Results 41 to 50 of about 3,731 (172)

Prognostic Value of Intrarenal Venous Flow Analysis Using Pulsed‐Wave Doppler Ultrasonography in Dogs with Myxomatous Mitral Valve Disease

open access: yesJournal of Veterinary Internal Medicine, Volume 39, Issue 6, November/December 2025.
ABSTRACT Background The predictive value of intrarenal Doppler ultrasonography (IRD) analysis using pulsed‐wave Doppler for survival in dogs with myxomatous mitral valve disease (MMVD) remains unknown. Hypothesis/Objectives Impaired IRD indices, such as a high venous impedance index (VII), are associated with a short survival time in dogs with MMVD ...
Tomoya Morita   +2 more
wiley   +1 more source

Impact of Tamoxifen on Endometrial Thickness in Women With Thin Endometrium Following Estrogen Therapy During Frozen–Thawed Embryo Transfer

open access: yesClinical Case Reports, Volume 13, Issue 10, October 2025.
ABSTRACT Endometrial thickness (ET) is an important parameter of determining endometrial receptivity for in vitro fertilization (IVF) with frozen–thawed embryo transfer (FET). ET is influenced by various intrinsic and extrinsic factors, such as hormonal fluctuations, age‐related changes, underlying medical conditions, and metabolic factors.
Masoumeh Zaree   +6 more
wiley   +1 more source

Sildenafil citrate therapy for IUGR and its effect on umbilical artery Doppler

open access: yesAl-Azhar Assiut Medical Journal, 2020
Background Intrauterine growth restriction (IUGR) occurs when there is deficiency of gas exchange and nutrient delivery to the fetus not allowing it to thrive in utero. This happens because of maternal diseases that decrease oxygen-carrying capacity (e.g.
Abdel A.G.E.-D.T El-Darwish   +2 more
doaj   +1 more source

A Systematic Literature Review Exploring the Efficacy and Safety of Tadalafil and Sildenafil in Pulmonary Arterial Hypertension

open access: yesPulmonary Circulation, Volume 15, Issue 4, October 2025.
ABSTRACT Pulmonary Arterial Hypertension (PAH) is a rare, chronic and progressive disease affecting the heart and lungs. Endothelin receptor antagonist (ERA) + phosphodiesterase type 5 inhibitor (PDE5i) treatment is recommended for all PAH patients. The two approved PDE5is are tadalafil and sildenafil.
Rajan Saggar   +9 more
wiley   +1 more source

Ethnomedicinal Uses, Phytochemistry, Pharmacological Activities, and Toxicology of the Subfamily Gomphrenoideae (Amaranthaceae): A Comprehensive Review

open access: yesChemistry &Biodiversity, Volume 22, Issue 9, September 2025.
ABSTRACT The subfamily Gomphrenoideae is composed of about 480 accepted species, many of which have been historically used as medicinal plants, reason why they have been studied in terms of chemical profile, biological activity, and safety. This review consolidates the advances in research on this subfamily over the past 47 years, emphasizing its ...
Dayanna Isabel Araque Gelves   +3 more
wiley   +1 more source

Chondrodystrophic Dogs as a Preclinical Large Animal Model of Discogenic Back Pain

open access: yesJOR SPINE, Volume 8, Issue 3, September 2025.
This study aims to validate an underutilized canine preclinical model of discogenic back pain model by deep phenotyping several structural and pain associated outcomes with novel findings in the areas of RNA sequencing and whole patch clamp of canine dorsal root ganglion neurons.
Mary K. Heimann   +18 more
wiley   +1 more source

Identifying Causal Inflammatory Factors With Gene Mediators and Potential Drugs for Bronchiectasis

open access: yesMedicine Advances, Volume 3, Issue 3, Page 158-170, September 2025.
Four inflammatory factors were identified with causal links to bronchiectasis: macrophage migration inhibitory factor (MMIF) showed a protective effect, whereas interleukin‐4 (IL‐4), interferon‐gamma (IFN‐γ), and basic fibroblast growth factor (FGF‐Basic) were associated with increased risk.
Wanzhe Liao   +11 more
wiley   +1 more source

Dual Role of Natural Killer Cells in Early Pregnancy: Immunopathological Implications and Therapeutic Potential in Recurrent Spontaneous Abortion and Recurrent Implantation Failure

open access: yesCell Proliferation, Volume 58, Issue 9, September 2025.
This article elaborates on the role of NK cells in early pregnancy from multiple perspectives, including molecular mechanisms and therapeutic interventions. It also discusses how NK cell dysfunction contributes to RSA and RIF, aiming to provide insights for future research on NK cell mechanisms and clinical treatment of RSA and RIF.
Defeng Guan   +5 more
wiley   +1 more source

Intraoral Drug Delivery: Bridging the Gap Between Academic Research and Industrial Innovations

open access: yesAdvanced Functional Materials, Volume 35, Issue 35, August 28, 2025.
Intraoral drug delivery offers a promising route for systemic and localized therapies, yet challenges such as enzymatic degradation, limited permeability, and microbial interactions hinder efficacy. This figure highlights innovative strategies—mucoadhesive materials, enzyme inhibitors, and permeation enhancers—to overcome these barriers.
Soheil Haddadzadegan   +4 more
wiley   +1 more source

EFFECT OF SILDENAFIL CITRATE ON THE BODY WEIGHT, BLOOD GLUCOSE AND WHITE BLOOD CELL COUNT DURING WOUND HEALING PROCESS IN DIABETIC RATS [PDF]

open access: yesKanem Journal of Medical Sciences, 2016
Background: Diabetes mellitus is a chronic metabolic disorder with major complication of delayed wound healing. Objectives: The purpose of this study was to evaluate the effect of sildenafil on blood glucose level, body weight and leucocyte count during ...
Ngulde SI   +8 more
doaj  

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