Results 91 to 100 of about 2,656,427 (351)

Trackside Resource Management Scheme Based on Integration of TACS and CBTC Systems

open access: yesChengshi guidao jiaotong yanjiu
[Objective] Traditional signaling systems manage trackside resources using routing-based methods and calculate movement authority accordingly. In contrast, the TACS (train autonomous circumnavigation system) manages resources from the perspective of ...
ZHANG Chong, CHEN Shaowen
doaj   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

open access: yesFEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai   +9 more
wiley   +1 more source

GNSS signals acquired by a Software Defined Radio (SDR) system subject to ionospheric scintillations

open access: green, 2023
Emanuele Pica   +4 more
openalex   +1 more source

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

open access: yesFEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes   +4 more
wiley   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

open access: yesFEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto   +3 more
wiley   +1 more source

Optimization of Interface Content between Shanghai Rail Transit Audio Video Unified Information Service System and Signaling System

open access: yesChengshi guidao jiaotong yanjiu
Objective To improve the real-time, accuracy, and efficiency of information services, and enhance the operational service efficiency and quality of Shanghai rail transit, it is essential to optimize the interface content between the audio video unified ...
DU Qijun
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

open access: yesFEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Solution to Shorten Track Usable Length at City Railway Turnout Stations by Using Continuation Routes

open access: yesChengshi guidao jiaotong yanjiu
[Objective]Compared to the CBTC (communication-based train control) system, CTCS2+ATO (Chinese train control system level 2 + automatic train operation) system requires longer usable track lengths due to its built-in protection zones, leading to ...
SONG Rui
doaj   +1 more source

Self-organization of signal transduction

open access: yes, 2013
We propose a model of parameter learning for signal transduction, where the objective function is defined by signal transmission efficiency. We apply this to learn kinetic rates as a form of evolutionary learning, and look for parameters which satisfy ...
Scheler, Gabriele
core   +2 more sources

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

open access: yesFEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura   +2 more
wiley   +1 more source

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