Results 11 to 20 of about 42,464 (273)

A Retrospective Study of Sildenafil Administration in 55 Cats with Cardiopulmonary Disease (2009–2021) [PDF]

Animals
Sildenafil is a drug used to successfully manage a variety of cardiopulmonary disorders in people and dogs, but there is limited information on its use in cats.
Jasmine Huynh, Samantha Dolan, Emily T. Karlin, Lisa M. Freeman, Elizabeth A. Rozanski, John E. Rush   +5 more
doaj   +2 more sources

Early Development of Sildenafil for Pulmonary Hypertension: A Retrospective Account. [PDF]

Pulm Circ
Butrous G.
europepmc   +3 more sources

Dapagliflozin, sildenafil and their combination in monocrotaline-induced pulmonary arterial hypertension

BMC Pulmonary Medicine, 2022
Background Dapagliflozin, a selective inhibitor of sodium-glucose cotransporter 2 (SGLT2), can reduce cardiovascular events and mortality in patients with heart failure. A number of mechanisms have been proposed to explain the beneficial effects of SGLT2
Yi Tang, Siyuan Tan, Minqi Li, Yi Tang, Xiaoping Xu, Qinghai Zhang, Qinghua Fu, Mingxiang Tang, Jin He, Yi Zhang, Zhaofen Zheng, Jian-qiang Peng, T. Zhu, Wenlin Xie   +13 more
semanticscholar   +1 more source

Population pharmacokinetic analysis of sildenafil in term and preterm infants with pulmonary arterial hypertension

Scientific Reports, 2022
Sildenafil is widely used off-label in pediatric patients with pulmonary arterial hypertension (PAH). This study was conducted to characterize the pharmacokinetics (PK) of sildenafil in term and preterm neonates with PAH, by developing a population PK ...
Su-jin Rhee, Seung Han Shin, Jaeseong Oh, Young Hwa Jung, Chang Won Choi, Han-Suk Kim, Kyung-Sang Yu   +6 more
doaj   +1 more source

Oral Bioavailability and Pharmacokinetics of Sildenafil Orally Disintegrating Tablets under Various Gastric pH Levels Following Administration of Omeprazole in Rats

Life, 2023
Sildenafil citrate, an oral drug used to treat erectile dysfunction, has low water solubility and oral bioavailability. The solubility is greatly influenced by the pH, changing from 37.25 mg/mL to 0.22 mg/mL with a change in pH from 1.2 to 8.0.
Chin-Yu Shih, Chao-Yi Chen, Hsien-Te Lin, Ying-Ju Liao, Yao-Jen Liang   +4 more
doaj   +1 more source

Visual Side Effects Linked to Sildenafil Consumption: An Update

Biomedicines, 2021
Phosphodiesterase type 5 (PDE5) inhibitors such as Viagra® (sildenafil citrate) have demonstrated efficacy in the treatment of erectile dysfunction (ED) by inducing cyclic guanosine monophosphate (cGMP) elevation followed by vasodilation and increased ...
Eva Ausó, V. Gómez-Vicente, Gema Esquiva   +2 more
semanticscholar   +1 more source

The Potential Role of Sildenafil in Cancer Management through EPR Augmentation

Journal of Personalized Medicine, 2021
Enhanced permeation retention (EPR) was a significant milestone discovery by Maeda et al. paving the path for the emerging field of nanomedicine to become a powerful tool in the fight against cancer.
M. Haider, A. Elsherbeny, V. Pittalà, A. N. Fallica, M. A. Alghamdi, K. Greish   +5 more
semanticscholar   +1 more source

Identification, synthesis, and characterization of potential genotoxic impurities of sildenafil citrate drug substance

Future Journal of Pharmaceutical Sciences, 2020
Background Sildenafil is a selective inhibitor of cyclic guanosine monophosphate (cGMP)-specifil phophodiesterase type 5 (PDE5). Sildenafil enhances the effect of nitric oxide by inhibiting phosphodiesterase type 5, which is responsible for the ...
P. Rajesh Reddy, Sivanadh Musunuri, D. Rama Sekhara Reddy, V. Subrahmanyam Chittala, V. N. S. Murthy P, K. Krishnamohan   +5 more
doaj   +1 more source

Portopulmonary hypertension practice patterns after liver transplantation

Liver Transplantation, EarlyView., 2022
Abstract Portopulmonary hypertension (POPH) is a type of pulmonary arterial hypertension occurring exclusively in those with portal hypertensive liver disease. Liver transplantation (LT) can significantly improve outcomes. Current guidelines counsel against immediate adjustments to targeted therapy after LT and suggest routine echocardiography as ...
Arun Jose, Elizabeth J. Kopras, Shimul A. Shah, Jean M. Elwing   +3 more
wiley   +1 more source

Development of a Sildenafil Citrate Microemulsion-Loaded Hydrogel as a Potential System for Drug Delivery to the Penis and Its Cellular Metabolic Mechanism

Pharmaceutics, 2020
Sildenafil citrate is used to treat mild to moderate erectile dysfunction and premature ejaculation. However, it has low oral bioavailability, numerous adverse effects, and delayed onset of action.
Apichart Atipairin, Charisopon Chunhachaichana, Titpawan Nakpheng, Narumon Changsan, Teerapol Srichana, Somchai Sawatdee   +5 more
doaj   +1 more source