Results 31 to 40 of about 24,094 (177)
Modeling Maintenance of Long-Term Potentiation in Clustered Synapses, Long-Term Memory Without Bistability [PDF]
, 2015 Memories are stored, at least partly, as patterns of strong synapses. Given molecular turnover, how can synapses maintain strong for the years that memories can persist?
Smolen, Paul
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In Vivo Cocaine Experience Generates Silent Synapses [PDF]
Neuron, 2009 Studies over the past decade have enunciated silent synapses as prominent cellular substrates for synaptic plasticity in the developing brain. However, little is known about whether silent synapses can be generated postdevelopmentally. Here, we demonstrate that highly salient in vivo experience, such as exposure to cocaine, generates silent synapses in
Huang, Yanhua H +12 more
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Postsynaptically Silent Synapses in Single Neuron Cultures [PDF]
Neuron, 1998 We have used the synapses that isolated hippocampal cells in culture form onto themselves (autapses) to determine if some synapses lack functional AMPA receptors (AMPARs). A comparison of the synaptic variability of the AMPAR- and NMDAR-mediated evoked responses, as well as of miniature synaptic responses, indicates that a population of events exists ...
Robert C. Malenka +4 more
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Optimal learning rules for discrete synapses [PDF]
, 2008 There is evidence that biological synapses have a limited number of discrete weight states. Memory storage with such synapses behaves quite differently from synapses with unbounded, continuous weights, as old memories are automatically overwritten by new
Barrett, Adam B, van Rossum, M C W
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Presynaptically Silent Synapses Studied with Light Microscopy [PDF]
Journal of Visualized Experiments, 2010 Synaptic plasticity likely underlies the nervous system's ability to learn and remember and may also represent an adaptability that prevents otherwise damaging insults from becoming neurotoxic. We have been studying a form of presynaptic plasticity that is interesting in part because it is expressed as a digital switching on and off of a presynaptic ...
Krista L. Moulder +4 more
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Serotonin drives a novel GABAergic synaptic current recorded in rat cerebellar purkinje cells: a lugaro cell to Purkinje cell synapse [PDF]
, 2003 We recorded a novel fast GABAergic synaptic current in cerebellar Purkinje cells in rat brain slices using patch-clamp techniques. Because of a relatively low sensitivity to bicuculline, these currents can be recorded under conditions in which basket ...
Dean, I., Edwards, F.A., Robertson, S.J.
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Silent Synapses in Cocaine-Associated Memory and Beyond
The Journal of Neuroscience, 2021 Glutamatergic synapses are key cellular sites where cocaine experience creates memory traces that subsequently promote cocaine craving and seeking. In addition to making across-the-board synaptic adaptations, cocaine experience also generates a discrete population of new synapses that selectively encode cocaine memories.
William J. Wright, Yan Dong
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Why Neurons Have Thousands of Synapses, A Theory of Sequence Memory in Neocortex [PDF]
, 2015 Neocortical neurons have thousands of excitatory synapses. It is a mystery how neurons integrate the input from so many synapses and what kind of large-scale network behavior this enables.
Ahmad, Subutai, Hawkins, Jeff
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Neuroscience ResearchAbstractDespite the crucial role of synaptic connections and neural activity in the development and organization of cortical circuits, the mechanisms underlying the formation of functional synaptic connections in the developing human cerebral cortex remain unclear.
Masatoshi Nishimura +7 more
+6 more sources
eLife, 2015 Kainate receptors (KARs) are a subfamily of glutamate receptors mediating excitatory synaptic transmission and Neto proteins are recently identified auxiliary subunits for KARs. However, the roles of Neto proteins in the synaptic trafficking of KAR GluK1
Nengyin Sheng +4 more
doaj +1 more source