Results 141 to 150 of about 1,649,371 (295)

Transmembrane signalling systems.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 1984
The three major strategies for transmembrane signalling at the plasma membrane level involve either second messengers, ion channels or receptor-mediated endocytosis. Two second-messenger types of transmembrane signalling systems have been analyzed: the adenylate cyclase and protein kinase C systems. Both are triggered by a variety of biological signals
openaire   +1 more source

Reduced vascular leakage correlates with breast carcinoma T regulatory cell infiltration but not with metastatic propensity

Molecular Oncology, EarlyView.
A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He, Chiara Testini, Neda Hekmati, Altea Bonello, Aglaia Schiza, Emmanuel Nwadozi, Mia Phillipson, Carina Strell, Michael Welsh   +8 more
wiley   +1 more source

A Phylogenetic Perspective on the Evolutionary Patterns of the Animal Interleukin-10 Signaling System. [PDF]

Genes (Basel)
Tang L, Zhou Z, Wang W, Li D, Hao T, Chen Y.   +5 more
europepmc   +1 more source

G protein-coupled estrogen receptor 1 regulates renal endothelin-1 signaling system in a sex-specific manner. [PDF]

Front Physiol, 2023
Guthrie GL, Almutlaq RN, Sugahara S, Butt MK, Brooks CR, Pollock DM, Gohar EY.   +6 more
europepmc   +1 more source

A Lipid Transfer Protein Signaling Axis Exerts Dual Control of Cell-Cycle and Membrane Trafficking Systems [PDF]

, 2018
Jin Huang, Carl J. Mousley, Louis Dacquay, Nairita Maitra, Guillaume Drin, Chong He, Neale D. Ridgway, Ashutosh Tripathi, Michael A. Kennedy, Brian K. Kennedy, Wenshe Ray Liu, Kristin Baetz, Michael Polymenis, Vytas A. Bankaitis   +13 more
openalex   +1 more source

Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting

Molecular Oncology, EarlyView.
CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia, Noelia Moares, Wenjie Yi‐He, Rosa Luna‐Espejo, Ricardo Fernandez‐Cisnal, Javier Ocaña‐Cuesta, Juan P. Muñoz‐Miranda, Antonio Gabucio, Cecilia M. Fernandez‐Ponce, Francisco Garcia‐Cozar   +9 more
wiley   +1 more source

Advances in the role of the IGF signaling system in myelodysplastic syndromes and acute myeloid leukemia. [PDF]

Front Oncol
Wang Y, Dong X, Tao S, Chen Q, Chen Y, Zhang L, Shi Y, He Z, Yu L, Wang C.   +9 more
europepmc   +1 more source

A Complete Endocannabinoid Signaling System Modulates Synaptic Transmission between Human Induced Pluripotent Stem Cell-Derived Neurons. [PDF]

Mol Pharmacol, 2023
Asher MJ, McMullan HM, Dong A, Li Y, Thayer SA.   +4 more
europepmc   +1 more source

Decision letter: Steroid hormone signaling activates thermal nociception during Drosophila peripheral nervous system development

, 2022

openalex   +1 more source

Improving PARP inhibitor efficacy in bladder cancer without genetic BRCAness by combination with PLX51107

Molecular Oncology, EarlyView.
Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz, Anna L. Bartkowiak, Michael Rose, Nora Kolks, Patrick Petzsch, Vandana Solanki, Anne Stoffel, Bianca Faßbender, Leandra Lepping, Julka Volkamer, Karl Köhrer, Marc Seifert, Tokameh Mahmoudi, Tahlita C. M. Zuiverloon, Günter Niegisch, Michèle J. Hoffmann   +15 more
wiley   +1 more source