Results 261 to 270 of about 146,182 (290)

The AUTACE That Degrades KRAS and Engages CD8+ T Cells for the Treatment of KRAS/TP53 Co‐Mutant Tumors

Advanced Science, EarlyView.
AUTACE is a bifunctional nanoplatform that integrates tumor targeting, immune engagement, and on‐demand KRAS degradation. It targets KRAS/TP53 co‐mutant tumors via TP53‐specific TCRs, elicits antitumor CD8+ T‐cell responses through surface anti‐CD3 antibodies, and uses low‐intensity focused ultrasound (LIFU) to trigger controlled release of the KRAS ...
Luo Li, Bolin Li, Yanan Hao, Bo Pang, Pan Li, Chunli Li, Yu Tang   +6 more
wiley   +1 more source

Context‐Dependent Role of GDF15: GDF15+ Tumor‐Associated Macrophages Suppress OSCC Progression by Enhancing Phagocytosis

Advanced Science, EarlyView.
This study identifies GDF15+ TAMs as a cell subset mediating tumor regression after immunotherapy. Macrophage‐intrinsic GDF15 enhances phagocytosis and antigen cross‐presentation to CD8+ T cells through the NF‐κB signaling pathway, thereby inhibiting tumor progression.
Xinyu Zhou, Zhihang Zhou, Houyu Ju, Chaoyang Guo, Fangxing Zhu, Yiyi Zhang, Xu Chen, Tongchao Zhao, Laiping Zhong, Jingzhou Hu   +9 more
wiley   +1 more source

Tetrastigma Hemsleyanum Polysaccharide Suppresses Triple‐Negative Breast Cancer by Disrupting the Hippo‐YAP/TEAD4‐PDIA4 Axis and Endoplasmic Reticulum Stress Adaptation

Advanced Science, EarlyView.
ABSTRACT Triple‐negative breast cancer (TNBC) exhibits addiction to chronic endoplasmic reticulum (ER) stress, which sustains an aggressive metastatic phenotype through activation of the unfolded protein response (UPR). Here, we identify a previously unrecognized “ER‐stress addiction” axis in which the Hippo pathway effector TEAD4 directly ...
Yini Shang, Wentao Si, Youxue Zhang, Jialin Liu, Huaixi Zhang, Yafei Li, Hongmeng Su, Wei Jiang, Zhishan Ding, Lihong Wang   +9 more
wiley   +1 more source

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Signal transducer and activator of transcription 3 signaling in tumor immune evasion

Pharmacology & Therapeutics, 2022
The underlying mechanism of tumor immune evasion is a highly concerning subject for researchers. Increasing evidences reveal that the over-activated signal transducer and activator of transcription 3 (STAT3) is a crucial molecular hub in malignant tumors.
Zhang, Luying, Kuca, Kamil, You, Li, Zhao, Yingying, Musilek, Kamil, Nepovimova, Eugenie, Wu, Qinghua, Wu, Wenda, Adam, Vojtech   +8 more
openaire   +3 more sources

Signal Transducer and Activator of Transcription 3 Promotes Leukemogenesis

Blood, 2011
Abstract Abstract 1395 We have previously shown that constitutive activation of the signal transducer and activator of transcription (STAT) 3 protein is associated with worse outcome in patients with acute myeloid leukemia (AML).
Sampa Ghoshal, Michael T Brady, Omar Ustwani, Erin Tracy, Jason Den Haese, Paul K. Wallace, Heinz Baumann, Meir Wetzler   +7 more
openaire   +1 more source

Antitumor Activity of Novel Signal Transducer and Activator of Transcription 3 Inhibitors on Retinoblastoma

Molecular Pharmacology, 2021
Signal transducer and activator of transcription 3 (STAT3) is a plausible therapeutic target in the treatment of retinoblastoma, the most common intraocular malignant tumor in children. STAT3, a transcription factor of several genes related to tumorigenesis, is activated in retinoblastoma tumors as well as other cancers.
Dong Hyun, Jo, Seungbeom, Lee, Eunoo, Bak, Chang Sik, Cho, Young Taek, Han, Kyeojin, Kim, Young-Ger, Suh, Jeong Hun, Kim   +7 more
openaire   +2 more sources

Signal transducer and activator of transcription 3 (Stat3) in epithelial carcinogenesis

Molecular Carcinogenesis, 2007
AbstractSignal transducer and activator of transcription 3 (Stat3) is one of a family of cytoplasmic proteins that participate in normal cellular responses to cytokines and growth factors as transcription factors. Stat3 modulates various physiological functions including cell survival, cell‐cycle regulation, and angiogenesis through regulation of gene ...
Dae Joon, Kim, Keith S, Chan, Shigetoshi, Sano, John, Digiovanni   +3 more
openaire   +2 more sources

Signal transducer and activator of transcription 3 inhibitors: a patent review

Expert Opinion on Therapeutic Patents, 2010
Aberrant activation of signal transducer and activator of transcription (Stat) 3, a member of the STAT family of proteins, is prevalent in numerous human cancers and is now widely recognized as a critical molecular abnormality and a master regulator of tumor processes.
Brent D G, Page, Daniel P, Ball, Patrick T, Gunning   +2 more
openaire   +2 more sources

Microtubule-Targeted Chemotherapeutic Agents Inhibit Signal Transducer and Activator of Transcription 3 (STAT3) Signaling

Molecular Pharmacology, 2010
The transcription factor signal transducer and activator of transcription 3 (STAT3) is inappropriately activated in the majority of breast tumors, especially in aggressive and invasive ones. In addition to driving the expression of genes promoting malignancy, STAT3 associates with tubulin and can promote cell migration.
Sarah R, Walker, Mousumi, Chaudhury, Erik A, Nelson, David A, Frank   +3 more
openaire   +2 more sources

Constitutive activation of signal transducer and activator of transcription 3 in epithelial ovarian carcinoma

Journal of Obstetrics and Gynaecology Research, 2009
AbstractAim:  To investigate the expressions of signal transducer and activator of transcription 3 (Stat3) and tyrosine‐activated Stat3 (p‐Stat3) in epithelial ovarian carcinoma (EOC) and their relationships with clinical pathological parameters or prognosis.Methods:  Immunohistochemical methods were used to detect the expressions of Stat3 and p‐Stat3 ...
Hao, Min, Zhao, Wei-hong
openaire   +2 more sources