Silent Synapse-Based Mechanisms of Critical Period Plasticity [PDF]
Frontiers in Cellular Neuroscience, 2020 Critical periods are postnatal, restricted time windows of heightened plasticity in cortical neural networks, during which experience refines principal neuron wiring configurations.
Weifeng Xu +7 more
doaj +7 more sources
Accurate Silent Synapse Estimation from Simulator-Corrected Electrophysiological Data Using the SilentMLE Python Package [PDF]
STAR Protocols, 2020 Summary: The proportion of silent (AMPAR-lacking) synapses is thought to be related to the plasticity potential of neural networks. We created a maximum-likelihood estimator of silent synapse fraction based on simulations of the underlying experimental ...
Michael Lynn +2 more
doaj +3 more sources
Location analysis of presynaptically active and silent synapses in single-cultured hippocampal neurons [PDF]
Frontiers in Neural CircuitsA morphologically present but non-functioning synapse is termed a silent synapse. Silent synapses are categorized into “postsynaptically silent synapses,” where AMPA receptors are either absent or non-functional, and “presynaptically silent synapses ...
Otoya Kitaoka +8 more
doaj +4 more sources
The Integrative Function of Silent Synapses on Subplate Neurons in Cortical Development and Dysfunction [PDF]
Frontiers in Neuroanatomy, 2019 The thalamocortical circuit is of central importance in relaying information to the cortex. In development, subplate neurons (SPNs) form an integral part of the thalamocortical pathway.
Patrick O. Kanold +2 more
doaj +2 more sources
Brain-derived neurotrophic factor signaling in the neuromuscular junction during developmental axonal competition and synapse elimination [PDF]
Neural Regeneration Research, 2023 During the development of the nervous system, there is an overproduction of neurons and synapses. Hebbian competition between neighboring nerve endings and synapses performing different activity levels leads to their elimination or strengthening. We have
Josep Tomàs +9 more
doaj +2 more sources
A functional screen uncovers circular RNAs regulating excitatory synaptogenesis in hippocampal neurons [PDF]
Nature CommunicationsCircular RNAs (circRNAs) are an expanding class of largely unexplored RNAs which are prominently enriched in the mammalian brain. Here, we systematically interrogate their role in excitatory synaptogenesis of rat hippocampal neurons using RNA ...
Darren Kelly +6 more
doaj +3 more sources
Sleep need driven oscillation of glutamate synaptic phenotype [PDF]
eLifeSleep loss increases AMPA-synaptic strength and number in the neocortex. However, this is only part of the synaptic sleep loss response. We report an increased AMPA/NMDA EPSC ratio in frontal-cortical pyramidal neurons of layers 2–3.
Kaspar E Vogt +5 more
doaj +2 more sources
Bioinspired activation of silent synapses in layered materials for extensible neuromorphic computing
Journal of Materiomics, 2023 Activation of silent synapses is of great significance for the extension of neural plasticity related to learning and memory. Inspired by the activation of silent synapses via receptor insertion in neural synapses, we propose an efficient method for ...
Yan Kang +7 more
doaj +2 more sources
Ribbon synapse plasticity in the cochleae of Guinea pigs after noise-induced silent damage.
PLoS ONE, 2013 Noise exposure at low levels or low doses can damage hair cell afferent ribbon synapses without causing permanent threshold shifts. In contrast to reports in the mouse cochleae, initial damage to ribbon synapses in the cochleae of guinea pigs is largely ...
Lijuan Shi +6 more
doaj +3 more sources
MET receptor tyrosine kinase promotes the generation of functional synapses in adult cortical circuits [PDF]
Neural Regeneration ResearchLoss of synapse and functional connectivity in brain circuits is associated with aging and neurodegeneration, however, few molecular mechanisms are known to intrinsically promote synaptogenesis or enhance synapse function.
Yuehua Cui +9 more
doaj +2 more sources