Chronic Inactivation of a Neural Circuit Enhances LTP by Inducing Silent Synapse Formation [PDF]
J Neurosci, 2013 Chronic inactivation of a neural network is known to induce homeostatic upregulation of synaptic strength, a form of synaptic plasticity that differs from Hebbian-type synaptic plasticity in that it is not input-specific, but involves all synapses of an ...
Kristin L. Arendt, F Sarti, Lu Chen
semanticscholar +3 more sources
A Silent Synapse-Based Mechanism for Cocaine-Induced Locomotor Sensitization [PDF]
J Neurosci, 2011 Locomotor sensitization is a common and robust behavioral alteration in rodents whereby following exposure to abused drugs such as cocaine, the animal becomes significantly more hyperactive in response to an acute drug challenge.
Travis E. Brown +16 more
semanticscholar +3 more sources
Dietary regulation of silent synapses in the dorsolateral striatum [PDF]
NeuroscienceABSTRACTObesity and drugs of abuse share overlapping neural circuits and behaviors. Silent synapses are transient synapses that are important for remodeling brain circuits. They are prevalent during early development but largely disappear by adulthood.
Allison M Meyers +5 more
europepmc +5 more sources
Bidirectional Modulation of Incubation of Cocaine Craving by Silent Synapse-Based Remodeling of Prefrontal Cortex to Accumbens Projections [PDF]
Neuron, 2014 Yao-Ying Ma +13 more
semanticscholar +4 more sources
Silent Synapses during Development of Thalamocortical Inputs [PDF]
Neuron, 1997 During development, activity-dependent mechanisms are thought to contribute to the refinement of topographical projections from the thalamus to the cortex. Because activity-dependent increases in synaptic strength may contribute to the stabilization of synaptic connections, we have explored the mechanisms of long-term potentiation (LTP) at ...
John Isaac +3 more
openalex +3 more sources
Wnt-5a induces the conversion of silent to functional synapses in the hippocampus
Frontiers in Molecular Neuroscience, 2022 Synapse unsilencing is an essential mechanism for experience-dependent plasticity. Here, we showed that the application of the ligand Wnt-5a converts glutamatergic silent synapses into functional ones by increasing both α-amino-3-hydroxy-5-methyl-4 ...
Carla Álvarez-Ferradas +9 more
doaj +2 more sources
IBRO Neuroscience Reports, 2023 Spinal cord injury (SCI) leads to devastating physical consequences, such as severe sensorimotor dysfunction even lifetime disability, by damaging the corticospinal system.
Mingcong Chen +7 more
doaj +2 more sources
(−)-Gallocatechin gallate from green tea rescues cognitive impairment through restoring hippocampal silent synapses in post-menopausal depression [PDF]
Scientific Reports, 2021 Post-menopausal depression (PMD) is a common psychological disorder accompanied by a cognitive deficit, which is caused by a series of uncontrolled emotional disruptions by strong environmental stressors during menopause.
Sukjin Ko +7 more
doaj +2 more sources
Synaptically silent sensory hair cells in zebrafish are recruited after damage
Nature Communications, 2018 Hair cells of the inner ear are mechanosensors that detect sound, and synapse onto afferent neurons. Here, the authors used calcium imaging to find that not all hair cells are synaptically engaged, but after damage these silent cells are synaptically ...
Qiuxiang Zhang +7 more
doaj +2 more sources
An opposing function of paralogs in balancing developmental synapse maturation.
PLoS Biology, 2018 The disc-large (DLG)-membrane-associated guanylate kinase (MAGUK) family of proteins forms a central signaling hub of the glutamate receptor complex. Among this family, some proteins regulate developmental maturation of glutamatergic synapses, a process ...
Plinio D Favaro +10 more
doaj +2 more sources