Results 21 to 30 of about 1,137,727 (346)
Isolation of tissue-resident endothelial stem cells and their use in regenerative medicine
Inflammation and Regeneration, 2019 Background During sprouting angiogenesis, stalk cells, localized behind tip cells, generate endothelial cells (ECs) for the elongation of new vessels.
Tomohiro Iba +5 more
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Nature Communications, 2021 Protein ubiquitylation is often studied by proteomics but how data independent acquisition (DIA) may advance these studies remains to be explored. Here, the authors show that DIA improves ubiquitylation site identification and quantification, enabling ...
Fynn M. Hansen +8 more
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Scientific Reports, 2022 The initiation of heartbeat is an essential step in cardiogenesis in the heart primordium, but it remains unclear how intracellular metabolism responds to increased energy demands after heartbeat initiation.
Tatsuya Sato +6 more
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Stem Cell Research & Therapy, 2023 Background A resident vascular endothelial stem cell (VESC) population expressing CD157 and CD200 has been identified recently in the adult mouse. However, the origin of this population and how it develops has not been characterized, nor has it been ...
Fitriana N. Rahmawati +6 more
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Enzyme localization can drastically affect signal amplification in signal transduction pathways [PDF]
, 2005 Push-pull networks are ubiquitous in signal transduction pathways in both prokaryotic and eukaryotic cells. They allow cells to strongly amplify signals via the mechanism of zero-order ultrasensitivity.
van Albada, Siebe B. +1 more
core +5 more sources
Ras p21 protein promotes survival and fiber outgrowth of cultured embryonic neurons [PDF]
, 1989 Although evidence obtained with the PC12 cell line has suggested a role for the ras oncogene proteins in the signal transduction of nerve growth factor-mediated fiber outgrowth, little is known about the signal transduction mechanisms involved in the ...
Barde, Y. A. +5 more
core +2 more sources
Ethylene Signal Transduction [PDF]
Annals of Botany, 2005 The phytohormone ethylene is a key regulator of plant growth and development. Components of the pathway for ethylene signal transduction were identified by genetic approaches in Arabidopsis and have now been shown to function in agronomically important plants as well.This review focuses on recent advances in our knowledge on ethylene signal ...
Chen, Yi-Feng +2 more
openaire +3 more sources
Oxygen Signal Transduction [PDF]
IUBMB Life, 2001 AbstractAlthough manifestations of O 2 adaptation have long been examined, only now are biochemical mechanisms of O 2 regulation beginning to be understood. This article comments on the current state of knowledge about proteins that function as direct sensors of molecular oxygen and makes predictions about as yet undiscovered sensors.
openaire +2 more sources
Extensive quantitative remodeling of the proteome between normal colon tissue and adenocarcinoma
Molecular Systems Biology, 2012 We report a proteomic analysis of microdissected material from formalin‐fixed and paraffin‐embedded colorectal cancer, quantifying >7500 proteins between patient matched normal mucosa, primary carcinoma, and nodal metastases.
Jacek R Wiśniewski +5 more
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Robust dimethyl‐based multiplex‐DIA doubles single‐cell proteome depth via a reference channel
Molecular Systems Biology, 2023 Single‐cell proteomics aims to characterize biological function and heterogeneity at the level of proteins in an unbiased manner. It is currently limited in proteomic depth, throughput, and robustness, which we address here by a streamlined multiplexed ...
Marvin Thielert +16 more
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