Results 81 to 90 of about 2,656,427 (351)

PICALM::MLLT10 translocated leukemia

open access: yesFEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen   +7 more
wiley   +1 more source

Research on A New CBTC Signaling System Based on Train-to-train Communication

open access: yes机车电传动, 2018
The new CBTC signaling system based on train-to-train communication (train-to-train signaling system) introduces the concept of train centered. Through the establishment of communication and cooperation between trains, the autonomous operation and ...
LI Lei, LIN Yunzhi, WANG Lili
doaj  

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

open access: yesFEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson   +7 more
wiley   +1 more source

Signaling System in Middle-low-speed Maglev Train

open access: yes机车电传动, 2011
This paper mainly introduced the signaling system, working principle and function of middle-low-speed maglev train. The signaling system design used an integrated idea, which had set automatic block, computer interlocking control and train control and ...
李文波
doaj  

Cybersecurity Situational Awareness System Applicable for Urban Rail Transit CBTC System

open access: yesChengshi guidao jiaotong yanjiu
Objective Urban rail transit CBTC (communication-based train control) systems face complex and diverse cybersecurity challenges. Existing cybersecurity tools feature high false alarm rates and poor adaptation to CBTC systems, lacking in-depth analysis of
LIU Dongdong   +5 more
doaj   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

open access: yesFEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee   +3 more
wiley   +1 more source

Scalable laws for stable network congestion control [PDF]

open access: yes, 2001
Discusses flow control in networks, in which sources control their rates based on feedback signals received from the network links, a feature present in current TCP protocols.
Doyle, John   +2 more
core   +1 more source

Structural biology of ferritin nanocages

open access: yesFEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

DEVELOPMENT OF STATE ARBITRATION BODIES IN KEMEROVO REGION IN THE 1950S – EARLY 1960S

open access: yesВестник Кемеровского государственного университета, 2014
The paper analyses the development of Kemerovo region state arbitration bodies in the 1950s and the early 1960s. The author exploits archive materials and investigates into the measures taken to improve the work of these bodies.
D. V. Voronin
doaj  

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