Results 81 to 90 of about 10,448 (268)

Clinical Outcomes of Mitral Valve Repair in Dogs With Pulmonary Hypertension Secondary to Myxomatous Mitral Valve Disease

Journal of Veterinary Internal Medicine, Volume 39, Issue 3, May/June 2025.
ABSTRACT Background Myxomatous mitral valve disease (MMVD) can cause pulmonary hypertension (PH). Mitral valve repair (MVR) has been described as a surgical treatment option for MMVD, but the benefit of MVR when PH is present is unknown. Hypothesis/Objectives To investigate the change in echocardiographic variables and long‐term outcomes of dogs with ...
Tomohiko Yoshida, Darcy Adin, Katsuhiro Matsuura   +2 more
wiley   +1 more source

EFFECT OF SILDENAFIL CITRATE ON THE BODY WEIGHT, BLOOD GLUCOSE AND WHITE BLOOD CELL COUNT DURING WOUND HEALING PROCESS IN DIABETIC RATS [PDF]

Kanem Journal of Medical Sciences, 2016
Background: Diabetes mellitus is a chronic metabolic disorder with major complication of delayed wound healing. Objectives: The purpose of this study was to evaluate the effect of sildenafil on blood glucose level, body weight and leucocyte count during ...
Ngulde SI, Umaru B, Mahre MB, William A, Agbutun PA, Midda YH, Atela PE, Daniel HM, Giwa-Imam LN   +8 more
doaj  

Comparison of the effect of Elaeagnus angustifolia flower capsule and sildenafil citrate tablet female sexual interest/arousal disorder in clinical trial study

Journal of Family Medicine and Primary Care, 2019
Background and Aims: Sexual desire is one of the main issues affecting people's individual and social life. The present study aimed to compare the effects of Elaeagnus angustifolia extract and sildenafil citrate tablet on female sexual interest/arousal ...
Sanaz Zeinalzadeh, Abdol Ali Mohagheghzadeh, Fatemeh Ahmadinezhad, Marzieh Akbarzadeh   +3 more
doaj   +1 more source

Sildenafil citrate protects skeletal muscle of ischemia-reperfusion injury: immunohistochemical study in rat model [PDF]

Acta Cirúrgica Brasileira, 2013
PURPOSE: To investigate the effect of sildenafil citrate (SC) on skeletal muscle ischemia-reperfusion (IR) injury in rats. METHODS: Adult male Wistar rats were randomized into three groups: vehicle-treated control (CTG), sildenafil citrate-treated (SCG),
Dinani Matoso Fialho de Oliveira Armstrong, Anderson da Costa Armstrong, Regina Célia Bressan Queiroz Figueiredo, Joao Eduardo Florentino, Paulo Fernandes Saad, Karen Fox-Talbot, Marc Kenneth Halushka, Dan E. Berkowitz, Murched Omar Taha, Djalma José Fagundes   +9 more
doaj   +2 more sources

The effect of sildenafil citrate (Viagra®) on visual sensitivity

Journal of Vision, 2007
The erectile dysfunction medicine sildenafil citrate (Viagra) inhibits phosphodiesterase type 6 (PDE6), an essential enzyme involved in the activation and modulation of the phototransduction cascade. Although Viagra might thus be expected to impair visual performance, reports of deficits following its ingestion have so far been largely inconclusive or ...
Glen Jeffery, Adnan Tufail, Andrew Stockman, Lindsay T. Sharpe, Philip Kell, Caterina Ripamonti   +5 more
openaire   +3 more sources

Vascular remodeling in arteriovenous fistula treated with PDE5A inhibitors

Physiological Reports, Volume 13, Issue 9, May 2025.
Abstract The arteriovenous fistula (AVF) is the lifeline for hemodialysis patients. However, there are currently no effective therapies promoting AVF maturation. AVF dilation by smooth muscle cell relaxation, through increased cyclic guanosine monophosphate (cGMP), is one potential mechanism to improve AVF remodeling.
Maheshika Somarathna, Hannah Northrup, Kevin Ingle, Tatyana Isayeva‐Waldrop, Nguyen Thuy Nhu Nguyen, Bailey Lose, Yan‐Ting Shiu, Timmy Lee   +7 more
wiley   +1 more source

Pulmonary Hypertension: Molecular Mechanisms and Clinical Studies

MedComm, Volume 6, Issue 3, March 2025.
The figure highlights the interplay of genetic and epigenetic mechanisms in pulmonary hypertension (PH) and their implications for therapeutic strategies. The genetic mechanism section features key genes implicated in PH pathogenesis. The epigenetic mechanism encompasses DNA methylation, RNA methylation, noncoding RNAs (miRNA, lncRNA), and histone ...
Joseph Adu‐Amankwaah, Qiang You, Xiaoer Liu, Jiayi Jiang, Dongqi Yang, Kuntao Liu, Jinxiang Yuan, Yanfang Wang, Qinghua Hu, Rubin Tan   +9 more
wiley   +1 more source

A survey of Top 200 Drugs—Inconsistent Practice of Drug Strength Expression for Drugs Containing Salt Forms [PDF]

, 2012
Many ionizable drugs are developed and marketed as salt forms. However, there are no clear US regulatory guidelines on drug strength labeling for salts. The strengths of some drugs are expressed as salts and some as free acids/bases.
Prohotsky, Daniel, Zhao, Fang
core   +2 more sources

Testosterone and men's health: An in‐depth exploration of their relationship

UroPrecision, Volume 3, Issue 1, Page 36-46, March 2025.
Abstract Testosterone plays a pivotal role in male health throughout the lifespan. Men generally exhibit higher serum testosterone levels than women, influencing critical aspects of male physiology. It drives normal sexual differentiation during fetal development, promotes the acquisition of pubertal traits, and induces the development of secondary ...
Aksam Yassin, Raed M. Al‐Zoubi, Raidh Talib Alzubaidi, Hatem Kamkoum, Ayman A. Zarour, Khalil Garada, Mai Elaarag, Ahmad R. Al‐Qudimat, Zainab E. Fares, Abdulla A. Al‐Ansari   +9 more
wiley   +1 more source

Sildenafil for the Treatment of Pulmonary Hypertension in Pediatric Patients [PDF]

, 2009
Sildenafil is a phosphodiesterase 5 inhibitor widely used for the treatment of pulmonary hypertension in children. Despite limited available safety and efficacy evidence, use of sildenafil continues to increase.
Ebenroth, Eric S., Huddleston, Alice J., Knoderer, Chad A., Morris, Jennifer L.   +3 more
core   +2 more sources