Results 21 to 30 of about 3,518 (133)

Astragaloside IV alleviates hypoxic pulmonary hypertension by inhibiting RELM‐β to reduce PINK1/Parkin‐mediated mitophagy in pulmonary artery smooth muscle cells (PASMCs)

British Journal of Pharmacology, Volume 182, Issue 24, Page 5933-5952, December 2025.
Background and Purpose Hypoxic pulmonary hypertension (HPH) is a chronic disorder marked by irreversible pulmonary vascular remodelling (PVR) and pulmonary artery smooth muscle cell (PASMC) dysfunction. Astragaloside IV (AS‐IV), a natural saponin from Astragalus, shows potential in HPH management. This study explores AS‐IV's protective effect on PVR in
Rongzhen Ding, Haiping Xie, Shuliu Sang, Li Qin, Yinhui Sun, Chao Zhang, Jian Yi, Hui Liu, Jianmin Fan, Guoran Peng, BeiBei Cheng, Lan Song, Aiguo Dai   +12 more
wiley   +1 more source

The Concise Guide to PHARMACOLOGY 2025/26: Enzymes

British Journal of Pharmacology, Volume 182, Issue S1, Page S307-S403, December 2025.
The Concise Guide to Pharmacology 2025/26 marks the seventh edition in this series of biennial publications in the British Journal of Pharmacology. Presented in landscape format, the guide provides a comparative overview of the pharmacology of drug target families. The concise nature of the Concise Guide refers to the style of presentation, being clear,
Stephen P. H. Alexander, Doriano Fabbro, Alasdair J. Gibb, Eamonn Kelly, Alistair A. Mathie, Chloe J. Peach, Emma L. Veale, Jane F. Armstrong, Elena Faccenda, Simon D. Harding, Christopher Southan, Jamie A. Davies, Stephanie Annett, Detlev Boison, Kathryn Elisa Burns, Carmen Dessauer, Jürg Gertsch, Nuala Ann Helsby, Angelo A. Izzo, Rennolds Ostrom, Ester Pagano, Andreas Papapetropoulos, Nigel J. Pyne, Susan Pyne, Tracy Robson, Roland Seifert, Johannes‐Peter Stasch, Csaba Szabo, Mario van der Stelt, Albert van der Vliet, Val Watts, Szu Shen Wong   +31 more
wiley   +1 more source

Sildenafil citrate: current clinical experience [PDF]

International Journal of Impotence Research, 2000
There is little question as to the efficacy of sildenafil citrate (Viagra) for the treatment of erectile dysfunction. Two years of post-marketing experience provide data which indicates that the efficacy and safety of sildenafil citrate is consistent with the data obtained in clinical trials.
openaire   +2 more sources

The Concise Guide to PHARMACOLOGY 2025/26: Transporters

British Journal of Pharmacology, Volume 182, Issue S1, Page S404-S496, December 2025.
The Concise Guide to Pharmacology 2025/26 marks the seventh edition in this series of biennial publications in the British Journal of Pharmacology. Presented in landscape format, the guide provides a comparative overview of the pharmacology of drug target families. The concise nature of the Concise Guide refers to the style of presentation, being clear,
Stephen P. H. Alexander, Alasdair J. Gibb, Eamonn Kelly, Alistair A. Mathie, Chloe J. Peach, Emma L. Veale, Jane F. Armstrong, Elena Faccenda, Simon D. Harding, Christopher Southan, Jamie A. Davies, Laura Amarosi, Catriona M. H. Anderson, Philip M. Beart, Stefan Broer, Paul A. Dawson, Gergely Gyimesi, Bruno Hagenbuch, James R. Hammond, Jules C. Hancox, Michal Hershfinkel, Ken‐ichi Inui, Yoshikatsu Kanai, Stephan Kemp, Edmund R. S. Kunji, Gavin Stewart, Sotiria Tavoulari, David T. Thwaites, Tiziano Verri   +28 more
wiley   +1 more source

“I'd rather die”: Patients' will and decision‐making practice in Japanese community psychiatry

Medical Anthropology Quarterly, Volume 39, Issue 4, December 2025.
Abstract Recent mental health reforms have embraced patient autonomy and shared decision‐making, where care unfolds through collaboration between clinicians and patients. However, how decision‐making can improve in marginalized psychiatric clinics remains unclear.
Yuto Kano
wiley   +1 more source

Real‐World Study on the Impact of Novel Coronavirus Infection on Male Erectile Function

Clinical Case Reports, Volume 13, Issue 11, November 2025.
ABSTRACT This study aims to examine the impact of novel coronavirus (COVID‐19) infection on male erectile function and to identify potential influencing factors. Male participants aged 18–65 years from Beijing and Shanghai were included in the study. A post‐COVID‐19 sexual function questionnaire was utilized for data collection.
Chuhong Chen, Zihan Zhou, Zhecheng Zhang, Qingtong Yi, Rujian Zhu, Xujun Xuan, Dong Liu   +6 more
wiley   +1 more source

Prognostic Value of Intrarenal Venous Flow Analysis Using Pulsed‐Wave Doppler Ultrasonography in Dogs with Myxomatous Mitral Valve Disease

Journal of Veterinary Internal Medicine, Volume 39, Issue 6, November/December 2025.
ABSTRACT Background The predictive value of intrarenal Doppler ultrasonography (IRD) analysis using pulsed‐wave Doppler for survival in dogs with myxomatous mitral valve disease (MMVD) remains unknown. Hypothesis/Objectives Impaired IRD indices, such as a high venous impedance index (VII), are associated with a short survival time in dogs with MMVD ...
Tomoya Morita, Hiroki Terukina, Masahiro Yamasaki   +2 more
wiley   +1 more source

Impact of Tamoxifen on Endometrial Thickness in Women With Thin Endometrium Following Estrogen Therapy During Frozen–Thawed Embryo Transfer

Clinical Case Reports, Volume 13, Issue 10, October 2025.
ABSTRACT Endometrial thickness (ET) is an important parameter of determining endometrial receptivity for in vitro fertilization (IVF) with frozen–thawed embryo transfer (FET). ET is influenced by various intrinsic and extrinsic factors, such as hormonal fluctuations, age‐related changes, underlying medical conditions, and metabolic factors.
Masoumeh Zaree, Bahia Namavar Jahromi, Mohammad Ebrahim Parsanezhad, Zahra Mosallanezhad, Seyedeh‐Sara Hashemi, Fatemeh YaghoobiGorgi, Alireza Salehi   +6 more
wiley   +1 more source

A Systematic Literature Review Exploring the Efficacy and Safety of Tadalafil and Sildenafil in Pulmonary Arterial Hypertension

Pulmonary Circulation, Volume 15, Issue 4, October 2025.
ABSTRACT Pulmonary Arterial Hypertension (PAH) is a rare, chronic and progressive disease affecting the heart and lungs. Endothelin receptor antagonist (ERA) + phosphodiesterase type 5 inhibitor (PDE5i) treatment is recommended for all PAH patients. The two approved PDE5is are tadalafil and sildenafil.
Rajan Saggar, Nora Rahhali, Assunta Senatore, Marinella Sandros, David Lopez, Gabriela Gomez Rendon, Ambar Khan, Ellie Boulton, Anna Bobrowska, Sandeep Sahay   +9 more
wiley   +1 more source

Ethnomedicinal Uses, Phytochemistry, Pharmacological Activities, and Toxicology of the Subfamily Gomphrenoideae (Amaranthaceae): A Comprehensive Review

Chemistry &Biodiversity, Volume 22, Issue 9, September 2025.
ABSTRACT The subfamily Gomphrenoideae is composed of about 480 accepted species, many of which have been historically used as medicinal plants, reason why they have been studied in terms of chemical profile, biological activity, and safety. This review consolidates the advances in research on this subfamily over the past 47 years, emphasizing its ...
Dayanna Isabel Araque Gelves, Giulia Cristina de Andreoli Souza, Alvaro Jose Hernandez Tasco, Marcos José Salvador   +3 more
wiley   +1 more source