Results 51 to 60 of about 3,731 (172)

Vitamin D deficiency induces erectile dysfunction: Role of superoxide and Slpi

British Journal of Pharmacology, Volume 182, Issue 15, Page 3669-3687, August 2025.
Background and Purpose Epidemiological studies suggest a relationship between vitamin D deficiency and erectile dysfunction (ED). We hypothesized that vitamin D deficiency or vitamin D receptor (VDR) knockout causes ED and analysed the underlying molecular mechanisms.
Miguel A. Olivencia, Belén Climent, Bianca Barreira, Daniel Morales‐Cano, Ana Sánchez, Argentina Fernández, Borja García‐Gómez, Javier Romero‐Otero, Claudia Rodríguez, Laura Moreno, Dolores Prieto, María Jesús Larriba, Angel Cogolludo, Javier Angulo, Francisco Perez‐Vizcaino   +14 more
wiley   +1 more source

Xanthine Derivative KMUP‐3 Alleviates Periodontal Bone Resorption by Inhibiting Osteoclastogenesis and Macrophage Pyroptosis

Journal of Periodontal Research, Volume 60, Issue 7, Page 723-736, July 2025.
This study reveals that our self‐developed xanthine derivative, KMUP‐3, suppresses osteoclastogenesis, inflammation, and pyroptosis by inhibiting the NLRP3 inflammasome. It also alleviates periodontal bone loss in periodontitis rats, highlighting its potential as a novel therapeutic option for periodontitis.
Shang‐En Huang, Kai‐Fang Hu, Meng‐Xuan Lin, Ching‐Jiunn Tseng, Bin‐Nan Wu, Zen‐Kong Dai, Jong‐Hau Hsu, Jwu‐Lai Yeh   +7 more
wiley   +1 more source

Progress and Application of Multifunctional Hydrogel in Radioactive Skin Injury

Advanced Materials Interfaces, Volume 12, Issue 11, June 9, 2025.
This review examines healing challenges in radiation‐wound injuries, where ionizing radiation impairs immune and tissue repair processes. Hydrogels, with their biocompatibility, antimicrobial properties, and drug delivery capabilities, present a transformative solution. It compares hydrogel efficacy in radiation‐induced versus common wounds, highlights
Xinyue Cui, Jingyi Wang, Xinyi Xu, Xiqian Cao, Yingtang Zhou, Jiaming Guo   +5 more
wiley   +1 more source

EXPERIMENTAL STUDY: THE EFFICACY AND DOSAGE OF SILDENAFIL CITRATE ON FLAP VIABILITY

Urology Research and Practice, 2019
Introduction: Various agents have been studied to observe the effects on flap viability, necrosis and the wound healing. Sildenafil citrate is a phospodiesterase type 5 enzyme inhibitor, which increases cGMP levels, is used generally in the treatment of ...
Ali Ayyıldız, Barış Nuhoğlu, Emre Huri, Afşin Uysal, Hüseyin ÜSTÜN, Cankon GERMİYANOĞLU   +5 more
doaj   +2 more sources

Comparison of the effect of Elaeagnus angustifolia flower capsule and sildenafil citrate tablet female sexual interest/arousal disorder in clinical trial study

Journal of Family Medicine and Primary Care, 2019
Background and Aims: Sexual desire is one of the main issues affecting people's individual and social life. The present study aimed to compare the effects of Elaeagnus angustifolia extract and sildenafil citrate tablet on female sexual interest/arousal ...
Sanaz Zeinalzadeh, Abdol Ali Mohagheghzadeh, Fatemeh Ahmadinezhad, Marzieh Akbarzadeh   +3 more
doaj   +1 more source

Validation and Stability Indicating RP-HPLC Method for the Determination of Sildenafil Citrate in Pharmaceutical Formulations and Human Plasma

E-Journal of Chemistry, 2008
A simple, selective, accurate reverse phase-high performance liquid chromatographic (RP-HPLC) method was developed and validated for the analysis of sildenafil citrate in pharmaceutical formulations. Chromatographic separation achieved isocratically on a
B. Prasanna Kumar Reddy, Y. Ramanjaneya Reddy   +1 more
doaj   +1 more source

Development and stability assessment of liquid paediatric formulations containing sildenafil citrate

Brazilian Journal of Pharmaceutical Sciences, 2013
The purpose of this study is to develop and improve oral liquids formulations of sildenafil citrate for paediatric use. Four different formulations were developed, which are as follows: two aqueous solutions of sildenafil citrate (2.5 mg/mL), with or ...
Fátima Roque, Ana Cristina Rama, João José Sousa, Maria Eugénia Pina   +3 more
doaj   +1 more source

Protective effect of sildenafil citrate on contralateral testis injury after unilateral testicular torsion/detorsion

Clinics, 2011
OBJECTIVES: This study was designed to investigate prevention of contralateral testicular injury with sildenafil citrate after unilateral testicular torsion/detorsion.
Hamit Yíldíz, Ali Said Durmus, Halil Şimşek, Mine Yaman   +3 more
doaj  

Finger roots (Uvaria chemea) and African greenheart (Cylicodiscus gabunensis): Alternative potent therapy to sildenafil in erectile dysfunction

Phytomedicine Plus
Background and aim: Erectile dysfunction (ED) is a prevalent condition affecting men worldwide, characterized by the inability to achieve or maintain an erection sufficient for sexual intercourse. Traditional herbal remedies, rooted in cultural practices,
Etukudo Okon Jimmy, Grace Edet Bassey, Abijah Ekwere, Udoh Idorenyin Umoh, Adeyemi Fatai Odetayo, Udoh Nsikan Malachy   +5 more
doaj   +1 more source

Determinação espectrofotométrica de citrato de sildenafil em formulações farmacêuticas Spectrophotometric determination of sildenafil citrate in pharmaceutical formulations

Química Nova, 2008
This paper describes a simple and rapid spectrophotometric method for quantitative determination of sildenafil citrate based on its reaction with p-chloranil accelerated by hydrogen peroxide, producing a stable purple compound (λmax= 535 nm). In the
Patrícia Los Weinert, Leonardo Pezza, Helena Redigolo Pezza   +2 more
doaj   +1 more source