Statement of Retraction: Homeodomain-containing gene 10 contributed to breast cancer malignant behaviors by activating Interleukin-6/Janus kinase 2/Signal transducer and activator of transcription 3 pathway. [PDF]
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Signal transducer and activator of transcription signals in allergic disease
Journal of Allergy and Clinical Immunology, 2007Signal transducer and activator of transcription (STAT) proteins are a group of transcription factors that transmit signals from the extracellular milieu of cells to the nucleus. They are crucial for the signaling of many cytokines that are mediators of allergic inflammation and impact various cell types critical to allergy including epithelial cells ...
Weiguo, Chen, Gurjit K, Khurana Hershey
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Signal transducer and activator of transcription proteins in leukemias
Blood, 2003AbstractSignal transducer and activator of transcription (STAT) proteins are a 7-member family of cytoplasmic transcription factors that contribute to signal transduction by cytokines, hormones, and growth factors. STAT proteins control fundamental cellular processes, including survival, proliferation, and differentiation.
Mustafa, Benekli +3 more
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Signal transducer and activator of transcription 5 (STAT5)
The International Journal of Biochemistry & Cell Biology, 2004Signal transducer and activator of transcription 5 (STAT5) activity is induced by a plethora of cytokines and growth factors resulting in transcriptional activation of specific target genes. STAT5 plays an important role in a variety of cellular processes, including proliferation, differentiation, and apoptosis.
Miranda, Buitenhuis +2 more
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Impaired natural killer cell functions in patients with signal transducer and activator of transcription 1 (STAT1) gain-of-function mutations [PDF]
Journal of Allergy and Clinical Immunology, 2017 Gain-of-function (GOF) mutations affecting the coiled-coil domain or the DNA-binding domain of signal transducer and activator of transcription 1 (STAT1) cause chronic mucocutaneous candidiasis disease.
Raffaele Badolato +2 more
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Involvement of signal transducers and activators of transcription in trophoblast differentiation
Placenta, 2021To explore the involvement of signal transducers and activators of transcription (STATs) in trophoblast differentiation.First, the localization of STATs in human placentas was detected via immunohistochemistry (IHC) and immunofluorescence (IF). Cytotrophoblasts (CTBs) expressed both STAT1 and 3, but syncytiotrophoblasts (STBs) did not.
Chao, Chen +5 more
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Signal transducer and activator of transcription 3 signaling in tumor immune evasion
Pharmacology & Therapeutics, 2022The underlying mechanism of tumor immune evasion is a highly concerning subject for researchers. Increasing evidences reveal that the over-activated signal transducer and activator of transcription 3 (STAT3) is a crucial molecular hub in malignant tumors.
Zhang, Luying +8 more
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The Role of Signal Transducer and Activator of Transcription Factors in Leukemogenesis
Journal of Clinical Oncology, 2004Human leukemias are frequently associated with the aberrant expression of activated fusion tyrosine kinases or activated protein tyrosine kinases carrying insertional or point mutations. The activated kinase enzymes typically phosphorylate one or more signal transducer and activator of transcription (STAT) factors, which translocate to the cell ...
David W, Sternberg, D Gary, Gilliland
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Signal Transducers and Activators of Transcription in Cytokine Signaling
2003Hematopoiesis is regulated through the action of a variety of growth factors that share in common the utilization of receptors of the cytokine receptor superfamily. This family of receptors shares in common structural motifs in the extracellular and intracellular regions and, where examined, have common three dimensional elements.
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Dysregulatory syndromes: the role of signal transducers and activators of transcription
Current Opinion in Pediatrics, 2018Purpose of review A comparative description of dysregulatory syndromes with mutations in signal transducer and activator of transcription (STAT) genes. Recent findings STAT 1, 3 and 5b loss of function (LOF) and gain of function (GOF) mutations are a heterogeneous group of genetic ...
Liliana, Bezrodnik +2 more
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