Results 161 to 170 of about 24,094 (177)
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Trends in Neurosciences, 2018
The ability of central synapses to undergo long-term potentiation (LTP) still captures the imagination of scientists and has become one of the most fascinating and deeply studied questions in modern neuroscience. By the mid-1990s, however, the field was deeply ensnarled in trying to answer a passionately dichotomous question: is LTP expressed by a pre-
Philippe Vincent-Lamarre +2 more
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The ability of central synapses to undergo long-term potentiation (LTP) still captures the imagination of scientists and has become one of the most fascinating and deeply studied questions in modern neuroscience. By the mid-1990s, however, the field was deeply ensnarled in trying to answer a passionately dichotomous question: is LTP expressed by a pre-
Philippe Vincent-Lamarre +2 more
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Silent glutamatergic synapses in the mammalian brain
Canadian Journal of Physiology and Pharmacology, 1999Excitatory synaptic transmission in the mammalian brain is mediated primarily by α-amino-3-hydroxy-5-methylisoxazolepropionic acid (AMPA) and N-methyl-D-aspartate (NMDA) receptors that are thought to be co-localized at individual synapses. However, recent electrophysiological and anatomical data suggest that the synaptic localization of AMPA and NMDA ...
John T.R. Isaac +2 more
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Silent synapses in neuromuscular junction development
Journal of Neuroscience Research, 2010AbstractIn the last few years, evidence has been found to suggest that some synaptic contacts become silent but can be functionally recruited before they completely retract during postnatal synapse elimination in muscle. The physiological mechanism of developmental synapse elimination may be better understood by studying this synapse recruitment.
Nuria Besalduch +5 more
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AMPA-silent synapses in brain development and pathology [PDF]
Nature Reviews Neuroscience, 2013 Synapses are constantly generated at a high rate in the developing, prepubescent brain. Newly generated glutamatergic synapses lack functional AMPA receptor-mediated transmission. Most of these 'AMPA-silent' synapses are eliminated during the developmental period, but some are specifically selected for AMPA unsilencing by correlated pre-and ...
Eric Hanse, Henrik Seth, Ilse Riebe
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Activity‐Dependent Recruitment of Silent Synapsesa
Annals of the New York Academy of Sciences, 1991At the crayfish neuromuscular junction, a long-lasting enhancement of synaptic transmission can be induced by tetanic stimulation of 10-20 Hz for several minutes. The long-lasting enhancement is presynaptic in origin, because quantal content increases but not quantal size, and is not dependent upon broadening or enlargement of the presynaptic action ...
Harold L. Atwood +2 more
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Filopodia are a structural substrate for silent synapses in adult neocortex
Nature, 2022Newly generated excitatory synapses in the mammalian cortex lack sufficient AMPA-type glutamate receptors to mediate neurotransmission, resulting in functionally silent synapses that require activity-dependent plasticity to mature. Silent synapses are abundant in early development, during which they mediate circuit formation and refinement, but they ...
Dimitra Vardalaki +2 more
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Silent Synapses in the Adult Brain
Annual Review of NeuroscienceThe formation of new synapses, the connections between neurons, is the critical step for neural circuit assembly. Newly formed glutamatergic synapses are initially silent and require activity-dependent plasticity to become fully functional connections.
Dimitra, Vardalaki +2 more
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Postsynaptic silent synapses: evidence and mechanisms
Neuropharmacology, 2003In this review I discuss the evidence that some glutamatergic synapses exist that lack surface-expressed postsynaptic AMPA receptors (AMPARs) but contain NMDA receptors opposed to a functional release site. I have summarised the electrophysiological, anatomical and cell biological evidence for such postsynaptically silent synapses, and data that ...
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Creation of AMPA-silent synapses in the neonatal hippocampus
Nature Neuroscience, 2004In the developing brain, many glutamate synapses have been found to transmit only NMDA receptor-mediated signaling, that is, they are AMPA-silent. This result has been taken to suggest that glutamate synapses are initially AMPA-silent when they are formed, and that AMPA signaling is acquired through activity-dependent synaptic plasticity.
Eric Hanse +3 more
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Evidence for presynaptically silent synapses in the immature hippocampus
Biochemical and Biophysical Research Communications, 2017Silent synapses show NMDA receptor (NMDAR)-mediated synaptic responses, but not AMPAR-mediated synaptic responses. A prevailing hypothesis states that silent synapses contain NMDARs, but not AMPARs. However, alternative presynaptic hypotheses, according to which AMPARs are present at silent synapses, have been proposed; silent synapses show slow ...
Jae Young Yoon, Sukwoo Choi
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