Results 11 to 20 of about 1,649,371 (295)

Leptin receptor neurons in the dorsomedial hypothalamus are key regulators of energy expenditure and body weight, but not food intake

open access: yesMolecular Metabolism, 2014
Objective: Leptin responsive neurons play an important role in energy homeostasis, controlling specific autonomic, behavioral, and neuroendocrine functions.
Kavon Rezai-Zadeh   +8 more
doaj   +1 more source

Purinergic signalling in systemic sclerosis

open access: yesRheumatology, 2021
Abstract SSc is a chronic autoimmune rheumatic disease that involves numerous organs and presents major management challenges. The histopathologic hallmarks of SSc include vasculopathy, fibrosis and autoimmune phenomena involving both innate and adaptive immune systems.
Höppner, Jakob   +6 more
openaire   +2 more sources

Systems theory of Smad signalling [PDF]

open access: yesIEE Proceedings - Systems Biology, 2006
Transforming Growth Factor-beta (TGF-beta) signalling is an important regulator of cellular growth and differentiation. The principal intracellular mediators of TGF-beta signalling are the Smad proteins, which upon TGF-beta stimulation accumulate in the nucleus and regulate transcription of target genes.
Clarke, D. C., Betterton, M. D., Liu, X.
openaire   +3 more sources

Full-Bridge Diode-Clamped Four-Level Symmetric Switching Converter

open access: yesIEEE Access, 2023
In this paper, we propose a novel full-bridge (FB) diode-clamped four-level symmetric switching converter. Multi-neighboring reference vector discontinuous PWM (MNRV DPWM) for FB topology was implemented using a symmetric half-bridge (HB)-based control ...
Min-Sup Song, Jaewon Kim, Jae-Bum Lee
doaj   +1 more source

Content in Simple Signalling Systems [PDF]

open access: yesThe British Journal for the Philosophy of Science, 2018
Our understanding of communication and its evolution has advanced significantly through the study of simple models involving interacting senders and receivers of signals. Many theorists have thought that the resources of mathematical information theory are all that are needed to capture the meaning or content that is being communicated in these systems.
Shea, N, Godfrey-Smith, P, Cao, R
openaire   +5 more sources

Cold Signaling via the Two-Component Signaling System [PDF]

open access: yesMolecular Plant, 2013
Two-component signal transduction is commonly used as a stimulus–response coupling mechanism to allow organisms such as eubacteria, archea, and a few eukaryotes to sense and respond to changes in many different environmental conditions (Stock et al., 2000).
Kim, Jungmook, Jeon, Jin
openaire   +2 more sources

Three-Phase Diode-Clamped Four-Level PWM Inverter With Offset Voltage Injection

open access: yesIEEE Access
In this paper, a three-phase diode-clamped four-level PWM inverter with offset voltage injection is proposed. The proposed inverter is based on multi-neighboring reference vector (discontinuous) pulse-width modulation (MNRV (D)PWM), where multiple ...
Min-Sup Song, Jaewon Kim, Hwan-Hee Cho
doaj   +1 more source

Modularity in signaling systems [PDF]

open access: yesPhysical Biology, 2012
Modularity is a property by which the behavior of a system does not change upon interconnection. It is crucial for understanding the behavior of a complex system from the behavior of the composing subsystems. Whether modularity holds in biology is an intriguing and largely debated question.
openaire   +4 more sources

Bactericidal antibiotic treatment induces damaging inflammation via TLR9 sensing of bacterial DNA

open access: yesNature Communications
The immunologic consequences of using bactericidal versus bacteriostatic antibiotic treatments are unclear. We observed a bacteriostatic (growth halting) treatment was more protective than a bactericidal (bacteria killing) treatment in a murine ...
Julia L. Gross   +8 more
doaj   +1 more source

One-Leg Half-Bridge Diode-Clamped Four-Level PWM Inverter Based on MNRV PWM

open access: yesIEEE Access
This paper introduces a one-leg half-bridge (HB) diode-clamped four-level PWM inverter incorporating the multi-neighboring reference vector pulse-width modulation (MNRV PWM) methodology.
Min-Sup Song, Hyungchul Kim
doaj   +1 more source

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