Results 111 to 120 of about 2,656,427 (351)
Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source
Analysis and Solution Schemes for Interference on Metro Signaling System Axle Counting Equipment
Chengshi guidao jiaotong yanjiu[Objective] During the system commissioning, train debugging and trial operation on Chengdu Metro Line 18, the axle counting equipment exhibits AIO (abnormal interference and occupation) due to various disturbances in different scenarios, significantly ...
Rongbing YANG +3 more
doaj +1 more source
Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source
Time Synchronization Scheme for Train FAO Signaling System
Chengshi guidao jiaotong yanjiu[Objective] Time synchronization is the foundation for ensuring the coordinated linkage of sub-systems within the signaling system, which directly affects the punctuality and operational safety of trains, serving as the basis for achieving train FAO ...
Qiguang HUANG, Yu LIANG
doaj +1 more source
Research on Data Platform of Urban Rail Signaling Intelligent Operation and Maintenance System
Kongzhi Yu Xinxi Jishu, 2021 Aiming at the problem of massive data processing in the construction and application of urban rail signaling intelligent operation and maintenance system, this paper studies a data platform of urban rail signaling intelligent operation and maintenance ...
DENG Yongqi, YANG Jiang, YANG Yibin
doaj
Biglycan : a multivalent proteoglycan providing structure and signals [PDF]
, 2013 Research over the past few years has provided fascinating results indicating that biglycan, besides being a ubiquitous structural component of the extracellular matrix (ECM), may act as a signaling molecule.
Năstase, Mădălina-Viviana +2 more
core
Molecular Oncology, EarlyView.The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués +3 more
wiley +1 more source
Research on Signaling System of City (Suburban) Railway Cross-line Operation to Intercity Railway
Chengshi guidao jiaotong yanjiuObjective City (suburban) railways are a weak link in the four-network integrated development of rail transit system in China. There is currently no unified understanding regarding their functional positioning and passenger flow demands.
Xiangfei DENG
doaj +1 more source
Molecular Oncology, EarlyView.We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck +12 more
wiley +1 more source
Chengshi guidao jiaotong yanjiu[Objective] The signaling system for Xi’an Metro Line 2 Phase Ⅰ project (hereinafter referred to as Line 2) utilizes an imported system, while Phase Ⅱ adopts a domestically developed system.
SUN Hui, REN Yaping, LIANG Bo
doaj +1 more source