Results 31 to 40 of about 42,824 (215)
Journal of Advanced Research, 2018 Sildenafil enhances the nitric oxide–cGMP pathway of erection, which is claimed to have a role in nocturnal penile tumescence and rigidity (NPTR). This study aimed to find whether RigiScan can predict the response to sildenafil among erectile dysfunction
Samir M. Elhanbly +3 more
doaj +1 more source
5-Hydroxy-3-(4-hydroxyphenyl)-8,8-dimethyl-6- (3-methylbut-2-enyl)pyrano[2,3-h]chromen-4-one [PDF]
, 2018 Natural and semi-synthetic compounds are being studied as novel phosphodiesterase 5 (PDE5) inhibitors for the treatment of erectile dysfunction, pulmonary hypertension, and lower urinary symptoms.
Ongaro, Alberto +2 more
core +1 more source
Sildenafil helps the beat go on. [PDF]
Exp PhysiolExperimental Physiology, Volume 111, Issue 3, Page 596-597, 1 March 2026.
Hancox JC.
europepmc +2 more sources
The Egyptian Heart Journal, 2014 Objectives: To test the safety of sildenafil in patients with stable coronary artery disease (CAD). Methods: Sixty-one patients with stable CAD, documented by coronary angiography were included in this phase I study.
Mohamed Salem +4 more
doaj +1 more source
Tadalafil improves lean mass and endothelial function in nonobese men with mild ED/LUTS: in vivo and in vitro characterization [PDF]
, 2017 PURPOSE: Phosphodiesterase type-5 inhibitor administration in diabetic men with erectile dysfunction (ED) is associated with reduced waist circumference.
Aversa, Antonio +8 more
core +1 more source
PLoS ONE, 2015 BackgroundMitochondrial large-conductance Ca2+-sensitive potassium (mBKCa) channels are involved in myocardial ischemic preconditioning. Their role in sildenafil-induced cardioprotection is unknown.
Friederike Behmenburg +6 more
doaj +1 more source
Sildenafil reduces insulin-resistance in human endothelial cells. [PDF]
PLoS ONE, 2011 BACKGROUND: The efficacy of Phosphodiesterase 5 (PDE5) inhibitors to re-establish endothelial function is reduced in diabetic patients. Recent evidences suggest that therapy with PDE5 inhibitors, i.e.
Caterina Mammi +15 more
doaj +1 more source
Phenotyping of Fontan-Associated Renal Physiology and Disease. [PDF]
Compr PhysiolIn patients with a Fontan circulation, both kidney function and glomerular injury progressively decline with age, with a stronger decline than in healthy individuals. Additionally, intrarenal haemodynamics in patients with a Fontan circulation demonstrate decreased venous and arterial compliance, evident through elevated venous impedance and renal ...
van Hassel G +7 more
europepmc +2 more sources
The role of endothelin-1 in pulmonary arterial hypertension. [PDF]
, 2014 Pulmonary arterial hypertension (PAH) is a rare but debilitating disease, which if left untreated rapidly progresses to right ventricular failure and eventually death. In the quest to understand the pathogenesis of this disease differences in the profile,
Chester, AH, Yacoub, MH
core +1 more source
Effect of sildenafil added to antifibrotic treatment in idiopathic pulmonary fibrosis
Scientific Reports, 2021 Sildenafil is a phosphodiesterase-5 inhibitor used to treat idiopathic pulmonary arterial hypertension; however, its benefits are unclear in patients with advanced idiopathic pulmonary fibrosis (IPF).
Jieun Kang, Jin Woo Song
doaj +1 more source