Results 1 to 10 of about 2,656,427 (351)
Modelling cellular signalling systems [PDF]
Essays in Biochemistry, 2008 Cell signalling pathways and networks are complex and often non-linear. Signalling pathways can be represented as systems of biochemical reactions that can be modelled using differential equations. Computational modelling of cell signalling pathways is emerging as a tool that facilitates mechanistic understanding of complex biological systems ...
Padmini, Rangamani, Ravi, Iyengar
openaire +2 more sources
The LRRK2 signalling system [PDF]
Cell and Tissue Research, 2018 The LRRK2 gene is a major contributor to genetic risk for Parkinson's disease and understanding the biology of the leucine-rich repeat kinase 2 (LRRK2, the protein product of this gene) is an important goal in Parkinson's research. LRRK2 is a multi-domain, multi-activity enzyme and has been implicated in a wide range of signalling events within the ...
Price, Alice +3 more
openaire +2 more sources
Molecular Metabolism, 2014 Objective: Leptin responsive neurons play an important role in energy homeostasis, controlling specific autonomic, behavioral, and neuroendocrine functions.
Kavon Rezai-Zadeh +8 more
doaj +1 more source
Pulsatile Hormonal Signaling to Extracellular Signal-Regulated Kinase: Exploring System Sensitivity to Gonadotropin-Releasing Hormone Pulse Frequency and Width [PDF]
, 2014 Gonadotropin-releasing hormone (GnRH) is secreted in brief pulses that stimulate synthesis and secretion of pituitary gonadotropin hormones and thereby mediate control of reproduction.
Armstrong +41 more
core +2 more sources
Purinergic signalling in systemic sclerosis
Rheumatology, 2021 Abstract SSc is a chronic autoimmune rheumatic disease that involves numerous organs and presents major management challenges. The histopathologic hallmarks of SSc include vasculopathy, fibrosis and autoimmune phenomena involving both innate and adaptive immune systems.
Höppner, Jakob +6 more
openaire +2 more sources
Dissecting the dynamics of signaling events in the BMP, WNT, and NODAL cascade during self-organized fate patterning in human gastruloids. [PDF]
, 2019 During gastrulation, the pluripotent epiblast self-organizes into the 3 germ layers-endoderm, mesoderm and ectoderm, which eventually form the entire embryo.
Chhabra, Sapna +4 more
core +1 more source
The Many Hats of Sonic Hedgehog Signaling in Nervous System Development and Disease. [PDF]
, 2016 Sonic hedgehog (Shh) signaling occurs concurrently with the many processes that constitute nervous system development. Although Shh is mostly known for its proliferative and morphogenic action through its effects on neural stem cells and progenitors, it ...
Belgacem, Yesser H +4 more
core +2 more sources
Systems theory of Smad signalling [PDF]
IEE Proceedings - Systems Biology, 2006 Transforming Growth Factor-beta (TGF-beta) signalling is an important regulator of cellular growth and differentiation. The principal intracellular mediators of TGF-beta signalling are the Smad proteins, which upon TGF-beta stimulation accumulate in the nucleus and regulate transcription of target genes.
Clarke, D. C., Betterton, M. D., Liu, X.
openaire +3 more sources
Full-Bridge Diode-Clamped Four-Level Symmetric Switching Converter
IEEE Access, 2023 In this paper, we propose a novel full-bridge (FB) diode-clamped four-level symmetric switching converter. Multi-neighboring reference vector discontinuous PWM (MNRV DPWM) for FB topology was implemented using a symmetric half-bridge (HB)-based control ...
Min-Sup Song, Jaewon Kim, Jae-Bum Lee
doaj +1 more source
Single-cell-based system to monitor carrier driven cellular auxin homeostasis [PDF]
, 2013 Background: Abundance and distribution of the plant hormone auxin play important roles in plant development. Besides other metabolic processes, various auxin carriers control the cellular level of active auxin and, hence, are major regulators of cellular
Barbez, Elke +7 more
core +3 more sources