Bias signal control in differential protection [PDF]
MATEC Web of Conferences, 2018 The problem is to ensure the stability of the differential protection functioning at deep saturation of the cores of electromagnetic current transformers. The errors of current transformers support the greatest influence on the operation of differential protections.
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CPT: Pharmacometrics & Systems PharmacologyModel simplification is a process to simplify large‐scale mathematical models to enable easy applications such as simulation and parameter estimation.
Liang Yang +3 more
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Loss of biased signaling at a G protein-coupled receptor in overexpressed systems.
PLoS ONE, 2023 G protein-coupled receptors (GPCRs) regulate cellular signaling pathways by coupling to two classes of transducers: heterotrimeric G proteins and β-arrestins.
Angus Li +4 more
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Quinolones modulate ghrelin receptor signaling: potential for a novel small molecule scaffold in the treatment of cachexia [PDF]
, 2018 Cachexia is a metabolic wasting disorder characterized by progressive weight loss, muscle atrophy, fatigue, weakness, and appetite loss. Cachexia is associated with almost all major chronic illnesses including cancer, heart failure, obstructive ...
Cano, Rafael +8 more
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ClickArr: a novel, high-throughput assay for evaluating β-arrestin isoform recruitment
Frontiers in Pharmacology, 2023 Background: Modern methods for quantifying signaling bias at G protein–coupled receptors (GPCRs) rely on using a single β-arrestin isoform. However, it is increasingly appreciated that the two β-arrestin isoforms have unique roles, requiring the ability ...
Alexander R. French +6 more
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Isoprenoids determine Th1/Th2 fate in pathogenic T cells, providing a mechanism of modulation of autoimmunity by atorvastatin. [PDF]
, 2006 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase is a critical enzyme in the mevalonate pathway that regulates the biosynthesis of cholesterol as well as isoprenoids that mediate the membrane association of certain GTPases.
Dunn, Shannon E +6 more
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Loads bias genetic and signaling switches in synthetic and natural systems.
PLoS Computational Biology, 2014 Biological protein interactions networks such as signal transduction or gene transcription networks are often treated as modular, allowing motifs to be analyzed in isolation from the rest of the network.
Samanthe M Lyons +3 more
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Spatio-temporal regulation of concurrent developmental processes by generic signaling downstream of chemokine receptors [PDF]
, 2018 Chemokines are secreted proteins that regulate a range of processes in eukaryotic organisms. Interestingly, different chemokine receptors control distinct biological processes, and the same receptor can direct different cellular responses, but the basis ...
Malhotra, Divyanshu +3 more
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Correcting the minimization bias in searches for small signals [PDF]
Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment, 2003 We discuss a method for correcting the bias in the limits for small signals if those limits were found based on cuts that were chosen by minimizing a criterion such as sensitivity. Such a bias is commonly present when a "minimization" and an "evaluation" are done at the same time. We propose to use a variant of the bootstrap to adjust the limits.
Rolke, Wolfgang A., Lopez, Angel M.
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Counterclockwise rotation of the flagellum promotes biofilm initiation in Helicobacter pylori
mBioMotility promotes biofilm initiation during the early steps of this process: microbial surface association and attachment. Motility is controlled in part by chemotaxis signaling, so it seems reasonable that chemotaxis may also affect biofilm formation ...
Xiaolin Liu +4 more
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