Results 41 to 50 of about 42,464 (273)

Nocturnal penile erections: A retrospective study of the role of RigiScan in predicting the response to sildenafil in erectile dysfunction patients

Journal of Advanced Research, 2018
Sildenafil enhances the nitric oxide–cGMP pathway of erection, which is claimed to have a role in nocturnal penile tumescence and rigidity (NPTR). This study aimed to find whether RigiScan can predict the response to sildenafil among erectile dysfunction
Samir M. Elhanbly, Mamdouh M. Abdel-gawad, Ayman A. Elkholy, Ahmed F. State   +3 more
doaj   +1 more source

Sildenafil for improving outcomes in patients with corrected valvular heart disease and persistent pulmonary hypertension: a multicenter, double-blind, randomized clinical trial

European Heart Journal, 2017
Aims We aimed to determine whether treatment with sildenafil improves outcomes of patients with persistent pulmonary hypertension (PH) after correction of valvular heart disease (VHD).
Javier Bermejo, R. Yotti, R. García-Orta, P. L. Sánchez‐Fernández, Mario Castaño, J. Segovia-Cubero, P. Escribano-Subías, J. S. San Román, Xavier Borrás, Angel Alonso‐Gómez, J. Botas, M. Crespo-Leiro, Sonia Velasco, A. Bayés-Genís, A. López, R. Muñoz-Aguilera, E. de Teresa, J. González-Juanatey, Arturo Evangelista, T. Mombiela, A. González-Mansilla, J. Elízaga, Javier Martín-Moreiras, J. González-Santos, E. Moreno-Escobar, F. Fernández‐Avilés, Javier Raquel Teresa Ana Jaime José A Esther Candelas Ric Bermejo Yotti Mombiela Gónzález-Mansilla Elízaga G, Javier Bermejo, R. Yotti, T. Mombiela, A. González-Mansilla, J. Elízaga, J. García-Robles, E. Pérez-David, Candelas Pérez del Villar, R. Sanz, Enrique Gutiérrez-Ibañes, M. Vázquez, A. Mur, Y. Benito, P. Martínez‐Legazpi, A. Barrio, A. Vázquez, R. García-Orta, Inés Uribe, M. González, Pedro Luis Sánchez, J. González-Santos, Javier Martín-Moreiras, A. Arribas, M. M. Clemente Lorenzo, Alejandro Diego Nieto, Mario Castaño, A. Pérez de Prado, D. Alonso, J. Segovia-Cubero, M. Gómez-Bueno, I. Sayago Silva, M. Ángel Cavero, P. Escribano-Subías, L. Dominguez, R. Tello de Meneses, M. R. Ruiz Cano, C. Jimenez Lopez-Guarch, J. S. San Román, P. Mota, Xavier Borrás, C. Amorós Galitó, Angel Alonso‐Gómez, M. C. Bello Mora, D. Mesa Rubio, J. Botas, R. Campuzano, M. Crespo-Leiro, R. Marzoa, J. Cuenca, Sonia Velasco, R. Muñoz, V. Suberviola, C. Beltrán Herrera, L. Mora, M. Mar Sarrión, D. Vaqueriza, A. Bayés-Genís, E. Ferrer, J. González-Juanatey, B. Cid, A. M. Monzonís, A. López, J. M. F. Arizón de Prado, M. Santisteban, Arturo Evangelista, D. Garcia-Dorado, E. de Teresa, M. Jiménez-Navarro, Fernando Carrasco Chinchilla, E. Moreno-Escobar, J. Alonso   +97 more
semanticscholar   +1 more source

Impact of Mitochondrial Ca2+-Sensitive Potassium (mBKCa) Channels in Sildenafil-Induced Cardioprotection in Rats.

PLoS ONE, 2015
BackgroundMitochondrial large-conductance Ca2+-sensitive potassium (mBKCa) channels are involved in myocardial ischemic preconditioning. Their role in sildenafil-induced cardioprotection is unknown.
Friederike Behmenburg, Marianne Dorsch, Ragnar Huhn, David Mally, André Heinen, Markus W Hollmann, Marc M Berger   +6 more
doaj   +1 more source

The effect of sesame intake on adult albino rat testis during sildenafil long-term administration

Journal of Basic and Applied Zoology, 2021
Background Sildenafil (Viagra) is widely used for the treatment of erectile dysfunction under various etiologies. Unfortunately, chronic administration of sildenafil negatively affects fertility.
M. Goweder Fawzia, T. M. Abu El-Nasr, A. A. El-Sayed   +2 more
doaj   +1 more source

Sildenafil reduces insulin-resistance in human endothelial cells. [PDF]

PLoS ONE, 2011
BACKGROUND: The efficacy of Phosphodiesterase 5 (PDE5) inhibitors to re-establish endothelial function is reduced in diabetic patients. Recent evidences suggest that therapy with PDE5 inhibitors, i.e.
Caterina Mammi, Donatella Pastore, Marco F Lombardo, Francesca Ferrelli, Massimiliano Caprio, Claudia Consoli, Manfredi Tesauro, Lucia Gatta, Massimo Fini, Massimo Federici, Paolo Sbraccia, Giulia Donadel, Alfonso Bellia, Giuseppe M Rosano, Andrea Fabbri, Davide Lauro   +15 more
doaj   +1 more source

Prenatal Sildenafil and Fetal-placental Programming in Human Pregnancies Complicated by Fetal Growth Restriction: A Retrospective Gene Expression Analysis

Journal of Trial and Error, 2023
Objective: Fetal growth restricted (FGR) offspring are more susceptible to develop cardiovascular and renal disease. The potential therapeutic value of sildenafil to improve fetal growth has recently been evaluated in several randomized clinical trials ...
Fieke Terstappen, Torsten Plösch, Jorg J.A. Calis, Wessel Ganzevoort, Anouk Pels, Nina D. Paauw, Sanne J. Gordijn, Bas B. van Rijn, Michal Mokry, A. Titia Lely   +9 more
doaj   +1 more source

Short-term effects of sildenafil in the treatment of dogs with pulmonary hypertension secondary to degenerative mitral valve disease [PDF]

Veterinary World, 2020
Background and Aim: Pulmonary hypertension (PH) is a common complication of degenerative mitral valve disease (DMVD). Sildenafil, a phosphodiesterase-5 inhibitor, has effects in reducing pulmonary arterial pressure by selectively dilating pulmonary ...
Karun Saetang, Sirilak Disatian Surachetpong   +1 more
doaj   +1 more source

Resposta pressórica de pacientes com miocardiopatia chagásica ante o uso do sildenafil Pressure response in chagasic cardiomyopathy patients after using sildenafil

Arquivos Brasileiros de Cardiologia, 2007
OBJETIVO: Verificar o efeito do sildenafil na pressão arterial (PA) e freqüência cardíaca (FC) de indivíduos portadores de miocardiopata chagásica (MCC) e de disfunção ventricular sistólica grave ...
Rodrigo Abensur Athanazio, Daniel Meira Freitas, Daniela Batista de Almeida, Nei Dantas, Francisco Reis   +4 more
doaj   +1 more source

Nintedanib and Sildenafil in Patients with Idiopathic Pulmonary Fibrosis and Right Heart Dysfunction. A Prespecified Subgroup Analysis of a Double-Blind Randomized Clinical Trial (INSTAGE)

American Journal of Respiratory and Critical Care Medicine, 2019
Rationale: In the INSTAGE trial in patients with idiopathic pulmonary fibrosis (IPF) and severely impaired gas exchange, nintedanib plus sildenafil was associated with numerical benefits on St. George’s Respiratory Questionnaire (SGRQ) total score, brain
J. Behr, M. Kolb, J. Song, F. Luppi, B. Schinzel, S. Stowasser, M. Quaresma, F. Martinez   +7 more
semanticscholar   +1 more source

Accelerating Primary Screening of USP8 Inhibitors from Drug Repurposing Databases with Tree‐Based Machine Learning

Advanced Intelligent Discovery, EarlyView.
This study introduces a tree‐based machine learning approach to accelerate USP8 inhibitor discovery. The best‐performing model identified 100 high‐confidence repurposable compounds, half already approved or in clinical trials, and uncovered novel scaffolds not previously studied. These findings offer a solid foundation for rapid experimental follow‐up,
Yik Kwong Ng, Sharon Ai Er Lam, Wei Chun Lim, Hannah Hui Min Toh, Shi Jun Ang   +4 more
wiley   +1 more source