Results 61 to 70 of about 42,824 (215)

Endothelial dysfunction markers as a therapeutic target for Sildenafil treatment and effects on metabolic control in type 2 diabetes [PDF]

, 2015
Endothelial dysfunction (ED) plays a role in diabetic cardiovascular complications. Hyperglycemia increases cytockines involved in vascular inflammation.
Bertolini, Camilla, Fallarino, Mara, Filardi, Tiziana, Gianfrilli, Daniele, Giannetta, Elisa, Lenti, Luisa, Lenzi, Andrea, Lococo, Manuela, Mandosi, Elisabetta, Morano, Susanna, Venneri, MARY ANNA   +10 more
core   +1 more source

Interventional therapies for chronic heart failure: An overview of recent developments

ESC Heart Failure, Volume 12, Issue 2, Page 1081-1094, April 2025.
Abstract Heart failure (HF), the final manifestation of most cardiovascular diseases, has become a major global health concern, affecting millions of individuals. Despite basic drug treatments, patients present with high morbidity and mortality rates. However, recent advancements in interventional therapy have shown promising results in improving the ...
Bingchen Guo, Si Shi, Yutong Guo, Jie Xiong, Bo Wang, Zengxiang Dong, Dianyu Gao, Yingfeng Tu   +7 more
wiley   +1 more source

Nitric oxide regulates skeletal muscle fatigue, fiber type, microtubule organization, and mitochondrial ATP synthesis efficiency through cGMP-dependent mechanisms [PDF]

, 2016
Aim: Skeletal muscle nitric oxide–cyclic guanosine monophosphate (NO-cGMP) pathways are impaired in Duchenne and Becker muscular dystrophy partly because of reduced nNOSμ and soluble guanylate cyclase (GC) activity.
Balke, Jordan E, Brouckaert, Peter, Buys, Emmanuel S, Knowels, Gary, Madorma, Derik, Marcinek, David J, Moon, Younghye, Percival, Justin M, Siegel, Michael P   +8 more
core   +1 more source

Cilostazol in patients with heart failure and preserved ejection fraction—The CLIP‐HFpEF trial

ESC Heart Failure, Volume 12, Issue 2, Page 1437-1446, April 2025.
• Cilostazol is an oral PDE‐3 inhibitor that may have advantageous effects in heart failure with preserved ejection fraction (HFpEF). • Cilostazol significantly improved short‐term heart failure‐related health status scores (KCCQ‐12) and NT‐proBNP levels when compared to placebo.
Norman Aiad, Jeanne du Fay de Lavallaz, Michael J. Zhang, Thanat Chaikijurajai, Bo Ye, Prabhjot S. Nijjar, Julie A. Lahiri, Cindy M. Martin, Tamas Alexy, Markus Meyer   +9 more
wiley   +1 more source

Effect of sildenafil in cavernous arteries of patients with erectile dysfunction

International Brazilian Journal of Urology, 2003
INTRODUCTION: Sildenafil citrate is a type 5 phosphodiesterase inhibitor, which has demonstrated excellent results in the treatment of erectile dysfunction.
Joaquim A Claro, Sérgio F Ximenes, Archimedes Nardozza Jr, Enrico Andrade, Leonardo Messina, Miguel Srougi   +5 more
doaj   +1 more source

Preoperative subcutaneous sildenafil injection increases random flap survival in rats [PDF]

Acta Cirúrgica Brasileira, 2018
Purpose: To investigate the effect of subcutaneous sildenafil on random flap survival. Methods: Fourteen Wistar rats, which were divided in to two groups, were used for this experimental study.
Merdan Serin, Dincer Altinel, Cem Leblebici, Burcu Biltekin, Mert Celikten, Fatih Irmak, Sevgi Kurt Yazar   +6 more
doaj   +2 more sources

Prenatal Sildenafil and Fetal-placental Programming in Human Pregnancies Complicated by Fetal Growth Restriction: A Retrospective Gene Expression Analysis

Journal of Trial and Error, 2023
Objective: Fetal growth restricted (FGR) offspring are more susceptible to develop cardiovascular and renal disease. The potential therapeutic value of sildenafil to improve fetal growth has recently been evaluated in several randomized clinical trials ...
Fieke Terstappen, Torsten Plösch, Jorg J.A. Calis, Wessel Ganzevoort, Anouk Pels, Nina D. Paauw, Sanne J. Gordijn, Bas B. van Rijn, Michal Mokry, A. Titia Lely   +9 more
doaj   +1 more source

Sildenafil promotes osteogenic differentiation of human mesenchymal stem cells and inhibits bone loss by affecting the TGF-β signaling pathway

Stem Cell Research & Therapy
Background Osteoporosis, a common bone disorder, is primarily managed pharmacologically. However, existing medications are associated with non-trivial side-effects.
Menglong Hu, Likun Wu, Erfan Wei, Xingtong Pan, Qiyue Zhu, Xv Xiuyun, Letian Lv, Xinyi Dong, Hao Liu, Yunsong Liu   +9 more
doaj   +1 more source

Current practices in the use of sildenafil for pulmonary arterial hypertension in Brazilian hospitals

BMC Research Notes, 2009
Background Sildenafil is a cyclic guanosine monophosphate-specific phosphodiesterase-5 inhibitor used for treating pulmonary hypertension. Although the use of sildenafil in patients under 18 years old is off-label, this inhibitor has been widely ...
Cabral Lucio M, de Souza Ana HA, Huf Gisele   +2 more
doaj   +1 more source

The situational Samaritan: How group reputation threat shapes reparatory behavior

Journal of Consumer Psychology, EarlyView.
Abstract Consumers often act to correct the wrongdoings of people close to them, such as family members or friends. The current research demonstrates that consumers may also engage in a variety of reparatory behaviors—from a simple apology to gift‐giving and tipping—to counter the misdeeds of in‐group strangers when their behavior threatens the ...
Julia Von Schuckmann, Lucia S. G. Barros, Grant E. Donnelly, Marco Bertini   +3 more
wiley   +1 more source