STIM1-dependent peripheral coupling governs the contractility of vascular smooth muscle cells
eLife, 2022 Peripheral coupling between the sarcoplasmic reticulum (SR) and plasma membrane (PM) forms signaling complexes that regulate the membrane potential and contractility of vascular smooth muscle cells (VSMCs).
Vivek Krishnan +9 more
doaj +1 more source
Macroglobulin signaling system [PDF]
Biomeditsinskaya Khimiya, 2012 This review will focus on the systematization of knowledge about structure of macroglobulin signaling system, which includes macroglobulin family proteins (alpha-2-macroglobulin, alpha-2-glycoprotein, pregnancy associated plasma protein A), their receptors (LRP, grp78), ligands (proteinases, cytokines, hormones, lipids, et al.) transforming and ...
N A, Zorin, V N, Zorina
openaire +2 more sources
Transient Receptor Potential Channel Ankyrin 1: A Unique Regulator of Vascular Function
Cells, 2021 TRPA1 (transient receptor potential ankyrin 1), the lone member of the mammalian ankyrin TRP subfamily, is a Ca2+-permeable, non-selective cation channel.
Michael G. Alvarado +2 more
doaj +1 more source
Endothelial cell TRPA1 activity exacerbates cerebral hemorrhage during severe hypertension
Frontiers in Molecular Biosciences, 2023 Introduction: Hypoxia-induced dilation of cerebral arteries orchestrated by Ca2+-permeable transient receptor potential ankyrin 1 (TRPA1) cation channels on endothelial cells is neuroprotective during ischemic stroke, but it is unknown if the channel has
Michelle N. Sullivan +7 more
doaj +1 more source
Cell Reports, 2022 Summary: Biologically active small molecules can impart modulatory effects, in some cases providing extended long-term memory. In a screen of biologically active small molecules for regulators of tumor necrosis factor (TNF) induction, we identify several
Sinu P. John +13 more
doaj +1 more source
Performance Evaluation of Signaling in the IP QoS System
Journal of Telecommunications and Information Technology, 2023 The IP QoS System is based on next generation networks (NGN) and differentiated services (DiffServ) architectures. Its main part is a signaling system, which allows to send a request from a user to the system for establishing new connection with ...
Halina Tarasiuk +3 more
doaj +1 more source
Brain endothelial cell TRPA1 channels initiate neurovascular coupling
eLife, 2021 Cerebral blood flow is dynamically regulated by neurovascular coupling to meet the dynamic metabolic demands of the brain. We hypothesized that TRPA1 channels in capillary endothelial cells are stimulated by neuronal activity and instigate a propagating ...
Pratish Thakore +9 more
doaj +1 more source
Spatiomechanical Modulation of EphB4-Ephrin-B2 Signaling in Neural Stem Cell Differentiation. [PDF]
, 2018 Interactions between EphB4 receptor tyrosine kinases and their membrane-bound ephrin-B2 ligands on apposed cells play a regulatory role in neural stem cell differentiation.
Chung, Jean +6 more
core +2 more sources
Leptin modulates nutrient reward via inhibitory galanin action on orexin neurons
Molecular Metabolism, 2015 Objective: Leptin modulates food reward via central leptin receptor (LepRb) expressing neurons. Food reward requires stimulation of midbrain dopamine neurons and is modulated by central leptin action, but the exact central mechanisms remain unclear ...
Amanda Laque +10 more
doaj +1 more source
From data towards knowledge: Revealing the architecture of signaling systems by unifying knowledge mining and data mining of systematic perturbation data [PDF]
, 2013 Genetic and pharmacological perturbation experiments, such as deleting a gene and monitoring gene expression responses, are powerful tools for studying cellular signal transduction pathways.
Cowart, Ashley +3 more
core +3 more sources