Results 1 to 10 of about 19,207 (136)

Sildenafil provokes headache but not migraine in men with migraine without aura: a randomized, placebo-controlled crossover trial [PDF]

The Journal of Headache and Pain
Background Cyclic guanosine monophosphate (cGMP)-mediated mechanisms plays a role in migraine pathophysiology. Sildenafil, a phosphodiesterase type 5 inhibitor, increases intracellular cGMP and can reliably induce migraine attacks in women.
Anas Mohammad, Ditte Bork Iversen, Nete Lundager Klokker Rausgaard, Christina Kruuse, Dagmar Beier, Tore Bjerregaard Stage, Lanfranco Pellesi   +6 more
doaj   +2 more sources

Preparation and physicochemical characterization of sildenafil cocrystals

Journal of Advanced Pharmaceutical Technology & Research, 2021
Sildenafil is a specific inhibitor of the phosphodiesterase type 5 (PDE-5) enzyme that protects cyclic guanosine monophosphate from breakdown by PDE-5. It is a biopharmaceutical categorization system Class II medication with low bioavailability because ...
Somchai Sawatdee, Apichart Atipairin, Supitchaya Rakkummerd, Onsinee Suriyaphol, David J Harding, Poowadon Muenraya, Phimphaka Harding   +6 more
doaj   +1 more source

Population pharmacokinetic analysis of sildenafil in term and preterm infants with pulmonary arterial hypertension

Scientific Reports, 2022
Sildenafil is widely used off-label in pediatric patients with pulmonary arterial hypertension (PAH). This study was conducted to characterize the pharmacokinetics (PK) of sildenafil in term and preterm neonates with PAH, by developing a population PK ...
Su-jin Rhee, Seung Han Shin, Jaeseong Oh, Young Hwa Jung, Chang Won Choi, Han-Suk Kim, Kyung-Sang Yu   +6 more
doaj   +1 more source

Oral Bioavailability and Pharmacokinetics of Sildenafil Orally Disintegrating Tablets under Various Gastric pH Levels Following Administration of Omeprazole in Rats

Life, 2023
Sildenafil citrate, an oral drug used to treat erectile dysfunction, has low water solubility and oral bioavailability. The solubility is greatly influenced by the pH, changing from 37.25 mg/mL to 0.22 mg/mL with a change in pH from 1.2 to 8.0.
Chin-Yu Shih, Chao-Yi Chen, Hsien-Te Lin, Ying-Ju Liao, Yao-Jen Liang   +4 more
doaj   +1 more source

Identification, synthesis, and characterization of potential genotoxic impurities of sildenafil citrate drug substance

Future Journal of Pharmaceutical Sciences, 2020
Background Sildenafil is a selective inhibitor of cyclic guanosine monophosphate (cGMP)-specifil phophodiesterase type 5 (PDE5). Sildenafil enhances the effect of nitric oxide by inhibiting phosphodiesterase type 5, which is responsible for the ...
P. Rajesh Reddy, Sivanadh Musunuri, D. Rama Sekhara Reddy, V. Subrahmanyam Chittala, V. N. S. Murthy P, K. Krishnamohan   +5 more
doaj   +1 more source

Development of a Sildenafil Citrate Microemulsion-Loaded Hydrogel as a Potential System for Drug Delivery to the Penis and Its Cellular Metabolic Mechanism

Pharmaceutics, 2020
Sildenafil citrate is used to treat mild to moderate erectile dysfunction and premature ejaculation. However, it has low oral bioavailability, numerous adverse effects, and delayed onset of action.
Apichart Atipairin, Charisopon Chunhachaichana, Titpawan Nakpheng, Narumon Changsan, Teerapol Srichana, Somchai Sawatdee   +5 more
doaj   +1 more source

Evaluation of cardiac injury biomarkers in serum following concomitant administration of sildenafil citrate with dextromethorphan and chlorpheniramine in rat [PDF]

Āsīb/shināsī-i Darmāngāhī-i Dāmpizishkī, 2021
Sildenafil citrate is an inhibitor of the enzyme phosphodiesterase 5, dextromethorphan is an antitussive with weak opioid effects, and chlorpheniramine is a first-generation antihistamine.
Rasol Sadeghy, B. Amouoghli Tabrizi, majid fartashvand   +2 more
doaj   +1 more source

HPLC-MS/MS Method for Quantitation of Sildenafil and Its Active Metabolite in Human Plasma

Регуляторные исследования и экспертиза лекарственных средств, 2020
A high demand for sildenafil-based drugs puts a premium on the development of methods for quantitation of sildenafil in bio-substrates to facilitate pharmacokinetic analysis in bioequivalence studies.
G. G. Rodionov, I. I. Shantyr, I. E. Ushal, E. V. Svetkina, E. A. Kolobova, K. A. Zakharov   +5 more
doaj   +1 more source

Effect of Maternal Sildenafil Supplementation During Gestation on the Reproductive Performance of Sows/Gilts and Growth Performance of Neonatal Piglets

Frontiers in Veterinary Science, 2022
Sildenafil, a phosphodiesterase 5 (PDE-5) inhibitor, provides an alternative and effective strategy to increase uterine blood flow and vascular development, thus improving fetal development.
Yue Wang, Yusheng Qin, Wei Zhao, Fusheng Yao, Wenjing Wang, Xiao Hu, Linghua Cheng, Lei An, Jianhui Tian   +8 more
doaj   +1 more source

Central retinal vein and artery occlusion associated with sildenafil: a case report and review of the literature

Journal of Medical Case Reports, 2023
Background Sildenafil is a selective phosphodiesterase type 5 inhibitor used for the treatment of erectile dysfunction and pulmonary hypertension. It is available over the counter in many countries. While there have been a few reports of retinal vascular
Ali Torkashvand, Pasha Anvari, Siavash Ketabi, Esmaeil Asadi Khameneh   +3 more
doaj   +1 more source