Results 21 to 30 of about 24,094 (177)
Silent Synapse-Based Circuitry Remodeling in Drug Addiction. [PDF]
Int J Neuropsychopharmacol, 2016 Exposure to cocaine, and likely other drugs of abuse, generates α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor-silent glutamatergic synapses in the nucleus accumbens. These immature synaptic contacts evolve after drug withdrawal to redefine the neurocircuital properties. These results raise at least three critical questions: (1) what are
Dong Y.
europepmc +5 more sources
Dietary regulation of silent synapses in the dorsolateral striatum
NeuroscienceABSTRACTObesity and drugs of abuse share overlapping neural circuits and behaviors. Silent synapses are transient synapses that are important for remodeling brain circuits. They are prevalent during early development but largely disappear by adulthood.
Allison M Meyers +5 more
+6 more sources
A Synthetic Likelihood Solution to the Silent Synapse Estimation Problem [PDF]
Cell Reports, 2020 SummaryFunctional features of populations of synapses are typically inferred from random electrophysiological sampling of small subsets of synapses. Are these samples unbiased? Here, we developed a biophysically constrained statistical framework for addressing this question and applied it to assess the performance of a widely used method based on a ...
Michael Lynn +4 more
openalex +6 more sources
Silent Synapses during Development of Thalamocortical Inputs [PDF]
Neuron, 1997 During development, activity-dependent mechanisms are thought to contribute to the refinement of topographical projections from the thalamus to the cortex. Because activity-dependent increases in synaptic strength may contribute to the stabilization of synaptic connections, we have explored the mechanisms of long-term potentiation (LTP) at ...
John Isaac +3 more
openalex +5 more sources
Generation of Silent Synapses by Acute In Vivo Expression of CaMKIV and CREB [PDF]
Neuron, 2005 The transcription factor CREB is critical for several forms of experience-dependent plasticity in a range of species and is commonly activated in neurons by calcium/calmodulin-dependent protein kinase IV (CaMKIV). Surprisingly, little is known about the neural circuit adaptations caused by activation of CaMKIV and CREB. Here, we use viral-mediated gene
Hélène Marie +4 more
openalex +4 more sources
Astrocytic density tunes presynaptically silent synapses
Proceedings for Annual Meeting of The Japanese Pharmacological Society, 2021 Shutaro Katsurabayashi +5 more
openalex +3 more sources
Sound of silent synapses from the addicted hippocampus [PDF]
Neuropsychopharmacology, 2018 Eisuke Koya, Yan Dong
openalex +4 more sources
Cell Reports, 2017 Experience-dependent synapse refinement is essential for functional optimization of neural circuits. However, how sensory experience sculpts excitatory synaptic transmission is poorly understood.
Kyung-Seok Han +2 more
doaj +1 more source
Wnt-5a induces the conversion of silent to functional synapses in the hippocampus
Frontiers in Molecular Neuroscience, 2022 Synapse unsilencing is an essential mechanism for experience-dependent plasticity. Here, we showed that the application of the ligand Wnt-5a converts glutamatergic silent synapses into functional ones by increasing both α-amino-3-hydroxy-5-methyl-4 ...
Carla Álvarez-Ferradas +9 more
doaj +1 more source