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The Role of Signal Transducer and Activator of Transcription Factors in Leukemogenesis
Journal of Clinical Oncology, 2004Human leukemias are frequently associated with the aberrant expression of activated fusion tyrosine kinases or activated protein tyrosine kinases carrying insertional or point mutations. The activated kinase enzymes typically phosphorylate one or more signal transducer and activator of transcription (STAT) factors, which translocate to the cell ...
David W, Sternberg, D Gary, Gilliland
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Dysregulatory syndromes: the role of signal transducers and activators of transcription
Current Opinion in Pediatrics, 2018Purpose of review A comparative description of dysregulatory syndromes with mutations in signal transducer and activator of transcription (STAT) genes. Recent findings STAT 1, 3 and 5b loss of function (LOF) and gain of function (GOF) mutations are a heterogeneous group of genetic ...
Liliana, Bezrodnik +2 more
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Signal Transducers and Activators of Transcription in Cytokine Signaling
2003Hematopoiesis is regulated through the action of a variety of growth factors that share in common the utilization of receptors of the cytokine receptor superfamily. This family of receptors shares in common structural motifs in the extracellular and intracellular regions and, where examined, have common three dimensional elements.
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Signal transducers and activators of transcription—from cytokine signalling to cancer biology
Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, 2011Signal transducers and activators of transcription (STATs) are, as the name indicates, both signal transducers and transcription factors. STATs are activated by cytokines and some growth factors and thus control important biological processes. These include cell growth, cell differentiation, apoptosis and immune responses.
Cristina Isabel, Santos +1 more
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The role of signal transducers and activators of transcription in colon cancer
Frontiers in Bioscience, 2008A family of latent cytoplasmic transcription factors, Signal Transducers and Activators of Transcription (STATs), convey signals from numerous cytokines and growth factors to the nucleus. Their expression and their activity have been shown to be perturbed in a variety of malignancies, including colorectal cancer.
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MicroRNAs and signal transducers and activators of transcription
Academic Journal of Second Military Medical University, 2013Sha XU, Hou-qi LIU
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