Roles of estrogen receptor-alpha in mediating life span: the hypothalamic deregulation hypothesis. [PDF]
, 2017 In several species caloric restriction (CR) extends life span. In this paper we integrate data from studies on CR and other sources to articulate the hypothalamic deregulation hypothesis by which estrogen receptor-alpha (ER-α) signaling in the ...
Barakat, Rita +6 more
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Yersinia type III secretion : send in the effectors [PDF]
, 2002 Pathogenic Yersinia spp (Yersinia pestis, Yersinia pseudotuberculosis, and Yersinia enterocolitica) have evolved an exquisite method for delivering powerful effectors into cells of the host immune system where they inhibit signaling cascades and block ...
Cornelis, G. R.
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Content in Simple Signalling Systems [PDF]
The British Journal for the Philosophy of Science, 2018 Our understanding of communication and its evolution has advanced significantly through the study of simple models involving interacting senders and receivers of signals. Many theorists have thought that the resources of mathematical information theory are all that are needed to capture the meaning or content that is being communicated in these systems.
Shea, N, Godfrey-Smith, P, Cao, R
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The ubiquitin system and jasmonate signaling [PDF]
, 2016 The ubiquitin (Ub) system is involved in most, if not all, biological processes in eukaryotes. The major specificity determinants of this system are the E3 ligases, which bind and ubiquitinate specific sets of proteins and are thereby responsible for ...
Goossens, Alain +2 more
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Information transfer in signaling pathways : a study using coupled simulated and experimental data [PDF]
, 2008 Background: The topology of signaling cascades has been studied in quite some detail. However, how information is processed exactly is still relatively unknown.
Pahle, Jürgen +3 more
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Cold Signaling via the Two-Component Signaling System [PDF]
Molecular Plant, 2013 Two-component signal transduction is commonly used as a stimulus–response coupling mechanism to allow organisms such as eubacteria, archea, and a few eukaryotes to sense and respond to changes in many different environmental conditions (Stock et al., 2000).
Kim, Jungmook, Jeon, Jin
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Anosmin-1 modulates fibroblast growth factor receptor 1 signaling in human gonadotropin-releasing hormone olfactory neuroblasts through a heparan sulfate-dependent mechanism [PDF]
, 2004 Defects of either anosmin-1 or fibroblast growth factor receptor 1 (FGFR1) are known to underlie hereditary Kallmann's syndrome (KS), a human disorder of olfactory and gonadotropin-releasing hormone (GnRH) neuronal ontogeny.
Bouloux, PM +8 more
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Three-Phase Diode-Clamped Four-Level PWM Inverter With Offset Voltage Injection
IEEE AccessIn this paper, a three-phase diode-clamped four-level PWM inverter with offset voltage injection is proposed. The proposed inverter is based on multi-neighboring reference vector (discontinuous) pulse-width modulation (MNRV (D)PWM), where multiple ...
Min-Sup Song, Jaewon Kim, Hwan-Hee Cho
doaj +1 more source
Subverting sterols: rerouting an oxysterol-signaling pathway to promote tumor growth. [PDF]
, 2013 Oxysterols are oxidized derivatives of cholesterol that are generated enzymatically or through autoxidation. Initially identified as important lipid signaling molecules in the context of atherosclerosis and inflammation, accumulated evidence indicates ...
Bensinger, Steven J, York, Autumn G
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Modularity in signaling systems [PDF]
Physical Biology, 2012 Modularity is a property by which the behavior of a system does not change upon interconnection. It is crucial for understanding the behavior of a complex system from the behavior of the composing subsystems. Whether modularity holds in biology is an intriguing and largely debated question.
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