Results 11 to 20 of about 24,094 (177)
Presynaptically silent synapses are modulated by the density of surrounding astrocytes [PDF]
Journal of Pharmacological Sciences, 2020 Astrocytes, comprising the primary glial-cell type, are involved in the formation and maturation of synapses, and thus contribute to sustainable synaptic transmission between neurons.
Kohei Oyabu +7 more
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Endocannabinoids: The silent partner of glucocorticoids in the synapse [PDF]
Proceedings of the National Academy of Sciences, 2009 Although it has long been recognized that steroid hormones primarily exert their effects on neuronal function through their ability to modulate gene transcription in the nucleus (1), an array of physiological and behavioral effects of glucocorticoids have been documented to occur in a fashion that cannot be explained by genomic regulation (2).
Matthew N. Hill, Bruce S. McEwen
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eLife, 2017 In adult neurogenesis young neurons connect to the existing network via formation of thousands of new synapses. At early developmental stages, glutamatergic synapses are sparse, immature and functionally 'silent', expressing mainly NMDA receptors.
Liyi Li +5 more
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Competition at silent synapses in reinnervated skeletal muscle [PDF]
Nature Neuroscience, 2000 Synaptic connections are made and broken in an activity-dependent manner in diverse regions of the nervous system. However, whether activity is strictly necessary for synapse elimination has not been resolved directly. Here we report that synaptic terminals occupying motor endplates made electrically silent by tetrodotoxin and alpha-bungarotoxin block ...
Ellen M. Costanzo +2 more
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GluN2B-mediated regulation of silent synapses for receptor specification and addiction memory. [PDF]
Exp Mol MedKim HJ +11 more
europepmc +4 more sources
Silent synapses and the emergence of a postsynaptic mechanism for LTP [PDF]
Nature Reviews Neuroscience, 2008 Silent synapses abound in the young brain, representing an early step in the pathway of experience-dependent synaptic development. Discovered amidst the debate over whether long-term potentiation reflects a presynaptic or a postsynaptic modification, silent synapses--which in the hippocampal CA1 subfield are characterized by the presence of NMDA ...
Geoffrey A. Kerchner, Roger A. Nicoll
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Increased excitatory synapse size in hippocampal place cells compared to silent cells. [PDF]
Proc Natl Acad Sci U S AHeredi J +7 more
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A silent synapse-based mechanism for cocaine-induced locomotor sensitization. [PDF]
J Neurosci, 2011 Brown TE +16 more
europepmc +3 more sources
Presynaptically Silent Synapses [PDF]
The Neuroscientist, 2011 Synapses represent the main junctures of communication between neurons in the nervous system. In many neurotransmitter systems, a fraction of presynaptic terminals fails to release vesicles in response to action potential stimulation and strong calcium influx.
Devon C. Crawford, Steven Mennerick
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Silent synapse activation in epilepsy [PDF]
Neuropsychiatry, 2016 Epilepsy is a life-threatening chronic disease in a state of neuronal over electric activity. The precise nature of the seizure recurrence has not been clearly. Synapses can be divided into silent and functional synapse.Silent synapses, defined as structural specializations for neurotransmission that do not produce a physiological response in the ...
Zhi-Qin Xi +3 more
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