Results 21 to 30 of about 281,837 (328)
Ribbon synapse plasticity in the cochleae of Guinea pigs after noise-induced silent damage.
PLoS ONE, 2013 Noise exposure at low levels or low doses can damage hair cell afferent ribbon synapses without causing permanent threshold shifts. In contrast to reports in the mouse cochleae, initial damage to ribbon synapses in the cochleae of guinea pigs is largely ...
Lijuan Shi +6 more
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Neuronal pentraxins mediate silent synapse conversion in the developing visual system [PDF]
J Neurosci, 2008 Neuronal pentraxins (NPs) are hypothesized to play important roles in the recruitment of AMPA receptors (AMPARs) to immature synapses, yet a physiological role for NPs at nascent synapses in vivo has remained elusive.
Selina M. Koch, E. Ullian
semanticscholar +2 more sources
Bioinspired activation of silent synapses in layered materials for extensible neuromorphic computing
Journal of Materiomics, 2023 Activation of silent synapses is of great significance for the extension of neural plasticity related to learning and memory. Inspired by the activation of silent synapses via receptor insertion in neural synapses, we propose an efficient method for ...
Yan Kang +7 more
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Silent Synapses Sit and Wait for a Better Day [PDF]
Neuron, 2009 Synaptic activity is thought to be critical for synaptic stabilization. In this issue of Neuron, Krishnaswamy and Cooper show that nicotinic synapses on autonomic neurons remain intact without synaptic activity. Postsynaptic responses are required, however, for presynaptic terminals to acquire the high-affinity choline transporter necessary for high ...
Darwin K. Berg
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Sleep need driven oscillation of glutamate synaptic phenotype [PDF]
eLifeSleep loss increases AMPA-synaptic strength and number in the neocortex. However, this is only part of the synaptic sleep loss response. We report an increased AMPA/NMDA EPSC ratio in frontal-cortical pyramidal neurons of layers 2–3.
Kaspar E Vogt +5 more
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A Synthetic Likelihood Solution to the Silent Synapse Estimation Problem [PDF]
Cell Reports, 2020 SummaryFunctional features of populations of synapses are typically inferred from random electrophysiological sampling of small subsets of synapses. Are these samples unbiased? Here, we developed a biophysically constrained statistical framework for addressing this question and applied it to assess the performance of a widely used method based on a ...
Michael Lynn +4 more
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Endocannabinoids: The silent partner of glucocorticoids in the synapse [PDF]
Proceedings of the National Academy of Sciences, 2009 Although it has long been recognized that steroid hormones primarily exert their effects on neuronal function through their ability to modulate gene transcription in the nucleus (1), an array of physiological and behavioral effects of glucocorticoids have been documented to occur in a fashion that cannot be explained by genomic regulation (2).
M. Hill, B. McEwen
semanticscholar +3 more sources
Presynaptically Silent Synapses Studied with Light Microscopy [PDF]
Journal of Visualized Experiments, 2010 Synaptic plasticity likely underlies the nervous system's ability to learn and remember and may also represent an adaptability that prevents otherwise damaging insults from becoming neurotoxic. We have been studying a form of presynaptic plasticity that is interesting in part because it is expressed as a digital switching on and off of a presynaptic ...
Krista L. Moulder +4 more
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The EMBO JournalThe precise organization of pre- and postsynaptic terminals is crucial for normal synaptic function in the brain. In addition to its canonical role as a neurotrophin-3 receptor tyrosine kinase, postsynaptic TrkC promotes excitatory synapse organization ...
Husam Khaled +14 more
doaj +2 more sources
Ulnar Neuropathy with Silent Synapses [PDF]
Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques, 2022 Lawrence R. Robinson, Paul Binhammer
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