Silent Synapse-Based Mechanisms of Critical Period Plasticity [PDF]
Frontiers in Cellular Neuroscience, 2020 Critical periods are postnatal, restricted time windows of heightened plasticity in cortical neural networks, during which experience refines principal neuron wiring configurations.
Weifeng Xu +7 more
doaj +7 more sources
Silent Synapse-Based Circuitry Remodeling in Drug Addiction [PDF]
International Journal of Neuropsychopharmacology, 2015 Exposure to cocaine, and likely other drugs of abuse, generates α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor-silent glutamatergic synapses in the nucleus accumbens.
Yan Dong
semanticscholar +5 more sources
Location analysis of presynaptically active and silent synapses in single-cultured hippocampal neurons [PDF]
Frontiers in Neural CircuitsA morphologically present but non-functioning synapse is termed a silent synapse. Silent synapses are categorized into “postsynaptically silent synapses,” where AMPA receptors are either absent or non-functional, and “presynaptically silent synapses ...
Otoya Kitaoka +8 more
doaj +4 more sources
Accurate Silent Synapse Estimation from Simulator-Corrected Electrophysiological Data Using the SilentMLE Python Package [PDF]
STAR Protocols, 2020 Summary: The proportion of silent (AMPAR-lacking) synapses is thought to be related to the plasticity potential of neural networks. We created a maximum-likelihood estimator of silent synapse fraction based on simulations of the underlying experimental ...
Michael Lynn +2 more
doaj +3 more sources
Silent synapses dictate cocaine memory destabilization and reconsolidation [PDF]
Nature Neuroscience, 2019 Cocaine-associated memories are persistent, but, on retrieval, become temporarily destabilized and vulnerable to disruptions, followed by reconsolidation.
William J. Wright +13 more
semanticscholar +6 more sources
Diminished Neuronal Activity Increases Neuron-Neuron Connectivity Underlying Silent Synapse Formation and the Rapid Conversion of Silent to Functional Synapses [PDF]
The Journal of Neuroscience, 2005 Neuronal activity regulates the synaptic strength of neuronal networks. However, it is still unclear how diminished activity changes connection patterns in neuronal circuits.
Kimiko Nakayama +2 more
semanticscholar +4 more sources
Silent Synapses in Cocaine-Associated Memory and Beyond [PDF]
The Journal of Neuroscience, 2021 Glutamatergic synapses are key cellular sites where cocaine experience creates memory traces that subsequently promote cocaine craving and seeking. In addition to making across-the-board synaptic adaptations, cocaine experience also generates a discrete ...
William J. Wright, Yan Dong
semanticscholar +4 more sources
Silent Synapse Activation in Epilepsy [PDF]
Journal of Neurology & Stroke, 2016 Epilepsy is a life-threatening chronic disease in a state of neuronal over electric activity. The precise nature of the seizure recurrence has not been clearly.
Zhi-Qin Xi
semanticscholar +4 more sources
Presynaptically silent synapses are modulated by the density of surrounding astrocytes [PDF]
Journal of Pharmacological Sciences, 2020 Astrocytes, comprising the primary glial-cell type, are involved in the formation and maturation of synapses, and thus contribute to sustainable synaptic transmission between neurons.
Kohei Oyabu +7 more
doaj +3 more sources
A synthetic likelihood solution to the silent synapse estimation problem [PDF]
bioRxiv, 2019 The proportions of AMPA-lacking silent synapses are believed to play a fundamental role in determining the plasticity potential of neural networks. It is, however, unclear whether current methods to quantify silent synapses possess adequate estimation ...
Michael Lynn +4 more
openalex +2 more sources