Results 151 to 160 of about 1,649,371 (295)

The puzzling regulation of the interferon signaling system by the p53 tumor suppressor protein. [PDF]

Cell Mol Life Sci
Będzińska A, Łasut-Szyszka B, Krześniak M, Gdowicz-Kłosok A, Rusin M.   +4 more
europepmc   +1 more source

High-Level Expression of Cell-Surface Signaling System Hxu Enhances Pseudomonas aeruginosa Bloodstream Infection. [PDF]

Infect Immun, 2022
Yang F, Zhou Y, Chen P, Cai Z, Yue Z, Jin Y, Cheng Z, Wu W, Yang L, Ha UH, Bai F.   +10 more
europepmc   +1 more source

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

Discovery and functional characterization of a bombesin-type neuropeptide signaling system in an invertebrate. [PDF]

Proc Natl Acad Sci U S A
Huang W, Zhong X, Zampronio CG, Bottrill AR, Jones KGE, Tinoco AB, Guo L, Egertová M, Mirabeau O, Elphick MR.   +9 more
europepmc   +1 more source

Protein Tyrosine Phosphatases: A new paradigm in an old signaling system? [PDF]

Adv Cancer Res, 2021
Welsh CL, Pandey P, Ahuja LG.
europepmc   +1 more source

Estimation of Power System Stabilizer Parameters Using Swarm Intelligence Techniques to Improve Small Signal Stability of Power System

, 2017
Hossein Soleymani, Amin Hasanvand
openalex   +2 more sources

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

The Interplay Among HIV, LINE-1, and the Interferon Signaling System. [PDF]

Front Immunol, 2021
Zhao X, Zhao Y, Du J, Gao P, Zhao K.
europepmc   +1 more source

Further Strategies to Increase Engagement in an Online/Hybrid Signals and Systems Course [PDF]

Mary Lanzerotti, Scott Dunning, R. Michael Buehrer, A. Safaai‐Jazi, Nektaria Tryfona, Jianqiang Zhang, L. F. Lester, Kenneth Reid, Muhammad Dawood   +8 more
openalex   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source