Results 71 to 80 of about 9,248 (216)

Erectile dysfunction and its management in patients with diabetes mellitus [PDF]

, 2015
Diabetes can be described as a syndrome of multiple closely related conditions induced by a chronic state of hyperglycaemia resulting from defective insulin secretion, insulin action or both.
DEFEUDIS, GIUSEPPE, Di Emidio, Chiara, GIANFRILLI, DANIELE, LENZI, Andrea, Palermo, Andrea, POFI, RICCARDO, Pozzilli, Paolo, Tuccinardi, Dario   +7 more
core   +1 more source

Ethnomedicinal Uses, Phytochemistry, Pharmacological Activities, and Toxicology of the Subfamily Gomphrenoideae (Amaranthaceae): A Comprehensive Review

Chemistry &Biodiversity, Volume 22, Issue 9, September 2025.
ABSTRACT The subfamily Gomphrenoideae is composed of about 480 accepted species, many of which have been historically used as medicinal plants, reason why they have been studied in terms of chemical profile, biological activity, and safety. This review consolidates the advances in research on this subfamily over the past 47 years, emphasizing its ...
Dayanna Isabel Araque Gelves, Giulia Cristina de Andreoli Souza, Alvaro Jose Hernandez Tasco, Marcos José Salvador   +3 more
wiley   +1 more source

Spectrofluorimetric determination of sildenafil: a new analytical alternative for its analysis [PDF]

, 2012
In aqueous solutions, sildenafil presents a very low fluorescence emission and a limited linear range. In presence of a cationic surfactant hexadecyltrim ethylammonium bromide (HTAB, method A) and anionic surfactant sodium dodecyl sulfate (SDS, method B)
Fernandez, Liliana Patricia, Wang, Chien Chun   +1 more
core  

Sildenafil restores cognitive function without affecting β-amyloid burden in a mouse model of Alzheimer's disease [PDF]

, 2011
BACKGROUND AND PURPOSE: Inhibitors of phosphodiesterase 5 (PDE5) affect signalling pathways by elevating cGMP, which is a second messenger involved in processes of neuroplasticity.
Aguirre, N. (Norberto), Cuadrado-Tejedor, M. (Mar), Franco, R. (Rafael), Garcia-Barroso, C. (C.), Garcia-Osta, A. (Ana), Hervias, I. (Isabel), Perez-Roldan, J.M. (J.M.), Puerta, E. (Elena), Ricobaraza, A. (Ana)   +8 more
core   +1 more source

Chondrodystrophic Dogs as a Preclinical Large Animal Model of Discogenic Back Pain

JOR SPINE, Volume 8, Issue 3, September 2025.
This study aims to validate an underutilized canine preclinical model of discogenic back pain model by deep phenotyping several structural and pain associated outcomes with novel findings in the areas of RNA sequencing and whole patch clamp of canine dorsal root ganglion neurons.
Mary K. Heimann, Shirley N. Tang, Gilian Gunsch, Kyle Kuchynsky, Brett Klamer, Fangli Zhao, Megan Co, Maciej Pietrzak, Justin Richards, Jake Klausner, Adam Smith, Kaitlyn Cimney, Sara McBride‐Gagyi, Brad Youngblood, Kara Corps, Candice Askwith, Benjamin A. Walter, Sarah A. Moore, Devina Purmessur   +18 more
wiley   +1 more source

Non-human tools for the evaluation of bitter taste in the design and development of medicines: a systematic review [PDF]

, 2016
Taste evaluation is a crucial factor for determining acceptance of medicines by patients. The human taste panel test is the main method used to establish the overall palatability and acceptability of a drug product to a patient towards the end of ...
Ernest, T, Mohamed-Ahmed, AH, Soto, J, Tuleu, C   +3 more
core   +2 more sources

Identifying Causal Inflammatory Factors With Gene Mediators and Potential Drugs for Bronchiectasis

Medicine Advances, Volume 3, Issue 3, Page 158-170, September 2025.
Four inflammatory factors were identified with causal links to bronchiectasis: macrophage migration inhibitory factor (MMIF) showed a protective effect, whereas interleukin‐4 (IL‐4), interferon‐gamma (IFN‐γ), and basic fibroblast growth factor (FGF‐Basic) were associated with increased risk.
Wanzhe Liao, Haobin Zhou, Zhuofeng Wen, Weixuan Liang, Chongde Pan, Zhiyi Zhou, Jingzhang Sun, Chang Liu, Xiangdong Zhou, Naijun Yuan, Qi Li, Chuiguo Huang   +11 more
wiley   +1 more source

Dual Role of Natural Killer Cells in Early Pregnancy: Immunopathological Implications and Therapeutic Potential in Recurrent Spontaneous Abortion and Recurrent Implantation Failure

Cell Proliferation, Volume 58, Issue 9, September 2025.
This article elaborates on the role of NK cells in early pregnancy from multiple perspectives, including molecular mechanisms and therapeutic interventions. It also discusses how NK cell dysfunction contributes to RSA and RIF, aiming to provide insights for future research on NK cell mechanisms and clinical treatment of RSA and RIF.
Defeng Guan, Zhou Chen, Yuhua Zhang, Wenjie Sun, Lifei Li, Xia Huang   +5 more
wiley   +1 more source

Response to pulmonary arterial hypertension drug therapies in patients with pulmonary arterial hypertension and cardiovascular risk factors. [PDF]

, 2014
The age at diagnosis of pulmonary arterial hypertension (PAH) and the prevalence of cardiovascular (CV) risk factors are increasing. We sought to determine whether the response to drug therapy was influenced by CV risk factors in PAH patients. We studied
Charalampopoulos, A, Connolly, SB, Davies, RJ, Gibbs, JS, Gin-Sing, W, Grapsa, J, Howard, LS, Nihoyannopoulos, P, Tzoulaki, I, Wilkins, MR   +9 more
core   +1 more source

Intraoral Drug Delivery: Bridging the Gap Between Academic Research and Industrial Innovations

Advanced Functional Materials, Volume 35, Issue 35, August 28, 2025.
Intraoral drug delivery offers a promising route for systemic and localized therapies, yet challenges such as enzymatic degradation, limited permeability, and microbial interactions hinder efficacy. This figure highlights innovative strategies—mucoadhesive materials, enzyme inhibitors, and permeation enhancers—to overcome these barriers.
Soheil Haddadzadegan, Simona Summonte, Fabrizio Ricci, Matthias Sandmeier, Andreas Bernkop‐Schnürch   +4 more
wiley   +1 more source