Results 131 to 140 of about 2,656,427 (351)
DEVELOPMENT OF A M3S PROTOTYPE SYSTEM USING DIGITAL SIGNAL PROCESSOR [PDF]
, 2003 Jen-Chien Chien +5 more
openalex +1 more source
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
New-generation Signaling System Construction Scheme Based on Cloud Architecture
Chengshi guidao jiaotong yanjiu[Objective] With the theme of promoting urban rail transit information, developing intelligent system, and building 'smart urban rail' for a highly integrated urban rail transit cloud platform is the direction of technological development in the new era.
Minjie LIU, Gang WU
doaj +1 more source
Spatiotemporal regulation of the BarA/UvrY two-component signaling system. [PDF]
J Biol Chem, 2023 Contreras FU +5 more
europepmc +1 more source
Molecular Oncology, EarlyView.The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola +12 more
wiley +1 more source
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
Safety Evaluation of Urban Rail Transit Signal System Based on HAZOP and ALARP Principles
机车电传动, 2018 Safety requirements of subway signaling system in operating stage were analysed, the potential risks of evaluating and controlling the signal system based on HAZOP (Hazard and Operability Analysis) and ALARP (as Low as Reasonably Practicable) affecting ...
MO Zhigang, LUO Hanbin
doaj
Urban Rail Transit Signaling System Status Assessment Method Based on Analytic Hierarchy Process
Chengshi guidao jiaotong yanjiu[Objective] Shanghai rail transit signaling system faces challenges including large scale, complex model variations, and inconsistent operational lifespans.
WU Min, ZHANG Yu, CAO Yuan
doaj +1 more source