Results 61 to 70 of about 3,813 (172)

Sildenafil Citrate Therapy for Pulmonary Arterial Hypertension

New England Journal of Medicine, 2005
Sildenafil inhibits phosphodiesterase type 5, an enzyme that metabolizes cyclic guanosine monophosphate, thereby enhancing the cyclic guanosine monophosphate-mediated relaxation and growth inhibition of vascular smooth-muscle cells, including those in the lung.In this double-blind, placebo-controlled study, we randomly assigned 278 patients with ...
GALIE', NAZZARENO, Ghofrani, Hossein A., Torbicki, Adam, Barst, Robyn J., Rubin, Lewis J., Badesch, David, Fleming, Thomas, Parpia, Tamiza, Burgess, Gary, BRANZI, ANGELO, Grimminger, Friedrich, Kurzyna, Marcin, Simonneau, Gérald   +12 more
openaire   +2 more sources

Chondrodystrophic Dogs as a Preclinical Large Animal Model of Discogenic Back Pain

JOR SPINE, Volume 8, Issue 3, September 2025.
This study aims to validate an underutilized canine preclinical model of discogenic back pain model by deep phenotyping several structural and pain associated outcomes with novel findings in the areas of RNA sequencing and whole patch clamp of canine dorsal root ganglion neurons.
Mary K. Heimann, Shirley N. Tang, Gilian Gunsch, Kyle Kuchynsky, Brett Klamer, Fangli Zhao, Megan Co, Maciej Pietrzak, Justin Richards, Jake Klausner, Adam Smith, Kaitlyn Cimney, Sara McBride‐Gagyi, Brad Youngblood, Kara Corps, Candice Askwith, Benjamin A. Walter, Sarah A. Moore, Devina Purmessur   +18 more
wiley   +1 more source

Identifying Causal Inflammatory Factors With Gene Mediators and Potential Drugs for Bronchiectasis

Medicine Advances, Volume 3, Issue 3, Page 158-170, September 2025.
Four inflammatory factors were identified with causal links to bronchiectasis: macrophage migration inhibitory factor (MMIF) showed a protective effect, whereas interleukin‐4 (IL‐4), interferon‐gamma (IFN‐γ), and basic fibroblast growth factor (FGF‐Basic) were associated with increased risk.
Wanzhe Liao, Haobin Zhou, Zhuofeng Wen, Weixuan Liang, Chongde Pan, Zhiyi Zhou, Jingzhang Sun, Chang Liu, Xiangdong Zhou, Naijun Yuan, Qi Li, Chuiguo Huang   +11 more
wiley   +1 more source

Dual Role of Natural Killer Cells in Early Pregnancy: Immunopathological Implications and Therapeutic Potential in Recurrent Spontaneous Abortion and Recurrent Implantation Failure

Cell Proliferation, Volume 58, Issue 9, September 2025.
This article elaborates on the role of NK cells in early pregnancy from multiple perspectives, including molecular mechanisms and therapeutic interventions. It also discusses how NK cell dysfunction contributes to RSA and RIF, aiming to provide insights for future research on NK cell mechanisms and clinical treatment of RSA and RIF.
Defeng Guan, Zhou Chen, Yuhua Zhang, Wenjie Sun, Lifei Li, Xia Huang   +5 more
wiley   +1 more source

EFFECT OF SILDENAFIL CITRATE ON THE BODY WEIGHT, BLOOD GLUCOSE AND WHITE BLOOD CELL COUNT DURING WOUND HEALING PROCESS IN DIABETIC RATS [PDF]

Kanem Journal of Medical Sciences, 2016
Background: Diabetes mellitus is a chronic metabolic disorder with major complication of delayed wound healing. Objectives: The purpose of this study was to evaluate the effect of sildenafil on blood glucose level, body weight and leucocyte count during ...
Ngulde SI, Umaru B, Mahre MB, William A, Agbutun PA, Midda YH, Atela PE, Daniel HM, Giwa-Imam LN   +8 more
doaj  

EXPERIMENTAL STUDY: THE EFFICACY AND DOSAGE OF SILDENAFIL CITRATE ON FLAP VIABILITY

Urology Research and Practice, 2019
Introduction: Various agents have been studied to observe the effects on flap viability, necrosis and the wound healing. Sildenafil citrate is a phospodiesterase type 5 enzyme inhibitor, which increases cGMP levels, is used generally in the treatment of ...
Ali Ayyıldız, Barış Nuhoğlu, Emre Huri, Afşin Uysal, Hüseyin ÜSTÜN, Cankon GERMİYANOĞLU   +5 more
doaj   +2 more sources

Protective effect of sildenafil citrate on contralateral testis injury after unilateral testicular torsion/detorsion

Clinics, 2011
OBJECTIVES: This study was designed to investigate prevention of contralateral testicular injury with sildenafil citrate after unilateral testicular torsion/detorsion.
Hamit Yíldíz, Ali Said Durmus, Halil Şimşek, Mine Yaman   +3 more
doaj  

Comparison of the effect of Elaeagnus angustifolia flower capsule and sildenafil citrate tablet female sexual interest/arousal disorder in clinical trial study

Journal of Family Medicine and Primary Care, 2019
Background and Aims: Sexual desire is one of the main issues affecting people's individual and social life. The present study aimed to compare the effects of Elaeagnus angustifolia extract and sildenafil citrate tablet on female sexual interest/arousal ...
Sanaz Zeinalzadeh, Abdol Ali Mohagheghzadeh, Fatemeh Ahmadinezhad, Marzieh Akbarzadeh   +3 more
doaj   +1 more source

Finger roots (Uvaria chemea) and African greenheart (Cylicodiscus gabunensis): Alternative potent therapy to sildenafil in erectile dysfunction

Phytomedicine Plus
Background and aim: Erectile dysfunction (ED) is a prevalent condition affecting men worldwide, characterized by the inability to achieve or maintain an erection sufficient for sexual intercourse. Traditional herbal remedies, rooted in cultural practices,
Etukudo Okon Jimmy, Grace Edet Bassey, Abijah Ekwere, Udoh Idorenyin Umoh, Adeyemi Fatai Odetayo, Udoh Nsikan Malachy   +5 more
doaj   +1 more source

A Comparison of Nifedipine Versus a Combination of Nifedipine and Sildenafil Citrate in the Management of Preterm Labour. [PDF]

Cureus, 2023
Hassan A, Waseem H, AlDardeir N, Nasief H, Khadawardi K, Alwazzan AB, Alothmani H, Hammad Z.   +7 more
europepmc   +1 more source