cytoplasmic transcription factors that contribute to signal transduction by cytokines, hormones, and growth factors. STAT proteins control fundamental cellular processes, including survival, proliferation, and differentiation.
Mustafa, Benekli +3 more
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Signal Transducers and Activators of Transcription in Cytokine Signaling
2003Hematopoiesis is regulated through the action of a variety of growth factors that share in common the utilization of receptors of the cytokine receptor superfamily. This family of receptors shares in common structural motifs in the extracellular and intracellular regions and, where examined, have common three dimensional elements.
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