Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma
Molecular Oncology, EarlyView.Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken +7 more
wiley +1 more source
Research on Protection Section Setting of Urban Rail Transit Signaling System
Kongzhi Yu Xinxi Jishu, 2020 In urban rail transit, signaling system needs to set up overlap reasonably so as to meet the requirements of high speed route terminal train approaching, precise train stopping, and also to ensure driving safety.
ZHANG Datao
doaj
Single-Cell Measurements and Modeling and Computation of Decision-Making Errors in a Molecular Signaling System with Two Output Molecules. [PDF]
Biology (Basel), 2023 Emadi A +3 more
europepmc +1 more source
Generating radar signals using one-dimensional GAN-based model for target classification in radar systems [PDF]
, 2023 Taher Abdel-Fattah +3 more
openalex +1 more source
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
Multilimbed membrane guanylate cyclase signaling system, evolutionary ladder. [PDF]
Front Mol Neurosci, 2022 Duda T, Sharma RK.
europepmc +1 more source
Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition
Molecular Oncology, EarlyView.We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li +10 more
wiley +1 more source
Platform Screen Door Interface Solutions in Signaling System Upgrading and Renovation
Chengshi guidao jiaotong yanjiu［Objective］When urban rail transit signaling systems reach their lifespan end, the aging signaling equipment must be upgrade and renovated. The PSD (platform screen door) interface is a crucial part in signaling system upgrade.
LI Cong, WU Gang
doaj +1 more source
A molecular network map of orexin-orexin receptor signaling system. [PDF]
J Cell Commun Signal, 2023 Chatterjee O +9 more
europepmc +1 more source
The Accuracy of Cell-based Dynamic Traffic Assignment: Impact of Signal Control on System Optimality [PDF]
, 2017 Tarikul Islam +4 more
openalex +1 more source